| Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators Y Wang, CE Kaiser, B Frett, H Li Journal of medicinal chemistry 56 (13), 5219-5230, 2013 | 156 | 2013 |
| Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2 J Wang, P Cheng, MS Pavlyukov, H Yu, Z Zhang, SH Kim, M Minata, ... The Journal of clinical investigation 127 (8), 3075-3089, 2017 | 82 | 2017 |
| Selective reduction of halogenated nitroarenes with hydrazine hydrate in the presence of Pd/C F Li, B Frett, H Li Synlett 25 (10), 1403-1408, 2014 | 70 | 2014 |
| Efficient Access to 2,3-Diarylimidazo[1,2-a]pyridines via a One-Pot, Ligand-Free, Palladium-Catalyzed Three-Component Reaction under Microwave Irradiation Y Wang, B Frett, H Li Organic letters 16 (11), 3016-3019, 2014 | 65 | 2014 |
| Synthesis of tetrazolo-fused benzodiazepines and benzodiazepinones by a two-step protocol using an Ugi-azide reaction for initial diversity generation S Gunawan, M Ayaz, F De Moliner, B Frett, C Kaiser, N Patrick, Z Xu, ... Tetrahedron 68 (27-28), 5606-5611, 2012 | 61 | 2012 |
| Insights into current tropomyosin receptor kinase (TRK) inhibitors: development and clinical application W Yan, NR Lakkaniga, F Carlomagno, M Santoro, NQ McDonald, F Lv, ... Journal of medicinal chemistry 62 (4), 1731-1760, 2018 | 60 | 2018 |
| Structure-based design and synthesis of imidazo [1, 2-a] pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities JB Xi, YF Fang, B Frett, ML Zhu, T Zhu, YN Kong, FJ Guan, Y Zhao, ... European Journal of Medicinal Chemistry 126, 1083-1106, 2017 | 48 | 2017 |
| Fragment‐based discovery of a dual pan‐RET/VEGFR2 kinase inhibitor optimized for single‐agent polypharmacology B Frett, F Carlomagno, ML Moccia, A Brescia, G Federico, V De Falco, ... Angewandte Chemie 127 (30), 8841-8845, 2015 | 42 | 2015 |
| Metal-free, efficient hydrazination of imidazo [1, 2-a] pyridine with diethyl azodicarboxylate in neutral media Y Wang, B Frett, N McConnell, H Li Organic & biomolecular chemistry 13 (10), 2958-2964, 2015 | 41 | 2015 |
| Catalyst free, C-3 functionalization of imidazo [1, 2-a] pyridines to rapidly access new chemical space for drug discovery efforts N Gunaganti, A Kharbanda, NR Lakkaniga, L Zhang, R Cooper, H Li, ... Chemical communications 54 (92), 12954-12957, 2018 | 34 | 2018 |
| Recent advances in the development of polycyclic skeletons via Ugi reaction cascades J Lei, JP Meng, DY Tang, B Frett, ZZ Chen, ZG Xu Molecular Diversity 22, 503-516, 2018 | 33 | 2018 |
| A p-toluenesulfinic acid-catalyzed three-component Ugi-type reaction and its application for the synthesis of α-amino amides and amidines B Saha, B Frett, Y Wang, H Li Tetrahedron Letters 54 (19), 2340-2343, 2013 | 33 | 2013 |
| Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors B Frett, N McConnell, CC Smith, Y Wang, NP Shah, H Li European journal of medicinal chemistry 94, 123-131, 2015 | 30 | 2015 |
| Hypervalent iodine mediated efficient solvent-free regioselective halogenation and thiocyanation of fused N-heterocycles DR Indukuri, GR Potuganti, M Alla Synlett 30 (13), 1573-1579, 2019 | 29 | 2019 |
| The exploration of chirality for improved druggability within the human kinome D Saha, A Kharbanda, W Yan, NR Lakkaniga, B Frett, HY Li Journal of medicinal chemistry 63 (2), 441-469, 2019 | 28 | 2019 |
| Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells LJ He, DL Yang, SQ Li, YJ Zhang, Y Tang, J Lei, B Frett, H Lin, H Li, ... Bioorganic & medicinal chemistry 26 (14), 3899-3908, 2018 | 28 | 2018 |
| Therapeutic Melting Pot of Never in Mitosis Gene A Related Kinase 2 (Nek2): A Perspective on Nek2 as an Oncology Target and Recent Advancements in Nek2 Small Molecule … B Frett, RV Brown, M Ma, W Hu, H Han, H Li Journal of medicinal chemistry 57 (14), 5835-5844, 2014 | 26 | 2014 |
| Discovery of SP-96, the first non-ATP-competitive Aurora Kinase B inhibitor, for reduced myelosuppression NR Lakkaniga, L Zhang, B Belachew, N Gunaganti, B Frett, H Li European Journal of Medicinal Chemistry 203, 112589, 2020 | 25 | 2020 |
| Identification of two novel RET kinase inhibitors through MCR-based drug discovery: design, synthesis and evaluation B Frett, M Moccia, F Carlomagno, M Santoro, H Li European journal of medicinal chemistry 86, 714-723, 2014 | 23 | 2014 |
| An expeditious approach to access 2-arylimidazo [1, 2-a] pyridin-3-ol from 2-amino pyridine through a novel Petasis based cascade reaction Y Wang, B Saha, F Li, B Frett, H Li Tetrahedron Letters 55 (7), 1281-1284, 2014 | 23 | 2014 |
