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Yasien Sayed, PhD
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Synthesis and evaluation of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors
TO Olomola, R Klein, N Mautsa, Y Sayed, PT Kaye
Bioorganic & medicinal chemistry 21 (7), 1964-1971, 2013
1132013
The hydrophobic lock-and-key intersubunit motif of glutathione transferase A1-1: implications for catalysis, ligandin function and stability
Y Sayed, LA Wallace, HW Dirr
FEBS letters 465 (2-3), 169-172, 2000
802000
Towards the synthesis of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors
TO Olomola, R Klein, KA Lobb, Y Sayed, PT Kaye
Tetrahedron Letters 51 (48), 6325-6328, 2010
762010
Protease inhibition in African subtypes of HIV-1
A Velázquez-Campoy, S Vega, E Fleming, U Bacha, Y Sayed, HW Dirr, ...
Aids Rev 5 (3), 165-171, 2003
632003
Thermodynamics of the ligandin function of human class Alpha glutathione transferase A1-1: energetics of organic anion ligand binding
Y Sayed, JAT Hornby, M Lopez, H Dirr
Biochemical Journal 363 (2), 341-346, 2002
512002
Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance
P Naicker, I Achilonu, S Fanucchi, M Fernandes, MAA Ibrahim, HW Dirr, ...
Journal of Biomolecular Structure and Dynamics 31 (12), 1370-1380, 2013
482013
Active-site mutations in the South African human immunodeficiency virus type 1 subtype C protease have a significant impact on clinical inhibitor binding: kinetic and …
S Mosebi, L Morris, HW Dirr, Y Sayed
Journal of virology 82 (22), 11476-11479, 2008
482008
Comparison of the molecular dynamics and calculated binding free energies for nine FDA‐approved HIV‐1 PR drugs against subtype B and C‐SA HIV PR
SM Ahmed, HG Kruger, T Govender, GEM Maguire, Y Sayed, ...
Chemical biology & drug design 81 (2), 208-218, 2013
472013
Synthesis and structural studies of pentacycloundecane-based HIV-1 PR inhibitors: A hybrid 2D NMR and docking/QM/MM/MD approach
MM Makatini, K Petzold, SN Sriharsha, N Ndlovu, MES Soliman, ...
European journal of medicinal chemistry 46 (9), 3976-3985, 2011
452011
Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease
MM Makatini, K Petzold, SN Sriharsha, MES Soliman, B Honarparvar, ...
Bioorganic & medicinal chemistry letters 21 (8), 2274-2277, 2011
432011
Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study
DC Kuhnert, Y Sayed, S Mosebi, M Sayed, T Sewell, HW Dirr
Journal of molecular biology 349 (4), 825-838, 2005
422005
Characterization of bromosulphophthalein binding to human glutathione S-transferase A1-1: thermodynamics and inhibition kinetics
D Kolobe, Y Sayed, HW Dirr
Biochemical Journal 382 (2), 703-709, 2004
402004
A conserved N-capping motif contributes significantly to the stabilization and dynamics of the C-terminal region of class Alpha glutathione S-transferases
HW Dirr, T Little, DC Kuhnert, Y Sayed
Journal of biological chemistry 280 (20), 19480-19487, 2005
362005
Purification and characterization of naturally occurring HIV-1 (South African subtype C) protease mutants from inclusion bodies
SB Maseko, S Natarajan, V Sharma, N Bhattacharyya, T Govender, ...
Protein expression and purification 122, 90-96, 2016
312016
Binding free energy calculations of nine FDA‐approved protease inhibitors against HIV‐1 subtype C I36T↑ T containing 100 amino acids per monomer
HA Lockhat, JRA Silva, CN Alves, T Govender, J Lameira, GEM Maguire, ...
Chemical biology & drug design 87 (4), 487-498, 2016
312016
Pentacycloundecane derived hydroxy acid peptides: a new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease inhibitors
R Karpoormath, Y Sayed, P Govender, T Govender, HG Kruger, ...
Bioorganic chemistry 40, 19-29, 2012
312012
Residue 219 impacts on the dynamics of the C-terminal region in glutathione transferase A1-1: implications for stability and catalytic and ligandin functions
S Mosebi, Y Sayed, J Burke, HW Dirr
Biochemistry 42 (51), 15326-15332, 2003
312003
V2-directed vaccine-like antibodies from HIV-1 infection identify an additional K169-binding light chain motif with broad ADCC activity
C van Eeden, CK Wibmer, C Scheepers, SI Richardson, M Nonyane, ...
Cell reports 25 (11), 3123-3135. e6, 2018
302018
The intersubunit lock-and-key motif in human glutathione transferase A1-1: role of the key residues Met51 and Phe52 in function and dimer stability
CS Alves, DC Kuhnert, Y Sayed, HW Dirr
Biochemical journal 393 (2), 523-528, 2006
302006
Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors
MM Makatini, K Petzold, PI Arvidsson, B Honarparvar, T Govender, ...
European journal of medicinal chemistry 57, 459-467, 2012
252012
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