| IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress AG Lerner, JP Upton, PVK Praveen, R Ghosh, Y Nakagawa, A Igbaria, ... Cell metabolism 16 (2), 250-264, 2012 | 848 | 2012 |
| Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress R Ghosh, L Wang, ES Wang, BGK Perera, A Igbaria, S Morita, K Prado, ... Cell 158 (3), 534-548, 2014 | 468 | 2014 |
| Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells SG Fonseca, S Ishigaki, CM Oslowski, S Lu, KL Lipson, R Ghosh, ... The Journal of clinical investigation 120 (3), 744-755, 2010 | 431 | 2010 |
| Transcriptional regulation of VEGF-A by the unfolded protein response pathway R Ghosh, KL Lipson, KE Sargent, AM Mercurio, JS Hunt, D Ron, F Urano PloS one 5 (3), e9575, 2010 | 291 | 2010 |
| The role of IRE1α in the degradation of insulin mRNA in pancreatic β-cells KL Lipson, R Ghosh, F Urano PloS one 3 (2), e1648, 2008 | 240 | 2008 |
| Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β cells to reverse autoimmune diabetes S Morita, SA Villalta, HC Feldman, AC Register, W Rosenthal, ... Cell metabolism 25 (4), 883-897. e8, 2017 | 210 | 2017 |
| The IRE1α–XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix T Tohmonda, Y Miyauchi, R Ghosh, M Yoda, S Uchikawa, J Takito, ... EMBO reports 12 (5), 451-457, 2011 | 133 | 2011 |
| Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease D Jennings, S Huntwork-Rodriguez, AG Henry, JC Sasaki, R Meisner, ... Science translational medicine 14 (648), eabj2658, 2022 | 112 | 2022 |
| Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes. R Ghosh, K Colon-Negron, FR Papa Molecular Metabolism 27, 560-568, 2019 | 83 | 2019 |
| Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung M Thamsen, R Ghosh, VC Auyeung, A Brumwell, HA Chapman, ... PLoS One 14 (1), e0209824, 2019 | 56 | 2019 |
| Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival PC Moore, JY Qi, M Thamsen, R Ghosh, J Peng, MJ Gliedt, ... Cancer research 79 (24), 6190-6203, 2019 | 30 | 2019 |
| ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR HC Feldman, R Ghosh, VC Auyeung, JL Mueller, JH Kim, ZE Potter, ... Nature Chemical Biology 17 (11), 1148-1156, 2021 | 8 | 2021 |
| Combined modulation of ire1 DJ Maly, BJ Backes, SA Oakes, FR Papa, R Ghosh, L Wang US Patent App. 15/387,463, 2017 | 5 | 2017 |
| Inhibition Of IRE1±Activity Attenuates ER Stress-Induced Pulmonary Fibrosis R Ghosh, MM Giacomini, BJ Backes, D Sheppard, SA Oakes, FR Papa C18. EMERGING PATHWAYS AND SECONDARY HITS IN PULMONARY FIBROSIS, A3923-A3923, 2012 | 1 | 2012 |
Fumihiko UranoSamuel E. Schechter Professor of Medicine, Washington University School of MedicineVerified email at wustl.edu
