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SNEHAL M. GAIKWAD
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Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex
DR Calabrese, X Chen, EC Leon, SM Gaikwad, Z Phyo, WM Hewitt, ...
Nature communications 9 (1), 4229, 2018
1422018
IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells
RK Singh, SM Gaikwad, A Jinager, S Chaudhury, A Maheshwari, P Ray
Cancer letters, 2014
652014
Magnetic nanoparticle-mediated hyperthermia therapy induces tumour growth inhibition by apoptosis and Hsp90/AKT modulation
NG Shetake, A Kumar, S Gaikwad, P Ray, S Desai, RS Ningthoujam, ...
International Journal of Hyperthermia 31 (8), 909-919, 2015
472015
Differential activation of NF-κB signaling is associated with platinum and taxane resistance in MyD88 deficient epithelial ovarian cancer cells
SM Gaikwad, B Thakur, A Sakpal, RK Singh, P Ray
The international journal of biochemistry & cell biology 61, 90-102, 2015
332015
Cooperative targets of combined mTOR/HDAC inhibition promote MYC degradation
JK Simmons, AM Michalowski, BJ Gamache, W DuBois, J Patel, K Zhang, ...
Molecular cancer therapeutics 16 (9), 2008-2021, 2017
322017
Non-invasive imaging of PI3K/Akt/mTOR signalling in cancer
SM Gaikwad, P Ray
American journal of nuclear medicine and molecular imaging 2 (4), 418, 2012
312012
Characterization of clinically used oral antiseptics as quadruplex-binding ligands
DR Calabrese, K Zlotkowski, S Alden, WM Hewitt, CM Connelly, ...
Nucleic acids research 46 (6), 2722-2732, 2018
282018
A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis
SV Vartak, M Hegde, D Iyer, S Gaikwad, V Gopalakrishnan, M Srivastava, ...
Biochemical pharmacology 122, 10-22, 2016
262016
A small molecule stabilizer of the MYC G4-quadruplex induces endoplasmic reticulum stress, senescence and pyroptosis in multiple myeloma
SM Gaikwad, Z Phyo, AQ Arteaga, S Gorjifard, DR Calabrese, D Connors, ...
Cancers 12 (10), 2952, 2020
252020
Soft drug-resistant ovarian cancer cells migrate via two distinct mechanisms utilizing myosin II-based contractility
A Kapoor, A Barai, B Thakur, A Das, SR Patwardhan, M Monteiro, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1865 (2), 392-405, 2018
242018
Non-invasive imaging of phosphoinositide-3-kinase-catalytic-subunit-alpha (PIK3CA) promoter modulation in small animal models
SM Gaikwad, L Gunjal, AR Junutula, A Astanehe, SS Gambhir, P Ray
PLoS One 8 (2), e55971, 2013
232013
Stem cells: The holy grail of regenerative medicine
RK Singh, SM Gaikwad, S Chatterjee, P Ray
Engineering in Translational Medicine, 19-69, 2014
172014
Hypomorphic mTOR downregulates CDK6 and delays thymic pre-T LBL tumorigenesis
JM Gary, JK Simmons, J Xu, S Zhang, TJ Peat, N Watson, BJ Gamache, ...
Molecular cancer therapeutics 19 (10), 2221-2232, 2020
82020
Mouse tumor susceptibility genes identify drug combinations for multiple myeloma
S Zhang, W DuBois, K Zhang, JK Simmons, VK Hughitt, S Gorjifard, ...
Journal of cancer metastasis and treatment 6, 2020
32020
Developing Clinically Relevant Acquired Chemoresistance Models in Epithelial Ovarian Cancer Cell Lines
PS Shenoy, S Chakraborty, SM Gaikwad, A Sakpal, P Ray
Bio-protocol 12 (3), e4310-e4310, 2022
22022
Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma
TJ Peat, SM Gaikwad, W Dubois, N Gyabaah-Kessie, S Zhang, S Gorjifard, ...
Cancer Letters 568, 216284, 2023
12023
Structural optimization and anticancer activity of Polo-Like Kinase 1 (Plk1) polo-box domain (PBD) Inhibitors and their prodrugs
JE Park, H Lee, P Oliva, K Kirsch, B Kim, JI Ahn, CN Alverez, S Gaikwad, ...
ACS Pharmacology & Translational Science 6 (3), 422-446, 2023
12023
Soft drug-resistant ovarian cancer cells invade via two distinct mechanisms utilizing myosin IIB
A Kapoor, B Thakur, M Monteiro, A Das, S Desai, S Gaikwad, AB Bukhari, ...
bioRxiv, 099655, 2017
12017
A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins
X Lu, M Chandravanshi, VR Sabbasani, S Gaikwad, VK Hughitt, ...
Nature Communications 15 (1), 2485, 2024
2024
Metabolomic profiling identifies molecular modifiers contributing to proteasome inhibitor resistance in multiple myeloma
SM Gaikwad, VK Hughitt, N Gyabaah-Kessie, M Matera-Vatnick, ...
MOLECULAR CANCER THERAPEUTICS 22 (12), 2023
2023
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