Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex DR Calabrese, X Chen, EC Leon, SM Gaikwad, Z Phyo, WM Hewitt, ... Nature communications 9 (1), 4229, 2018 | 142 | 2018 |
IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells RK Singh, SM Gaikwad, A Jinager, S Chaudhury, A Maheshwari, P Ray Cancer letters, 2014 | 65 | 2014 |
Magnetic nanoparticle-mediated hyperthermia therapy induces tumour growth inhibition by apoptosis and Hsp90/AKT modulation NG Shetake, A Kumar, S Gaikwad, P Ray, S Desai, RS Ningthoujam, ... International Journal of Hyperthermia 31 (8), 909-919, 2015 | 47 | 2015 |
Differential activation of NF-κB signaling is associated with platinum and taxane resistance in MyD88 deficient epithelial ovarian cancer cells SM Gaikwad, B Thakur, A Sakpal, RK Singh, P Ray The international journal of biochemistry & cell biology 61, 90-102, 2015 | 33 | 2015 |
Cooperative targets of combined mTOR/HDAC inhibition promote MYC degradation JK Simmons, AM Michalowski, BJ Gamache, W DuBois, J Patel, K Zhang, ... Molecular cancer therapeutics 16 (9), 2008-2021, 2017 | 32 | 2017 |
Non-invasive imaging of PI3K/Akt/mTOR signalling in cancer SM Gaikwad, P Ray American journal of nuclear medicine and molecular imaging 2 (4), 418, 2012 | 31 | 2012 |
Characterization of clinically used oral antiseptics as quadruplex-binding ligands DR Calabrese, K Zlotkowski, S Alden, WM Hewitt, CM Connelly, ... Nucleic acids research 46 (6), 2722-2732, 2018 | 28 | 2018 |
A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis SV Vartak, M Hegde, D Iyer, S Gaikwad, V Gopalakrishnan, M Srivastava, ... Biochemical pharmacology 122, 10-22, 2016 | 26 | 2016 |
A small molecule stabilizer of the MYC G4-quadruplex induces endoplasmic reticulum stress, senescence and pyroptosis in multiple myeloma SM Gaikwad, Z Phyo, AQ Arteaga, S Gorjifard, DR Calabrese, D Connors, ... Cancers 12 (10), 2952, 2020 | 25 | 2020 |
Soft drug-resistant ovarian cancer cells migrate via two distinct mechanisms utilizing myosin II-based contractility A Kapoor, A Barai, B Thakur, A Das, SR Patwardhan, M Monteiro, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1865 (2), 392-405, 2018 | 24 | 2018 |
Non-invasive imaging of phosphoinositide-3-kinase-catalytic-subunit-alpha (PIK3CA) promoter modulation in small animal models SM Gaikwad, L Gunjal, AR Junutula, A Astanehe, SS Gambhir, P Ray PLoS One 8 (2), e55971, 2013 | 23 | 2013 |
Stem cells: The holy grail of regenerative medicine RK Singh, SM Gaikwad, S Chatterjee, P Ray Engineering in Translational Medicine, 19-69, 2014 | 17 | 2014 |
Hypomorphic mTOR downregulates CDK6 and delays thymic pre-T LBL tumorigenesis JM Gary, JK Simmons, J Xu, S Zhang, TJ Peat, N Watson, BJ Gamache, ... Molecular cancer therapeutics 19 (10), 2221-2232, 2020 | 8 | 2020 |
Mouse tumor susceptibility genes identify drug combinations for multiple myeloma S Zhang, W DuBois, K Zhang, JK Simmons, VK Hughitt, S Gorjifard, ... Journal of cancer metastasis and treatment 6, 2020 | 3 | 2020 |
Developing Clinically Relevant Acquired Chemoresistance Models in Epithelial Ovarian Cancer Cell Lines PS Shenoy, S Chakraborty, SM Gaikwad, A Sakpal, P Ray Bio-protocol 12 (3), e4310-e4310, 2022 | 2 | 2022 |
Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma TJ Peat, SM Gaikwad, W Dubois, N Gyabaah-Kessie, S Zhang, S Gorjifard, ... Cancer Letters 568, 216284, 2023 | 1 | 2023 |
Structural optimization and anticancer activity of Polo-Like Kinase 1 (Plk1) polo-box domain (PBD) Inhibitors and their prodrugs JE Park, H Lee, P Oliva, K Kirsch, B Kim, JI Ahn, CN Alverez, S Gaikwad, ... ACS Pharmacology & Translational Science 6 (3), 422-446, 2023 | 1 | 2023 |
Soft drug-resistant ovarian cancer cells invade via two distinct mechanisms utilizing myosin IIB A Kapoor, B Thakur, M Monteiro, A Das, S Desai, S Gaikwad, AB Bukhari, ... bioRxiv, 099655, 2017 | 1 | 2017 |
A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins X Lu, M Chandravanshi, VR Sabbasani, S Gaikwad, VK Hughitt, ... Nature Communications 15 (1), 2485, 2024 | | 2024 |
Metabolomic profiling identifies molecular modifiers contributing to proteasome inhibitor resistance in multiple myeloma SM Gaikwad, VK Hughitt, N Gyabaah-Kessie, M Matera-Vatnick, ... MOLECULAR CANCER THERAPEUTICS 22 (12), 2023 | | 2023 |