| A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung GS Forkuo, AN Nieman, R Kodali, NM Zahn, G Li, MS Rashid Roni, ... Molecular pharmaceutics 15 (5), 1766-1777, 2018 | 47 | 2018 |
| Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments GS Forkuo, ML Guthrie, NY Yuan, AN Nieman, R Kodali, R Jahan, ... Molecular pharmaceutics 13 (6), 2026-2038, 2016 | 38 | 2016 |
| Targeting the γ-aminobutyric acid A receptor α4 subunit in airway smooth muscle to alleviate bronchoconstriction GT Yocum, G Gallos, Y Zhang, R Jahan, MR Stephen, Z Varagic, ... American journal of respiratory cell and molecular biology 54 (4), 546-553, 2016 | 36 | 2016 |
| The α2, 3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats JM Witkin, R Cerne, PG Davis, KB Freeman, JM Do Carmo, JK Rowlett, ... Pharmacology Biochemistry and Behavior 180, 22-31, 2019 | 32 | 2019 |
| Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators GS Forkuo, AN Nieman, NY Yuan, R Kodali, OB Yu, NM Zahn, R Jahan, ... Molecular pharmaceutics 14 (6), 2088-2098, 2017 | 32 | 2017 |
| Optimization of substituted imidazobenzodiazepines as novel asthma treatments R Jahan, MR Stephen, GS Forkuo, R Kodali, ML Guthrie, AN Nieman, ... European journal of medicinal chemistry 126, 550-560, 2017 | 30 | 2017 |
| The positive allosteric modulator of α2/3-containing GABAA receptors, KRM-II-81, is active in pharmaco-resistant models of epilepsy and reduces hyperexcitability after … JM Witkin, G Li, LK Golani, W Xiong, JL Smith, X Ping, F Rashid, R Jahan, ... Journal of Pharmacology and Experimental Therapeutics 372 (1), 83-94, 2020 | 24 | 2020 |
| Improved synthesis of anxiolytic, anticonvulsant, and antinociceptive α2/α3-GABA (A)-ergic receptor subtype selective ligands as promising agents to treat anxiety, epilepsy … G Li, LK Golani, R Jahan, F Rashid, JM Cook Synthesis 50 (20), 4124-4132, 2018 | 17 | 2018 |
| Preclinical efficacy and selectivity of vaccines targeting fentanyl, alfentanil, sufentanil, and acetylfentanyl in rats C Baehr, C Robinson, A Kassick, R Jahan, V Gradinati, SE Averick, ... ACS omega 7 (19), 16584-16592, 2022 | 14 | 2022 |
| Efficacy and selectivity of monovalent and bivalent vaccination strategies to protect against exposure to carfentanil, fentanyl, and their mixtures in rats B Crouse, MM Wu, V Gradinati, AJ Kassick, D Song, R Jahan, S Averick, ... ACS Pharmacology & Translational Science 5 (5), 331-343, 2022 | 11 | 2022 |
| Imidazodiazepine anticonvulsant, KRM-II-81, produces novel, non-diazepam-like antiseizure effects DE Knutson, JL Smith, X Ping, X Jin, LK Golani, G Li, ... ACS Chemical Neuroscience 11 (17), 2624-2637, 2020 | 10 | 2020 |
| GABAA Receptor Subtypes and the Abuse‐Related Effects of Ethanol in Rhesus Monkeys: Experiments with Selective Positive Allosteric Modulators LF Berro, D Rüedi‐Bettschen, JE Cook, LK Golani, G Li, R Jahan, ... Alcoholism: Clinical and Experimental Research 43 (5), 791-802, 2019 | 10 | 2019 |
| Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding JV Rodarte, C Baehr, D Hicks, TL Liban, C Weidle, PB Rupert, R Jahan, ... Structure 31 (1), 20-32. e5, 2023 | 8 | 2023 |
| The value of human epileptic tissue in the characterization and development of novel antiepileptic drugs: The example of CERC-611 and KRM-II-81 JM Witkin, X Ping, C Mouser, X Jin, J Hobbs, VVNPB Tiruveedhula, G Li, ... Brain research 1722, 146356, 2019 | 8 | 2019 |
| A new pharmacological approach for asthma through tissue-specific modulation of the GABA (A) receptor LA Arnold, GS Forkuo, AN Nieman, BY Olivia, ML Guthrie, NY Yuan, ... Journal of Allergy and Clinical Immunology 137 (2), AB393, 2016 | 6 | 2016 |
| GABA (A) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma AE ARNOLD, DC Stafford, JM Cook, CW Emala, G FORKUO, R JAHAN, ... | 3 | 2018 |
| New oral treatments for asthma through tissue-specific modulation of the GABAA receptor L Arnold, G Forkuo, A Nieman, BY Olivia, ML Guthrie, R Kodali, N Yuan, ... Journal of Allergy and Clinical Immunology 139 (2), AB9, 2017 | 2 | 2017 |
| The Positive Allosteric Modulator of Alpha-2/3-Containing γ-Aminobutyric Acid Type A Receptors, KRM-II-81, Is Active in Pharmacoresistant Models of Epilepsy and in Human … JL Smith, X Ping, X Jin, LK Golani, G Li, F Rashid, R Jahan, JM Cook, ... Neurosurgery 66, 310-697, 2019 | 1 | 2019 |
| Gaba (a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma AE Arnold, DC Stafford, JM Cook, CW Emala, G Forkuo, R Jahan, ... US Patent App. 17/886,403, 2023 | | 2023 |
| Substituted benzo [f] imidazo [1, 5-a][1, 4] diazepines as GABA (a) receptor modulators AE Arnold, DC Stafford, JM Cook, CW Emala, G Forkuo, R Jahan, ... US Patent 11,447,495, 2022 | | 2022 |
