Ben Kleinstiver
Ben Kleinstiver
Assistant Professor, Massachusetts General Hospital; Assistant Professor, Harvard Medical School
Verified email at - Homepage
Cited by
Cited by
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
BP Kleinstiver, V Pattanayak, MS Prew, SQ Tsai, NT Nguyen, Z Zheng, ...
Nature 529 (7587), 490-495, 2016
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
BP Kleinstiver, MS Prew, SQ Tsai, VV Topkar, NT Nguyen, Z Zheng, ...
Nature 523 (7561), 481-485, 2015
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
JS Chen, YS Dagdas, BP Kleinstiver, MM Welch, AA Sousa, ...
Nature 550 (7676), 407-410, 2017
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
BP Kleinstiver, MS Prew, SQ Tsai, NT Nguyen, VV Topkar, Z Zheng, ...
Nature Biotechnology, 2015
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
BP Kleinstiver, SQ Tsai, MS Prew, NT Nguyen, MM Welch, JM Lopez, ...
Nature Biotechnology 34 (8), 869-874, 2016
Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors
YE Tak, BP Kleinstiver, JK Nuñez, JY Hsu, JE Horng, J Gong, ...
nature methods 14 (12), 1163, 2017
Discovery of widespread type I and type V CRISPR-Cas inhibitors
ND Marino, JY Zhang, AL Borges, AA Sousa, LM Leon, BJ Rauch, ...
Science 362 (6411), 240-242, 2018
Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs
J Listgarten, M Weinstein, BP Kleinstiver, AA Sousa, JK Joung, J Crawford, ...
Nature biomedical engineering 2 (1), 38-47, 2018
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma
SK Saha, JD Gordan, BP Kleinstiver, P Vu, MS Najem, JC Yeo, L Shi, ...
Cancer discovery 6 (7), 727-739, 2016
Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing
BP Kleinstiver, AA Sousa, RT Walton, YE Tak, JY Hsu, K Clement, ...
Nature biotechnology 37 (3), 276-282, 2019
Monomeric site-specific nucleases for genome editing
BP Kleinstiver, JM Wolfs, T Kolaczyk, AK Roberts, SX Hu, DR Edgell
Proceedings of the National Academy of Sciences 109 (21), 8061-8066, 2012
Hypoxia drives transient site-specific copy gain and drug-resistant gene expression
JC Black, E Atabakhsh, J Kim, KM Biette, C Van Rechem, B Ladd, ...
Genes & development 29 (10), 1018-1031, 2015
Activities and specificities of CRISPR/Cas9 and Cas12a nucleases for targeted mutagenesis in maize
K Lee, Y Zhang, BP Kleinstiver, JA Guo, MJ Aryee, J Miller, A Malzahn, ...
Plant biotechnology journal 17 (2), 362-372, 2019
CRISPR/Cas9 Mediated Disruption of the SwedishAPP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease
B György, C Lööv, MP Zaborowski, S Takeda, BP Kleinstiver, C Commins, ...
Molecular Therapy-Nucleic Acids 11, 429-440, 2018
Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa
P Li, BP Kleinstiver, MY Leon, MS Prew, D Navarro-Gomez, ...
The CRISPR Journal 1 (1), 55-64, 2018
Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss
B György, C Nist-Lund, B Pan, Y Asai, KD Karavitaki, BP Kleinstiver, ...
Nature medicine 25 (7), 1123-1130, 2019
The I-TevI nuclease and linker domains contribute to the specificity of monomeric TALENs
BP Kleinstiver, L Wang, JM Wolfs, T Kolaczyk, B McDowell, X Wang, ...
G3: Genes, Genomes, Genetics 4 (6), 1155-1165, 2014
A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI
BP Kleinstiver, AD Fernandes, GB Gloor, DR Edgell
Nucleic acids research 38 (7), 2411-2427, 2010
Strand-specific contacts and divalent metal ion regulate double-strand break formation by the GIY-YIG homing endonuclease I-BmoI
JM Carter, NC Friedrich, B Kleinstiver, DR Edgell
Journal of molecular biology 374 (2), 306-321, 2007
High levels of AAV vector integration into CRISPR-induced DNA breaks
KS Hanlon, BP Kleinstiver, SP Garcia, MP Zaborowski, A Volak, SE Spirig, ...
Nature communications 10 (1), 1-11, 2019
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