Mark Cushman
Mark Cushman
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Structures of three classes of anticancer agents bound to the human topoisomerase I− DNA covalent complex
BL Staker, MD Feese, M Cushman, Y Pommier, D Zembower, L Stewart, ...
Journal of medicinal chemistry 48 (7), 2336-2345, 2005
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization
M Cushman, D Nagarathnam, D Gopal, AK Chakraborti, CM Lin, E Hamel
Journal of medicinal chemistry 34 (8), 2579-2588, 1991
Synthesis and evaluation of analogs of (Z)-1-(4-methoxyphenyl)-2-(3, 4, 5-trimethoxyphenyl) ethene as potential cytotoxic and antimitotic agents
M Cushman, D Nagarathnam, D Gopal, HM He, CM Lin, E Hamel
Journal of medicinal chemistry 35 (12), 2293-2306, 1992
Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin …
M Cushman, HM He, JA Katzenellenbogen, CM Lin, E Hamel
Journal of medicinal chemistry 38 (12), 2041-2049, 1995
Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogs
M Cushman, D Nagarathnam, DL Burg, RL Geahlen
Journal of medicinal chemistry 34 (2), 798-806, 1991
Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogs of piceatannol
K Thakkar, RL Geahlen, M Cushman
Journal of medicinal chemistry 36 (20), 2950-2955, 1993
Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites
J Hoshino, EJ Park, TP Kondratyuk, L Marler, JM Pezzuto, ...
Journal of medicinal chemistry 53 (13), 5033-5043, 2010
Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison
G Kohlhagen, KD Paull, M Cushman, P Nagafuji, Y Pommier
Molecular Pharmacology 54 (1), 50-58, 1998
Synthesis of New Indeno[1,2-c]isoquinolines:  Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors
M Cushman, M Jayaraman, JA Vroman, AK Fukunaga, BM Fox, ...
Journal of medicinal chemistry 43 (20), 3688-3698, 2000
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
C Marchand, S Antony, KW Kohn, M Cushman, A Ioanoviciu, BL Staker, ...
Molecular cancer therapeutics 5 (2), 287-295, 2006
Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons
D Strumberg, Y Pommier, K Paull, M Jayaraman, P Nagafuji, M Cushman
Journal of medicinal chemistry 42 (3), 446-457, 1999
Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen
M Nagarajan, X Xiao, S Antony, G Kohlhagen, Y Pommier, M Cushman
Journal of medicinal chemistry 46 (26), 5712-5724, 2003
The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives
Y Pommier, M Cushman
Molecular cancer therapeutics 8 (5), 1008-1014, 2009
Condensation of imines with homophthalic anhydrides. A convergent synthesis of cis-and trans-13-methyltetrahydroprotoberberines
M Cushman, J Gentry, FW Dekow
The Journal of organic chemistry 42 (7), 1111-1116, 1977
Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly
E Hamel, BW Day, JH Miller, MK Jung, PT Northcote, AK Ghosh, ...
Molecular pharmacology 70 (5), 1555-1564, 2006
Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogs: direct correlation of antiviral potency with molecular weight
M Cushman, P Wang, SH Chang, C Wild, E De Clercq, D Schols, ...
Journal of medicinal chemistry 34 (1), 329-337, 1991
Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings
M Nagarajan, A Morrell, BC Fort, MR Meckley, S Antony, G Kohlhagen, ...
Journal of medicinal chemistry 47 (23), 5651-5661, 2004
Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance
S Antony, KK Agama, ZH Miao, K Takagi, MH Wright, AI Robles, ...
Cancer research 67 (21), 10397-10405, 2007
Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against …
S Antony, M Jayaraman, G Laco, G Kohlhagen, KW Kohn, M Cushman, ...
Cancer Research 63 (21), 7428-7435, 2003
Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src
M Cushman, H Zhu, RL Geahlen, AJ Kraker
Journal of medicinal chemistry 37 (20), 3353-3362, 1994
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