| Precision tumor recognition by T cells with combinatorial antigen-sensing circuits KT Roybal, LJ Rupp, L Morsut, WJ Walker, KA McNally, JS Park, WA Lim Cell 164 (4), 770-779, 2016 | 928 | 2016 |
| Mania-like behavior induced by disruption of CLOCK K Roybal, D Theobold, A Graham, JA DiNieri, SJ Russo, V Krishnan, ... Proceedings of the National Academy of Sciences 104 (15), 6406-6411, 2007 | 914 | 2007 |
| Engineering customized cell sensing and response behaviors using synthetic notch receptors L Morsut, KT Roybal, X Xiong, RM Gordley, SM Coyle, M Thomson, ... Cell 164 (4), 780-791, 2016 | 842 | 2016 |
| Remote control of therapeutic T cells through a small molecule–gated chimeric receptor CY Wu, KT Roybal, EM Puchner, J Onuffer, WA Lim Science 350 (6258), aab4077, 2015 | 772 | 2015 |
| CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells LJ Rupp, K Schumann, KT Roybal, RE Gate, CJ Ye, WA Lim, A Marson Scientific reports 7 (1), 1-10, 2017 | 682 | 2017 |
| Engineering T cells with customized therapeutic response programs using synthetic notch receptors KT Roybal, JZ Williams, L Morsut, LJ Rupp, I Kolinko, JH Choe, ... Cell 167 (2), 419-432. e16, 2016 | 601 | 2016 |
| SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma JH Choe, PB Watchmaker, MS Simic, RD Gilbert, AW Li, NA Krasnow, ... Science translational medicine 13 (591), eabe7378, 2021 | 264 | 2021 |
| Pooled knockin targeting for genome engineering of cellular immunotherapies TL Roth, PJ Li, F Blaeschke, JF Nies, R Apathy, C Mowery, R Yu, ... Cell 181 (3), 728-744. e21, 2020 | 162 | 2020 |
| SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models A Hyrenius-Wittsten, Y Su, M Park, JM Garcia, J Alavi, N Perry, ... Science translational medicine 13 (591), eabd8836, 2021 | 126 | 2021 |
| Synthetic immunology: hacking immune cells to expand their therapeutic capabilities KT Roybal, WA Lim Annual review of immunology 35, 229-253, 2017 | 122 | 2017 |
| Clonal deletion of tumor-specific T cells by interferon-γ confers therapeutic resistance to combination immune checkpoint blockade CCS Pai, JT Huang, X Lu, DM Simons, C Park, A Chang, W Tamaki, E Liu, ... Immunity 50 (2), 477-492. e8, 2019 | 110 | 2019 |
| Precise T cell recognition programs designed by transcriptionally linking multiple receptors JZ Williams, GM Allen, D Shah, IS Sterin, KH Kim, VP Garcia, GE Shavey, ... Science 370 (6520), 1099-1104, 2020 | 102 | 2020 |
| Spatiotemporal patterning during T cell activation is highly diverse KL Singleton, KT Roybal, Y Sun, G Fu, NRJ Gascoigne, NSC Van Oers, ... Science signaling 2 (65), ra15-ra15, 2009 | 96 | 2009 |
| The CD3 ζ subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR–CD3 complex at the immunological synapse LM DeFord-Watts, DS Dougall, S Belkaya, BA Johnson, JL Eitson, ... The Journal of Immunology 186 (12), 6839-6847, 2011 | 92 | 2011 |
| Modular design of synthetic receptors for programmed gene regulation in cell therapies I Zhu, R Liu, JM Garcia, A Hyrenius-Wittsten, DI Piraner, J Alavi, DV Israni, ... Cell 185 (8), 1431-1443. e16, 2022 | 84 | 2022 |
| Synthetic cytokine circuits that drive T cells into immune-excluded tumors GM Allen, NW Frankel, NR Reddy, HK Bhargava, MA Yoshida, SR Stark, ... Science 378 (6625), eaba1624, 2022 | 68 | 2022 |
| DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation X Huang, JZ Williams, R Chang, Z Li, CE Burnett, R Hernandez-Lopez, ... Nature nanotechnology 16 (2), 214-223, 2021 | 68 | 2021 |
| Multidimensional control of therapeutic human cell function with synthetic gene circuits HS Li, DV Israni, KA Gagnon, KA Gan, MH Raymond, JD Sander, ... Science 378 (6625), 1227-1234, 2022 | 57 | 2022 |
| Differential regulation of the period genes in striatal regions following cocaine exposure E Falcon, A Ozburn, S Mukherjee, K Roybal, CA McClung PLoS One 8 (6), e66438, 2013 | 57 | 2013 |
| IFN-α suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells JP Huber, SR Gonzales-van Horn, KT Roybal, MA Gill, JD Farrar The Journal of Immunology 192 (12), 5687-5694, 2014 | 47 | 2014 |
