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Cihan Aydin
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The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors
KP Romano, A Ali, C Aydin, D Soumana, A Özen, LM Deveau, C Silver, ...
PLoS Pathog 8 (7), e1002832, 2012
2462012
The photolyase/cryptochrome family of proteins as DNA repair enzymes and transcriptional repressors
IH Kavakli, I Baris, M Tardu, Ş Gül, H Öner, S Çal, S Bulut, D Yarparvar, ...
Photochemistry and photobiology 93 (1), 93-103, 2017
882017
Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance
A Ali, C Aydin, R Gildemeister, KP Romano, H Cao, A Özen, D Soumana, ...
ACS chemical biology 8 (7), 1469-1478, 2013
712013
Gene editing and RNAi approaches for COVID-19 diagnostics and therapeutics
B Berber, C Aydin, F Kocabas, G Guney-Esken, K Yilancioglu, ...
Gene therapy 28 (6), 290-305, 2021
482021
Structural and thermodynamic effects of macrocyclization in HCV NS3/4A inhibitor MK-5172
DI Soumana, N Kurt Yilmaz, KL Prachanronarong, C Aydin, A Ali, ...
ACS chemical biology 11 (4), 900-909, 2016
452016
Human CRY1 variants associate with attention deficit/hyperactivity disorder
OE Onat, ME Kars, Ş Gül, K Bilguvar, Y Wu, A Özhan, C Aydın, AN Başak, ...
The Journal of Clinical Investigation 130 (7), 2020
392020
The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities
C Aydin, S Mukherjee, AM Hanson, DN Frick, CA Schiffer
Protein Science 22 (12), 1786-1798, 2013
252013
Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling
S Muratcioglu, C Aydin, E Odabasi, ES Ozdemir, EN Firat-Karalar, H Jang, ...
Journal of Molecular Biology 432 (4), 1199-1215, 2020
202020
The Arg-293 of Cryptochrome1 is responsible for the allosteric regulation of CLOCK-CRY1 binding in circadian rhythm
S Gul, C Aydin, O Ozcan, B Gurkan, S Surme, I Baris, IH Kavakli
Journal of Biological Chemistry 295 (50), 17187-17199, 2020
142020
Simultaneously targeting the NS3 protease and helicase activities for more effective hepatitis C virus therapy
J Ndjomou, MJ Corby, NL Sweeney, AM Hanson, C Aydin, A Ali, ...
ACS chemical biology 10 (8), 1887-1896, 2015
112015
Resistance from Afar: Distal Mutation V36M Allosterically Modulates the Active Site to Accentuate Drug Resistance in HCV NS3/4A Protease
A Özen, KH Lin, KP Romano, D Tavella, A Newton, CJ Petropoulos, ...
bioRxiv, 452284, 2018
42018
Expression analyses of soluble starch synthase and starch branching enzyme isoforms in stem and leaf tissues under different photoperiods in lentil (Lens culinaris Medik.)
YC Gercek, K Boztas, C Aydin, H Morgil, I Baris, GC Oz, I Tulum
Biologia 77 (2), 593-607, 2022
12022
TW68, cryptochromes stabilizer, regulates fasting blood glucose levels in diabetic ob/ob and high fat-diet-induced obese mice
S Surme, C Ergun, S Gul, YK Akyel, ZM Gul, O Ozcan, OS Ipek, BA Akarlar, ...
Biochemical Pharmacology 218, 115896, 2023
2023
Hepatitis C Virus Non-Structural Protein 3/4A: A Tale of Two Domains: A Dissertation
C Aydin
2012
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Articles 1–14