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Molecular mechanisms underlying nucleotide repeat expansion disorders
I Malik, CP Kelley, ET Wang, PK Todd
Nature reviews Molecular cell biology 22 (9), 589-607, 2021
Multicomponent synthesis of 2, 3-dihydrochromeno [4, 3-d] pyrazolo [3, 4-b] pyridine-1, 6-diones: a novel heterocyclic scaffold with antibacterial activity
LV Frolova, I Malik, PY Uglinskii, S Rogelj, A Kornienko, IV Magedov
Tetrahedron letters 52 (49), 6643-6645, 2011
Crystal structure of a transcribing RNA polymerase II complex reveals a complete transcription bubble
CO Barnes, M Calero, I Malik, BW Graham, H Spahr, G Lin, AE Cohen, ...
Molecular cell 59 (2), 258-269, 2015
One-pot multicomponent synthesis of diversely substituted 2-aminopyrroles. A short general synthesis of rigidins A, B, C, and D
LV Frolova, NM Evdokimov, K Hayden, I Malik, S Rogelj, A Kornienko, ...
Organic letters 13 (5), 1118-1121, 2011
Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2, 3-disubstituted indoles and their antimicrobial activity
S Daly, K Hayden, I Malik, N Porch, H Tang, S Rogelj, LV Frolova, ...
Bioorganic & medicinal chemistry letters 21 (16), 4720-4723, 2011
Universal promoter scanning by Pol II during transcription initiation in Saccharomyces cerevisiae
C Qiu, H Jin, I Vvedenskaya, JA Llenas, T Zhao, I Malik, AM Visbisky, ...
Genome biology 21, 1-31, 2020
Wide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo
I Malik, C Qiu, T Snavely, CD Kaplan
Nucleic Acids Research 45 (8), 4431-4451, 2017
Organismal benefits of transcription speed control at gene boundaries
X Leng, M Ivanov, P Kindgren, I Malik, A Thieffry, P Brodersen, A Sandelin, ...
EMBO reports 21 (4), e49315, 2020
Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine
SA Hoose, C Duran, I Malik, S Eslamfam, SC Shasserre, SS Downing, ...
PLoS One 7 (5), e36503, 2012
Non-canonical initiation factors modulate repeat-associated non-AUG translation
KM Green, SL Miller, I Malik, PK Todd
Human molecular genetics 31 (15), 2521-2534, 2022
SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity
I Malik, YJ Tseng, SE Wright, K Zheng, P Ramaiyer, KM Green, PK Todd
EMBO molecular medicine 13 (11), e14163, 2021
Green Chemistry. Reaction of Elemental Phosphorus (P4) and Elemental Sulfur with Protonodonor Reagents: New Methods for the Synthesis of Ammonium Salts of S, S …
ES Batyeva, EK Badeeva, EV Platova, AT Gubaidullin, N Porch, ...
Heteroatom Chemistry 24 (3), 163-167, 2013
Identification of PSMB5 as a genetic modifier of fragile X–associated tremor/ataxia syndrome
HE Kong, J Lim, A Linsalata, Y Kang, I Malik, EG Allen, Y Cao, L Shubeck, ...
Proceedings of the National Academy of Sciences 119 (22), e2118124119, 2022
Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats
YJ Tseng, A Krans, I Malik, X Deng, E Yildirim, S Ovunc, EMH Tank, ...
Nucleic Acids Research, gkae137, 2024
Thiolutin is a direct inhibitor of RNA Polymerase II
C Qiu, I Malik, P Arora, AJ Laperuta, EM Pavlovic, S Ugochuckwu, M Naik, ...
bioRxiv, 2021.05. 05.442806, 2021
Molecular mechanisms underlying nucleotide repeat expansion disorders (June, 10.1038/s41580-021-00382-6, 2021)
I Malik, CP Kelley, ET Wang, PK Todd
Nature Reviews Molecular Cell Biology 22 (9), 644-644, 2021
Thiolutin has complex effects in vivo but is a direct inhibitor of RNA polymerase II in vitro
C Qiu, P Arora, I Malik, AJ Laperuta, EM Pavlovic, S Ugochukwu, M Naik, ...
Nucleic Acids Research, gkad1258, 2024
Dissecting the role of GGGGCC repeat RNA secondary structure in cellular toxicity associated with C9 FTD/ALS
I Malik
Alzheimer's & Dementia 19, e076175, 2023
Dissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGG repeat-associated toxicity in a Drosophila model of FXTAS
I Malik, YJ Tseng, CM Wieland, KM Green, K Zheng, K Calleja, PK Todd
Neurobiology of Disease 184, 106212, 2023
Repeat RNA structure and protein interactions influence RAN translation and neurodegenerative phenotypes in models of FTD and ALS
I Malik, H Swaminathan, S Rouskin, PK Todd
Alzheimer's & Dementia 19, e063489, 2023
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