|Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non–small cell lung cancer|
RC Doebele, AB Pilling, DL Aisner, TG Kutateladze, AT Le, AJ Weickhardt, ...
Clinical cancer research 18 (5), 1472-1482, 2012
|Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein|
S Pugazhenthi, A Nesterova, C Sable, KA Heidenreich, LM Boxer, ...
Journal of Biological Chemistry 275 (15), 10761-10766, 2000
|Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.|
RA Nemenoff, S Winitz, NX Qian, V Van Putten, GL Johnson, LE Heasley
Journal of Biological Chemistry 268 (3), 1960-1964, 1993
|Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines|
AF Soriano, B Helfrich, DC Chan, LE Heasley, PA Bunn Jr, TC Chou
Cancer Research 59 (24), 6178-6184, 1999
|MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts.|
SK Gupta, C Gallego, GL Johnson, LE Heasley
Journal of Biological Chemistry 267 (12), 7987-7990, 1992
|Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells|
L Marek, KE Ware, A Fritzsche, P Hercule, WR Helton, JE Smith, ...
Molecular pharmacology 75 (1), 196-207, 2009
|G protein-coupled receptor systems involved in cell growth and oncogenesis|
N Dhanasekaran, LE Heasley, GL Johnson
Endocrine reviews 16 (3), 259-270, 1995
|Autocrine and paracrine signaling through neuropeptide receptors in human cancer|
Oncogene 20 (13), 1563-1569, 2001
|A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop|
KE Ware, TK Hinz, E Kleczko, KR Singleton, LA Marek, BA Helfrich, ...
Oncogenesis 2 (3), e39-e39, 2013
|Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of Gα12 and Gα13|
MV Prasad, JM Dermott, LE Heasley, GL Johnson, N Dhanasekaran
Journal of Biological Chemistry 270 (31), 18655-18659, 1995
|Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells|
LE Heasley, GL Johnson
Journal of Biological Chemistry 264 (15), 8646-8652, 1989
|Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer|
LE Heasley, S Thaler, M Nicks, B Price, K Skorecki, RA Nemenoff
Journal of Biological Chemistry 272 (23), 14501-14504, 1997
|Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation|
RA Winn, L Marek, SY Han, K Rodriguez, N Rodriguez, M Hammond, ...
Journal of Biological Chemistry 280 (20), 19625-19634, 2005
|Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer|
RMA Linger, RA Cohen, CT Cummings, S Sather, J Migdall-Wilson, ...
Oncogene 32 (29), 3420-3431, 2013
|The beta-PDGF receptor induces neuronal differentiation of PC12 cells.|
LE Heasley, GL Johnson
Molecular biology of the cell 3 (5), 545-553, 1992
|Peroxisome proliferator-activated receptor-γ is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth|
M Wick, G Hurteau, C Dessev, D Chan, MW Geraci, RA Winn, LE Heasley, ...
Molecular pharmacology 62 (5), 1207-1214, 2002
|c-Jun NH2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation|
L Butterfield, B Storey, L Maas, LE Heasley
Journal of Biological Chemistry 272 (15), 10110-10116, 1997
|Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation and regulatory T-cell infiltration|
A Oweida, MK Hararah, A Phan, D Binder, S Bhatia, S Lennon, ...
Clinical cancer research: an official journal of the American Association …, 2018
|Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression|
KE Ware, ME Marshall, LR Heasley, L Marek, TK Hinz, P Hercule, ...
PloS one 5 (11), e14117, 2010
|FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies|
MW Wynes, TK Hinz, D Gao, M Martini, LA Marek, KE Ware, MG Edwards, ...
Clinical cancer research 20 (12), 3299-3309, 2014