| PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes VK Mootha, CM Lindgren, KF Eriksson, A Subramanian, S Sihag, J Lehar, ... Nature genetics 34 (3), 267-273, 2003 | 9920 | 2003 |
| The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity J Barretina, G Caponigro, N Stransky, K Venkatesan, AA Margolin, S Kim, ... Nature 483 (7391), 603-607, 2012 | 7701 | 2012 |
| Next-generation characterization of the cancer cell line encyclopedia M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ... Nature 569 (7757), 503-508, 2019 | 2362 | 2019 |
| High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response H Gao, JM Korn, S Ferretti, JE Monahan, Y Wang, M Singh, C Zhang, ... Nature medicine 21 (11), 1318-1325, 2015 | 1302 | 2015 |
| Multi-target therapeutics: when the whole is greater than the sum of the parts GR Zimmermann, J Lehar, CT Keith Drug discovery today 12 (1-2), 34-42, 2007 | 1259 | 2007 |
| Time series analysis with clean-part one-derivation of a spectrum DH Roberts, J Lehár, JW Dreher ASTRONOMICAL JOURNAL V. 93, NO. 4/APR, P. 968, 1987 93, 968, 1987 | 1230 | 1987 |
| Synergistic drug combinations tend to improve therapeutically relevant selectivity J Lehár, AS Krueger, W Avery, AM Heilbut, LM Johansen, ER Price, ... Nature biotechnology 27 (7), 659-666, 2009 | 977 | 2009 |
| Systematic discovery of multicomponent therapeutics AA Borisy, PJ Elliott, NW Hurst, MS Lee, J Lehár, ER Price, G Serbedzija, ... Proceedings of the National Academy of Sciences 100 (13), 7977-7982, 2003 | 752 | 2003 |
| Probing the coevolution of supermassive black holes and galaxies using gravitationally lensed quasar hosts CY Peng, CD Impey, HW Rix, CS Kochanek, CR Keeton, EE Falco, ... The Astrophysical Journal 649 (2), 616, 2006 | 484 | 2006 |
| Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials C Fritsch, A Huang, C Chatenay-Rivauday, C Schnell, A Reddy, M Liu, ... Molecular cancer therapeutics 13 (5), 1117-1129, 2014 | 469 | 2014 |
| CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors SR Vora, D Juric, N Kim, M Mino-Kenudson, T Huynh, C Costa, ... Cancer cell 26 (1), 136-149, 2014 | 442 | 2014 |
| Automated deep-neural-network surveillance of cranial images for acute neurologic events JJ Titano, M Badgeley, J Schefflein, M Pain, A Su, M Cai, N Swinburne, ... Nature medicine 24 (9), 1337-1341, 2018 | 395 | 2018 |
| FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection LM Johansen, JM Brannan, SE Delos, CJ Shoemaker, A Stossel, C Lear, ... Science translational medicine 5 (190), 190ra79-190ra79, 2013 | 378 | 2013 |
| Dust and extinction curves in galaxies with z> 0: The interstellar medium of gravitational lens galaxies EE Falco, CD Impey, CS Kochanek, J Lehár, BA McLeod, HW Rix, ... The Astrophysical Journal 523 (2), 617, 1999 | 333 | 1999 |
| Chemical combination effects predict connectivity in biological systems J Lehár, GR Zimmermann, AS Krueger, RA Molnar, JT Ledell, AM Heilbut, ... Molecular systems biology 3 (1), 80, 2007 | 329 | 2007 |
| Pharmacogenomic agreement between two cancer cell line data sets Cancer Cell Line Encyclopedia Consortium, ... Nature 528 (7580), 84-87, 2015 | 285 | 2015 |
| Hubble Space Telescope observations of 10 two-image gravitational lenses J Lehár, EE Falco, CS Kochanek, BA McLeod, JA Munoz, CD Impey, ... The Astrophysical Journal 536 (2), 584, 2000 | 261 | 2000 |
| A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity LM Johansen, LE DeWald, CJ Shoemaker, BG Hoffstrom, ... Science translational medicine 7 (290), 290ra89-290ra89, 2015 | 256 | 2015 |
| The fundamental plane of gravitational lens galaxies and the evolution of early-type galaxies in low-density environments CS Kochanek, EE Falco, CD Impey, J Lehár, BA McLeod, HW Rix, ... The Astrophysical Journal 543 (1), 131, 2000 | 218 | 2000 |
| Combination chemical genetics J Lehár, BR Stockwell, G Giaever, C Nislow Nature chemical biology 4 (11), 674-681, 2008 | 201 | 2008 |
Chris ImpeyProfessor of Astronomy, University of ArizonaVerified email at as.arizona.edu
