Lynn Heasley
Lynn Heasley
Professor, University of Colorado Anschutz Medical Campus
Verified email at
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Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non–small cell lung cancer
RC Doebele, AB Pilling, DL Aisner, TG Kutateladze, AT Le, AJ Weickhardt, ...
Clinical cancer research 18 (5), 1472-1482, 2012
Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein
S Pugazhenthi, A Nesterova, C Sable, KA Heidenreich, LM Boxer, ...
Journal of Biological Chemistry 275 (15), 10761-10766, 2000
Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.
RA Nemenoff, S Winitz, NX Qian, V Van Putten, GL Johnson, LE Heasley
Journal of Biological Chemistry 268 (3), 1960-1964, 1993
Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines
AF Soriano, B Helfrich, DC Chan, LE Heasley, PA Bunn Jr, TC Chou
Cancer Research 59 (24), 6178-6184, 1999
MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts.
SK Gupta, C Gallego, GL Johnson, LE Heasley
Journal of Biological Chemistry 267 (12), 7987-7990, 1992
Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells
L Marek, KE Ware, A Fritzsche, P Hercule, WR Helton, JE Smith, ...
Molecular pharmacology 75 (1), 196-207, 2009
G protein-coupled receptor systems involved in cell growth and oncogenesis
N Dhanasekaran, LE Heasley, GL Johnson
Endocrine reviews 16 (3), 259-270, 1995
Autocrine and paracrine signaling through neuropeptide receptors in human cancer
LE Heasley
Oncogene 20 (13), 1563-1569, 2001
A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop
KE Ware, TK Hinz, E Kleczko, KR Singleton, LA Marek, BA Helfrich, ...
Oncogenesis 2 (3), e39-e39, 2013
Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of Gα12 and Gα13
MV Prasad, JM Dermott, LE Heasley, GL Johnson, N Dhanasekaran
Journal of Biological Chemistry 270 (31), 18655-18659, 1995
Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells
LE Heasley, GL Johnson
Journal of Biological Chemistry 264 (15), 8646-8652, 1989
Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer
LE Heasley, S Thaler, M Nicks, B Price, K Skorecki, RA Nemenoff
Journal of Biological Chemistry 272 (23), 14501-14504, 1997
Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation
RA Winn, L Marek, SY Han, K Rodriguez, N Rodriguez, M Hammond, ...
Journal of Biological Chemistry 280 (20), 19625-19634, 2005
Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer
RMA Linger, RA Cohen, CT Cummings, S Sather, J Migdall-Wilson, ...
Oncogene 32 (29), 3420-3431, 2013
The beta-PDGF receptor induces neuronal differentiation of PC12 cells.
LE Heasley, GL Johnson
Molecular biology of the cell 3 (5), 545-553, 1992
Peroxisome proliferator-activated receptor-γ is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth
M Wick, G Hurteau, C Dessev, D Chan, MW Geraci, RA Winn, LE Heasley, ...
Molecular pharmacology 62 (5), 1207-1214, 2002
c-Jun NH2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation
L Butterfield, B Storey, L Maas, LE Heasley
Journal of Biological Chemistry 272 (15), 10110-10116, 1997
Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation and regulatory T-cell infiltration
A Oweida, MK Hararah, A Phan, D Binder, S Bhatia, S Lennon, ...
Clinical cancer research: an official journal of the American Association …, 2018
Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression
KE Ware, ME Marshall, LR Heasley, L Marek, TK Hinz, P Hercule, ...
PloS one 5 (11), e14117, 2010
FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies
MW Wynes, TK Hinz, D Gao, M Martini, LA Marek, KE Ware, MG Edwards, ...
Clinical cancer research 20 (12), 3299-3309, 2014
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