| Retinoids in cancer therapy and chemoprevention: promise meets resistance SJ Freemantle, MJ Spinella, E Dmitrovsky Oncogene 22 (47), 7305-7315, 2003 | 401 | 2003 |
| A novel synthetic oleanane triterpenoid, 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity N Suh, Y Wang, T Honda, GW Gribble, E Dmitrovsky, WF Hickey, ... Cancer research 59 (2), 336-341, 1999 | 393 | 1999 |
| Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation MJ Spinella, SJ Freemantle, D Sekula, JH Chang, AJ Christie, ... Journal of Biological Chemistry 274 (31), 22013-22018, 1999 | 198 | 1999 |
| A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embyronal carcinoma JS Kerley-Hamilton, AM Pike, N Li, J DiRenzo, MJ Spinella Oncogene 24 (40), 6090-6100, 2005 | 172 | 2005 |
| Distinguishing between Folate Receptor-α-mediated Transport and Reduced Folate Carrier-mediated Transport in L1210 Leukemia Cells (∗) MJ Spinella, KE Brigle, EE Sierra, ID Goldman Journal of Biological Chemistry 270 (14), 7842-7849, 1995 | 153 | 1995 |
| Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors H Li, P Cherukuri, N Li, V Cowling, M Spinella, M Cole, AK Godwin, ... Cancer research 67 (2), 501-510, 2007 | 150 | 2007 |
| Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate-receptor-positive tumor cells for lysis. DM Kranz, TA Patrick, KE Brigle, MJ Spinella, EJ Roy Proceedings of the National Academy of Sciences 92 (20), 9057-9061, 1995 | 139 | 1995 |
| Characterization of a Mutation in the Reduced Folate Carrier in a Transport Defective L1210 Murine Leukemia Cell Line (∗) KE Brigle, MJ Spinella, EE Sierra, ID Goldman Journal of Biological Chemistry 270 (39), 22974-22979, 1995 | 136 | 1995 |
| Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma SJ Freemantle, JS Kerley, SL Olsen, RH Gross, MJ Spinella Oncogene 21 (18), 2880-2889, 2002 | 128 | 2002 |
| Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells P Mao, MP Hever, LM Niemaszyk, JM Haghkerdar, EG Yanco, D Desai, ... Journal of Biological Chemistry 286 (22), 19381-19391, 2011 | 113 | 2011 |
| High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors MJ Beyrouthy, KM Garner, MP Hever, SJ Freemantle, A Eastman, ... Cancer research 69 (24), 9360-9366, 2009 | 109 | 2009 |
| Design and synthesis of a specific endothelin 1 antagonist: effects on pulmonary vasoconstriction. MJ Spinella, AB Malik, J Everitt, TT Andersen Proceedings of the National Academy of Sciences 88 (16), 7443-7446, 1991 | 104 | 1991 |
| Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells KE Brigle, MJ Spinella, EH Westin, ID Goldman Biochemical pharmacology 47 (2), 337-345, 1994 | 97 | 1994 |
| Serine/threonine kinase 17A is a novel candidate for therapeutic targeting in glioblastoma P Mao, MP Hever-Jardine, GJ Rahme, E Yang, J Tam, A Kodali, B Biswal, ... PLoS One 8 (11), e81803, 2013 | 85 | 2013 |
| pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells: further evidence for a third route mediated at low pH EE Sierra, KE Brigle, MJ Spinella, ID Goldman Biochemical pharmacology 53 (2), 223-231, 1997 | 84 | 1997 |
| Transcriptional activation of the nuclear receptor corepressor RIP140 by retinoic acid: a potential negative-feedback regulatory mechanism JS Kerley, SL Olsen, SJ Freemantle, MJ Spinella Biochemical and biophysical research communications 285 (4), 969-975, 2001 | 80 | 2001 |
| Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity CJ Giuliano, JS Kerley-Hamilton, T Bee, SJ Freemantle, R Manickaratnam, ... Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1731 (1 …, 2005 | 79 | 2005 |
| Retinoic acid activates p53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of p53 transactivation function JC Curtin, KH Dragnev, D Sekula, AJ Christie, E Dmitrovsky, MJ Spinella Oncogene 20 (20), 2559-2569, 2001 | 67 | 2001 |
| Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine C Albany, MP Hever-Jardine, KM von Herrmann, CY Yim, J Tam, ... Oncotarget 8 (2), 2949, 2017 | 64 | 2017 |
| Cyclin proteolysis as a retinoid cancer prevention mechanism KH Dragnev, SJ Freemantle, MJ Spinella, E Dmitrovsky Annals of the New York Academy of Sciences 952 (1), 13-22, 2001 | 64 | 2001 |
