Systemic delivery of factor IX messenger RNA for protein replacement therapy S Ramaswamy, N Tonnu, K Tachikawa, P Limphong, JB Vega, ... Proceedings of the National Academy of Sciences 114 (10), E1941-E1950, 2017 | 274 | 2017 |
Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel C Liu, G Zhao, J Liu, N Ma, P Chivukula, L Perelman, K Okada, Z Chen, ... Journal of controlled release 140 (3), 277-283, 2009 | 146 | 2009 |
Effect of PEGylation on biodistribution and gene silencing of siRNA/lipid nanoparticle complexes Y Bao, Y Jin, P Chivukula, J Zhang, Y Liu, J Liu, JP Clamme, RI Mahato, ... Pharmaceutical research 30, 342-351, 2013 | 109 | 2013 |
Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels P Chivukula, K Dušek, D Wang, M Dušková-Smrčková, P Kopečková, ... Biomaterials 27 (7), 1140-1151, 2006 | 76 | 2006 |
Lipid nanoparticle-mediated siRNA transfer against PCTAIRE1/PCTK1/Cdk16 inhibits in vivo cancer growth T Yanagi, K Tachikawa, R Wilkie-Grantham, A Hishiki, K Nagai, ... Molecular Therapy-Nucleic Acids 5, 2016 | 54 | 2016 |
Effect of molecular weight of PGG–paclitaxel conjugates on in vitro and in vivo efficacy D Yang, X Liu, X Jiang, Y Liu, W Ying, H Wang, H Bai, WD Taylor, Y Wang, ... Journal of controlled release 161 (1), 124-131, 2012 | 47 | 2012 |
Immune modulatory nanoparticle therapeutics for intracerebral glioma NK Yaghi, J Wei, Y Hashimoto, LY Kong, K Gabrusiewicz, EK Nduom, ... Neuro-oncology 19 (3), 372-382, 2017 | 44 | 2017 |
Allele selective gene editing and uses thereof P Chivukula, R Wilkie-Grantham, K Tachikawa US Patent 10,369,232, 2019 | 42 | 2019 |
Long non-coding RNA BGas regulates the cystic fibrosis transmembrane conductance regulator SM Saayman, A Ackley, J Burdach, M Clemson, DC Gruenert, ... Molecular Therapy 24 (8), 1351-1357, 2016 | 37 | 2016 |
Asymmetric ionizable cationic lipid for RNA delivery JE Payne, P Chivukula, D Webb US Patent 9,365,610, 2016 | 34* | 2016 |
Ionizable cationic lipid for RNA delivery JE Payne, P Chivukula US Patent 9,593,077, 2017 | 32 | 2017 |
Development of an mRNA replacement therapy for phenylketonuria CG Perez-Garcia, R Diaz-Trelles, JB Vega, Y Bao, M Sablad, P Limphong, ... Molecular Therapy-Nucleic Acids 28, 87-98, 2022 | 30 | 2022 |
CD8+ T cells mediate protection against Zika virus induced by an NS3-based vaccine A Elong Ngono, T Syed, AV Nguyen, JA Regla-Nava, M Susantono, ... Science Advances 6 (45), eabb2154, 2020 | 26 | 2020 |
Ionizable cationic lipid for RNA delivery JE Payne, P Chivukula, P Karmali, SP Tanis US Patent 10,526,284, 2020 | 22 | 2020 |
Anti-HFRS human IgG produced in transchromosomic bovines has potent hantavirus neutralizing activity and is protective in animal models CC Perley, RL Brocato, H Wu, C Bausch, E Sullivan, JW Hooper Frontiers in Microbiology 11, 529650, 2020 | 21 | 2020 |
Property-driven design and development of lipids for efficient delivery of siRNA K Rajappan, SP Tanis, R Mukthavaram, S Roberts, M Nguyen, ... Journal of Medicinal Chemistry 63 (21), 12992-13012, 2020 | 19 | 2020 |
Coronavirus vaccine compositions and methods SM Sullivan, D Matsuda, K Tachikawa, P Chivukula, PP Karmali, JH Davis, ... US Patent 11,744,887, 2023 | 18 | 2023 |
Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS T Hirunagi, K Sahashi, K Tachikawa, AI Leu, M Nguyen, R Mukthavaram, ... Molecular Therapy-Nucleic Acids 24, 1-10, 2021 | 18 | 2021 |
Trinucleotide MRNA cap analogs P Chivukula, SP Tanis, JE Payne US Patent 10,487,105, 2019 | 15 | 2019 |
Compositions and methods for inducing immune responses SM Sullivan, D Matsuda, K Tachikawa, P Chivukula, PP Karmali, JH Davis, ... US Patent 11,759,515, 2023 | 14 | 2023 |