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Stephen W. Fesik
Stephen W. Fesik
Professor of Biochemistry, Pharmacology, and Chemistry; Orrin H. Ingram II Chair in Cancer Research, Vanderbilt University
Verified email at vanderbilt.edu - Homepage
Title
Cited by
Cited by
Year
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf, SW Elmore, AR Shoemaker, RC Armstrong, DJ Augeri, ...
Nature 435 (7042), 677-681, 2005
40512005
Discovering high-affinity ligands for proteins: SAR by NMR
SB Shuker, PJ Hajduk, RP Meadows, SW Fesik
Science 274 (5292), 1531-1534, 1996
27501996
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
C Tse, AR Shoemaker, J Adickes, MG Anderson, J Chen, S Jin, ...
Cancer research 68 (9), 3421-3428, 2008
21832008
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis
M Sattler, H Liang, D Nettesheim, RP Meadows, JE Harlan, M Eberstadt, ...
Science 275 (5302), 983-986, 1997
20601997
X-ray and NMR structure of human Bcl-x L, an inhibitor of programmed cell death
SW Muchmore, M Sattler, H Liang, RP Meadows, JE Harlan, HS Yoon, ...
Nature 381 (6580), 335-341, 1996
20451996
Promoting apoptosis as a strategy for cancer drug discovery
SW Fesik
Nature Reviews Cancer 5 (11), 876-885, 2005
13872005
Bcl-x L forms an ion channel in synthetic lipid membranes
AJ Minn, P Vélez, SL Schendel, H Liang, SW Muchmore, SW Fesik, M Fill, ...
Nature 385 (6614), 353-357, 1997
11801997
Structural basis for the inhibition of caspase-3 by XIAP
SJ Riedl, M Renatus, R Schwarzenbacher, Q Zhou, C Sun, SW Fesik, ...
Cell 104 (5), 791-800, 2001
10932001
Pleckstrin homology domains bind to phosphatidylinositol-4, 5-bisphosphate
JE Harlan, PJ Hajduk, HS Yoon, SW Fesik
Nature 371 (6493), 168-170, 1994
10451994
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
Z Liu, C Sun, ET Olejniczak, RP Meadows, SF Betz, T Oost, J Herrmann, ...
Nature 408 (6815), 1004-1008, 2000
8602000
Heteronuclear three-dimensional NMR spectroscopy. A strategy for the simplification of homonuclear two-dimensional NMR spectra
SW Fesik, ERP Zuiderweg
Journal of Magnetic Resonance (1969) 78 (3), 588-593, 1988
5791988
Discovery of small molecules that bind to K‐Ras and inhibit Sos‐mediated activation
Q Sun, JP Burke, J Phan, MC Burns, ET Olejniczak, AG Waterson, T Lee, ...
Angewandte Chemie International Edition 51 (25), 6140-6143, 2012
5482012
NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP
C Sun, M Cai, AH Gunasekera, RP Meadows, H Wang, J Chen, H Zhang, ...
Nature 401 (6755), 818-822, 1999
5321999
NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
B Huang, M Eberstadt, ET Olejniczak, RP Meadows, SW Fesik
Nature 384 (6610), 638-641, 1996
5251996
Insights into programmed cell death through structural biology
SW Fesik
Cell 103 (2), 273-282, 2000
4882000
Structure and ligand recognition of the phosphotyrosine binding domain of Shc
MM Zhou, KS Ravichandran, ET Olejniczak, AM Petros, RP Meadows, ...
Nature 378 (6557), 584-592, 1995
4681995
Discovery of potent nonpeptide inhibitors of stromelysin using SAR by NMR
PJ Hajduk, G Sheppard, DG Nettesheim, ET Olejniczak, SB Shuker, ...
Journal of the American Chemical Society 119 (25), 5818-5827, 1997
4631997
Drugging an undruggable pocket on KRAS
D Kessler, M Gmachl, A Mantoulidis, LJ Martin, A Zoephel, M Mayer, ...
Proceedings of the National Academy of Sciences 116 (32), 15823-15829, 2019
3522019
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design
A Friberg, D Vigil, B Zhao, RN Daniels, JP Burke, PM Garcia-Barrantes, ...
Journal of medicinal chemistry 56 (1), 15-30, 2013
3162013
NMR structure and mutagenesis of the FADD (Mort1) death-effector domain
M Eberstadt, B Huang, Z Chen, RP Meadows, SC Ng, L Zheng, ...
Nature 392 (6679), 941-945, 1998
3081998
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