| The hypoxia-associated factor switches cells from HIF-1α-to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion MY Koh, R Lemos Jr, X Liu, G Powis Cancer research 71 (11), 4015-4027, 2011 | 396 | 2011 |
| Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents M Mao, F Tian, JM Mariadason, CC Tsao, R Lemos Jr, F Dayyani, ... Clinical cancer research 19 (3), 657-667, 2013 | 332 | 2013 |
| Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance NT Ihle, R Lemos Jr, P Wipf, A Yacoub, C Mitchell, D Siwak, GB Mills, ... Cancer research 69 (1), 143-150, 2009 | 317 | 2009 |
| The promise of patient-derived xenografts: the best laid plans of mice and men S Kopetz, R Lemos, G Powis Clinical cancer research 18 (19), 5160-5162, 2012 | 201 | 2012 |
| In vivo therapeutic silencing of hypoxia-inducible factor 1 alpha (HIF-1α) using single-walled carbon nanotubes noncovalently coated with siRNA G Bartholomeusz, P Cherukuri, J Kingston, L Cognet, R Lemos, TK Leeuw, ... Nano research 2, 279-291, 2009 | 125 | 2009 |
| HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer HR Chang, S Nam, MC Kook, KT Kim, X Liu, H Yao, HR Jung, R Lemos, ... Gut 65 (1), 19-32, 2016 | 124 | 2016 |
| The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects DL Schwartz, G Powis, A Thitai-Kumar, Y He, J Bankson, R Williams, ... Molecular cancer therapeutics 8 (4), 947-958, 2009 | 113 | 2009 |
| Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer DL Schwartz, JA Bankson, R Lemos Jr, SY Lai, AK Thittai, Y He, ... Molecular cancer therapeutics 9 (7), 2057-2067, 2010 | 103 | 2010 |
| Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor EJ Meuillet, S Zuohe, R Lemos, N Ihle, J Kingston, R Watkins, SA Moses, ... Molecular cancer therapeutics 9 (3), 706-717, 2010 | 84 | 2010 |
| Definition of a novel feed-forward mechanism for glycolysis-HIF1α signaling in hypoxic tumors highlights aldolase A as a therapeutic target G Grandjean, PR de Jong, BP James, MY Koh, R Lemos, J Kingston, ... Cancer research 76 (14), 4259-4269, 2016 | 68 | 2016 |
| In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT SA Moses, MA Ali, S Zuohe, L Du-Cuny, LL Zhou, R Lemos, N Ihle, ... Cancer research 69 (12), 5073-5081, 2009 | 68 | 2009 |
| Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma MY Koh, V Nguyen, R Lemos Jr, BG Darnay, G Kiriakova, M Abdelmelek, ... Cancer research 75 (2), 316-329, 2015 | 51 | 2015 |
| HIF-1–Dependent Stromal Adaptation to Ischemia Mediates In Vivo Tumor Radiation Resistance DL Schwartz, J Bankson, L Bidaut, Y He, R Williams, R Lemos, AK Thitai, ... Molecular Cancer Research 9 (3), 259-270, 2011 | 41 | 2011 |
| A new HIF‐1α/RANTES‐driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice MY Koh, M Gagea, T Sargis, R Lemos Jr, G Grandjean, A Charbono, ... Hepatology 63 (5), 1576-1591, 2016 | 39 | 2016 |
| Peroxisome proliferator-activated receptor γ agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without … NT Ihle, R Lemos, D Schwartz, J Oh, RJ Halter, P Wipf, L Kirkpatrick, ... Molecular cancer therapeutics 8 (1), 94-100, 2009 | 32 | 2009 |
| Absence of HIF1A leads to glycogen accumulation and an inflammatory response that enables pancreatic tumor growth M Maruggi, FI Layng, R Lemos Jr, G Garcia, BP James, M Sevilla, ... Cancer research 79 (22), 5839-5848, 2019 | 25 | 2019 |
| An inhibitor of the pleckstrin homology domain of CNK1 selectively blocks the growth of mutant KRAS cells and tumors M Indarte, R Puentes, M Maruggi, NT Ihle, G Grandjean, M Scott, Z Ahmed, ... Cancer research 79 (12), 3100-3111, 2019 | 21 | 2019 |
| Detection of bacterial DNA in acute and chronic cholecystitis R Lemos, PHC França, LE Ferreira, AR Goncalves, ACL Campos, ... Journal of British Surgery 97 (4), 532-536, 2010 | 15 | 2010 |
| Metformin increases AMPKα activity by inhibition of AMPKα and cell cycle proliferation in Asian gastric cancer. HR Jung, HR Chang, HH Seo, R Lemos, HS Park, H Liang, G Powis, ... Cancer Research 73 (8_Supplement), 5534-5534, 2013 | 2 | 2013 |
| Targeting lysophospholipid metabolism inhibits pancreatic cancer cell proliferation under nutrient-limiting conditions PR Jong, M Maruggi, AD Campos, MA Brand, R Lemos, DA Scott, ... Cancer Research 78 (13_Supplement), 2916-2916, 2018 | 1 | 2018 |
