Follow
Gary Wilkinson
Gary Wilkinson
Director Clinical Pharmacology, Bayer, Germany
Verified email at bayer.com
Title
Cited by
Cited by
Year
Discovery and characterization of AZD6738, a potent inhibitor of ataxia telangiectasia mutated and Rad3 related (ATR) kinase with application as an anticancer agent
KM Foote, JWM Nissink, T McGuire, P Turner, S Guichard, JWT Yates, ...
Journal of medicinal chemistry 61 (22), 9889-9907, 2018
2322018
First-in-human trial of the oral ataxia telangiectasia and Rad3-related (ATR) inhibitor BAY 1895344 in patients with advanced solid tumors
DSP Tan, J de Bono, A Caldwell, R, Terbuch, BC Goh, V Heong, N Haris, ...
Asian Society of Gynecologic Oncology - 6th Biennial Meeting, 2019
1652019
First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due …
S Postel-Vinay, K Herbschleb, C Massard, V Woodcock, JC Soria, ...
European Journal of Cancer 109, 103-110, 2019
1012019
Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent
GP Wilkinson, JP Taylor, S Shnyder, P Cooper, PW Howard, DE Thurston, ...
Investigational New Drugs 22, 231-240, 2004
822004
Drug–drug interaction potential of darolutamide: in vitro and clinical studies
C Zurth, M Koskinen, R Fricke, O Prien, T Korjamo, K Graudenz, K Denner, ...
European Journal of Drug Metabolism and Pharmacokinetics 44, 747-759, 2019
722019
Pharmacokinetics, metabolism & glutathione reactivity of SJG-136
GP Wilkinson, PM Loadman, TC Jenkins, J Taylor, SD Shnyder, ...
BRITISH JOURNAL OF CANCER 88 (Br J Cancer 88: S25-S54; doi:10.1038/sj.bjc …, 2003
582003
Pharmacokinetic and intracellular pharmacological characteristics of the novel pyrrolobenzodiazepine (PBD) dimer SJG-136
GP Wilkinson, P Loadman, J Taylor, TC Jenkins, D Swaine, JA Double, ...
Proceeding of the American Association for Cancer Research 44, 1634-, 2003
582003
Safety and efficacy of BAY1436032 in IDH1-mutant AML: phase I study results
M Heuser, N Palmisiano, I Mantzaris, A Mims, C DiNardo, LR Silverman, ...
Leukemia 34 (11), 2903-2913, 2020
462020
Discovery of AZD6738, a potent and selective inhibitor with the potential to test the clinical efficacy of ATR kinase inhibition in cancer patients
CD Jones, K Blades, KM Foote, SM Guichard, PJ Jewsbury, T McGuire, ...
Abstracts of the AACR Annual Meeting; 2013/04; Washington, DC, Abstract nr 2348, 2013
422013
First-in-human trial of the oral ataxia telangiectasia and Rad3-related (ATR) inhibitor BAY 1895344 in patients (pts) with advanced solid tumors.
JS De Bono, DSP Tan, R Caldwell, A Terbuch, BC Goh, V Heong, ...
Journal of Clinical Oncology 37 (15_suppl), 3007-3007, 2019
322019
First-in-human phase I dose escalation study of the Bromodomain and Extra-Terminal motif (BET) inhibitor BAY 1238097 in subjects with advanced malignancies
S Postel-Vinay, K Herbschleb, C Massard, V Woodcock, M Ocker, ...
European Journal of Cancer 69, S7-S8, 2016
192016
Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40
MJ Waring, DJ Baker, SNL Bennett, AG Dossetter, M Fenwick, R Garcia, ...
MedChemComm 6 (6), 1024-1029, 2015
152015
Phase 1 Dose Escalation Study of the Allosteric AKT Inhibitor BAY 1125976 in Advanced Solid Cancer—Lack of Association between Activating AKT Mutation and AKT Inhibition …
A Schneeweiss, D Hess, M Joerger, A ,Varga, S Moulder, ...
Cancers 11 (12), 1987, 2019
142019
Chronic glucokinase activator treatment at clinically translatable exposures gives durable glucose lowering in two animal models of type 2 diabetes
DJ Baker, GP Wilkinson, AM Atkinson, HB Jones, M Coghlan, AD Charles, ...
British Journal of Pharmacology 171 (7), 1642–1654, 2014
132014
Characterisation of the heterozygous glucokinase knockout mouse as a translational disease model for glucose control in type 2 diabetes
DJ Baker, AM Atkinson, GP Wilkinson, GJ Coope, AD Charles, B Leighton
British Journal of Pharmacology 171 (7), 1629–1641, 2014
132014
Abstract CT006: Phase Ib expansion trial of the safety and efficacy of the oral ataxia telangiectasia and Rad3-related (ATR) inhibitor elimusertib in advanced solid tumors with …
TA Yap, DS Tan, A Stathis, GI Shapiro, S Iwasa, M Joerger, J Zhang, ...
Cancer Research 82 (12_Supplement), CT006-CT006, 2022
122022
Drug-drug interaction (DDI) of darolutamide with cytochrome P450 (CYP) and P-glycoprotein (P-gp) substrates: Results from clinical and in vitro studies.
C Zurth, K Graudenz, K Denner, T Korjamo, R Fricke, G Wilkinson, F Seitz, ...
Journal of Clinical Oncology 37 (7_suppl), 297-297, 2019
92019
Open access liquid chromatography/tandem mass spectrometry: Implementation of a fully quantitative system in a drug discovery laboratory
JG Swales, G Wilkinson, R Gallagher, C Hammond, C O’Donnell, R Peter
International Journal of High Throughput Screening, 1-14, 2010
92010
Matched triplicate design sets in the optimisation of glucokinase activators-maximising medicinal chemistry information content
MJ Waring, SNL Bennett, S Boyd, L Campbell, RDM Davies, S Gerhardt, ...
MedChemComm 4 (4), 657-662, 2013
82013
Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets–the discovery of AZD3651 and AZD9485
MJ Waring, SNL Bennett, S Boyd, L Campbell, RDM Davies, ...
MedChemComm 4 (4), 663-668, 2013
82013
The system can't perform the operation now. Try again later.
Articles 1–20