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S. Margaret Sunitha
S. Margaret Sunitha
Research Scientist - MGH Cardiology Department
Verified email at broadinstitute.org
Title
Cited by
Cited by
Year
The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
S Nag, DV Trivedi, SS Sarkar, AS Adhikari, MS Sunitha, S Sutton, ...
Nature structural & molecular biology 24 (6), 525-533, 2017
1952017
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
X Li, Z Li, H Zhou, SM Gaynor, Y Liu, H Chen, R Sun, R Dey, DK Arnett, ...
Nature genetics 52 (9), 969-983, 2020
1602020
Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation
JR Homburger, EM Green, C Caleshu, MS Sunitha, RE Taylor, ...
Proceedings of the National Academy of Sciences 113 (24), 6701-6706, 2016
1192016
Genome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties
AK Upadhyay, AR Chacko, A Gandhimathi, P Ghosh, K Harini, AP Joseph, ...
BMC plant biology 15, 1-20, 2015
1102015
Structural and functional insights on the Myosin superfamily
DP Syamaladevi, JA Spudich, R Sowdhamini
Bioinformatics and biology insights 6, BBI. S8451, 2012
892012
Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies
TM Gupte, F Haque, B Gangadharan, MS Sunitha, S Mukherjee, ...
Journal of Biological Chemistry 290 (11), 7003-7015, 2015
502015
A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies
Z Li, X Li, H Zhou, SM Gaynor, MS Selvaraj, T Arapoglou, C Quick, Y Liu, ...
Nature methods 19 (12), 1599-1611, 2022
442022
Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region
B Gangadharan, MS Sunitha, S Mukherjee, RR Chowdhury, F Haque, ...
Proceedings of the National Academy of Sciences 114 (42), 11115-11120, 2017
382017
Whole genome sequence analysis of blood lipid levels in> 66,000 individuals
MS Selvaraj, X Li, Z Li, A Pampana, DY Zhang, J Park, S Aslibekyan, ...
Nature communications 13 (1), 5995, 2022
342022
Multiancestry genome-wide association study of aortic stenosis identifies multiple novel loci in the Million Veteran Program
AM Small, GM Peloso, J Linefsky, J Aragam, A Galloway, V Tanukonda, ...
Circulation 147 (12), 942-955, 2023
292023
The transcriptome enables the identification of candidate genes behind medicinal value of Drumstick tree (Moringa oleifera)
SN Pasha, KM Shafi, AG Joshi, I Meenakshi, K Harini, J Mahita, ...
Genomics 112 (1), 621-628, 2020
272020
Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes
G Hindy, P Dornbos, MD Chaffin, DJ Liu, M Wang, MS Selvaraj, D Zhang, ...
The American Journal of Human Genetics 109 (1), 81-96, 2022
262022
Polygenic prediction of preeclampsia and gestational hypertension
MC Honigberg, B Truong, RR Khan, B Xiao, L Bhatta, HMT Vy, ...
Nature medicine 29 (6), 1540-1549, 2023
232023
Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies
X Li, C Quick, H Zhou, SM Gaynor, Y Liu, H Chen, MS Selvaraj, R Sun, ...
Nature genetics 55 (1), 154-164, 2023
212023
Structural attributes for the recognition of weak and anomalous regions in coiled-coils of myosins and other motor proteins
MS Sunitha, AG Nair, A Charya, K Jadhav, S Mukhopadhyay, ...
BMC research notes 5, 1-16, 2012
162012
Myosinome: A database of myosins from select eukaryotic genomes to facilitate analysis of sequence-structure-function relationships
DP Syamaladevi, MS Sunitha, S Kalaimathy, CC Reddy, M Iftekhar, ...
Bioinformatics and Biology Insights 6, BBI. S9902, 2012
102012
Beyond the myosin mesa: A potential unifying hypothesis on the underlying molecular basis of hyper-contractility caused by a majority of hypertrophic cardiomyopathy mutations
S Nag, DV Trivedi, SS Sarkar, S Sutton, KM Ruppel, JA Spudich
bioRxiv, 065508, 2016
72016
Dataset for the combined transcriptome assembly of M. oleifera and functional annotation
KM Shafi, AG Joshi, I Meenakshi, SN Pasha, K Harini, J Mahita, ...
Data in Brief 30, 105416, 2020
52020
Identification and stratification of systemic lupus erythematosus patients into two transcriptionally distinct clusters based on IFN-I signature
V Shobha, A Mohan, AV Malini, P Chopra, P Karunanithi, ...
Lupus 30 (5), 762-774, 2021
42021
Integrative structural modelling of the cardiac thin filament: energetics at the interface and conservation patterns reveal a spotlight on period 2 of tropomyosin
SS Margaret, JA Mercer, JA Spudich, R Sowdhamini
Bioinformatics and Biology Insights 6, BBI. S9798, 2012
42012
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