| Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase T Paquet, C Le Manach, DG Cabrera, Y Younis, PP Henrich, TS Abraham, ... Science translational medicine 9 (387), 2017 | 244 | 2017 |
| Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination J Reader, M Botha, A Theron, SB Lauterbach, C Rossouw, D Engelbrecht, ... Malaria journal 14 (1), 1-17, 2015 | 120 | 2015 |
| Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box J Reader, ME van der Watt, D Taylor, C Le Manach, N Mittal, S Ottilie, ... Nature communications 12 (1), 1-15, 2021 | 67 | 2021 |
| UCT943, a next-generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria C Brunschwig, N Lawrence, D Taylor, E Abay, M Njoroge, GS Basarab, ... Antimicrobial agents and chemotherapy 62 (9), e00012-18, 2018 | 62 | 2018 |
| Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites N Coetzee, H von Grüning, D Opperman, M van der Watt, J Reader, ... Scientific reports 10 (1), 1-11, 2020 | 58 | 2020 |
| Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in … K Singh, J Okombo, C Brunschwig, F Ndubi, L Barnard, C Wilkinson, ... Journal of medicinal chemistry 60 (4), 1432-1448, 2017 | 52 | 2017 |
| Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life cycle C Le Manach, AT Nchinda, T Paquet, D Gonzàlez Cabrera, Y Younis, ... Journal of medicinal chemistry 59 (21), 9890-9905, 2016 | 51 | 2016 |
| Artemisone and artemiside are potent panreactive antimalarial agents that also synergize redox imbalance in Plasmodium falciparum transmissible gametocyte stages D Coertzen, J Reader, M Van Der Watt, SH Nondaba, L Gibhard, ... Antimicrobial agents and chemotherapy 62 (8), e02214-17, 2018 | 43 | 2018 |
| Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites RM Beteck, R Seldon, D Coertzen, ME Van Der Watt, J Reader, ... Communications Chemistry 1 (1), 1-11, 2018 | 33 | 2018 |
| A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure–Activity Relationship … C Le Manach, T Paquet, C Brunschwig, M Njoroge, Z Han, ... Journal of medicinal chemistry 58 (21), 8713-8722, 2015 | 30 | 2015 |
| Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials ME van der Watt, J Reader, A Churchyard, SH Nondaba, SB Lauterbach, ... Journal of Antimicrobial Chemotherapy 73 (5), 1279-1290, 2018 | 24 | 2018 |
| Benzimidazole Derivatives Are Potent against Multiple Life Cycle Stages of Plasmodium falciparum Malaria Parasites M Leshabane, GA Dziwornu, D Coertzen, J Reader, P Moyo, ... ACS Infectious Diseases, 2021 | 23 | 2021 |
| Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure–Activity Relationship and In Vivo … GA Dziwornu, D Coertzen, M Leshabane, CM Korkor, CK Cloete, ... Journal of Medicinal Chemistry 64 (8), 5198-5215, 2021 | 20 | 2021 |
| Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products P Moyo, W Shamburger, ME van der Watt, J Reader, ACC De Sousa, ... International Journal for Parasitology: Drugs and Drug Resistance 13, 51-58, 2020 | 19 | 2020 |
| Multistage antiplasmodium activity of astemizole analogues and inhibition of hemozoin formation as a contributor to their mode of action M Kumar, J Okombo, D Mambwe, D Taylor, N Lawrence, J Reader, ... ACS infectious diseases 5 (2), 303-315, 2018 | 19 | 2018 |
| Optimal 10-aminoartemisinins with potent transmission-blocking capabilities for new artemisinin combination therapies–activities against blood stage P. falciparum including … HN Wong, V Padín-Irizarry, ME van der Watt, J Reader, W Liebenberg, ... Frontiers in chemistry 7, 901, 2020 | 17 | 2020 |
| Identification and profiling of a novel diazaspiro [3.4] octane chemical series active against multiple stages of the human malaria parasite Plasmodium falciparum and … C Le Manach, J Dam, JG Woodland, G Kaur, LP Khonde, C Brunschwig, ... Journal of Medicinal Chemistry 64 (4), 2291-2309, 2021 | 16 | 2021 |
| Activities of 11‐azaartemisinin and N‐sulfonyl derivatives against asexual and transmissible malaria parasites R Harmse, D Coertzen, HN Wong, FJ Smit, ME Van der Watt, J Reader, ... Wiley, 2017 | 16 | 2017 |
| A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail PB Burger, M Williams, J Sprenger, SB Reeksting, M Botha, IB Müller, ... Malaria journal 14 (1), 1-18, 2015 | 15 | 2015 |
| Identification of 2, 4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model A Horatscheck, A Andrijevic, AT Nchinda, C Le Manach, T Paquet, ... Journal of medicinal chemistry 63 (21), 13013-13030, 2020 | 13 | 2020 |
