Role of organic anion-transporting polypeptides (OATPs) in cancer therapy N Thakkar, AC Lockhart, W Lee The AAPS journal 17, 535-545, 2015 | 112 | 2015 |
Effect of liver disease on hepatic transporter expression and function N Thakkar, JR Slizgi, KLR Brouwer Journal of pharmaceutical sciences 106 (9), 2282-2294, 2017 | 107 | 2017 |
A Cancer-Specific Variant of the SLCO1B3 Gene Encodes a Novel Human Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Localized Mainly in the … N Thakkar, K Kim, ER Jang, S Han, K Kim, D Kim, N Merchant, ... Molecular pharmaceutics 10 (1), 406-416, 2013 | 98 | 2013 |
Clinical pharmacology studies in critically ill children N Thakkar, S Salerno, CP Hornik, D Gonzalez Pharmaceutical research 34, 7-24, 2017 | 58 | 2017 |
Role of hypoxia inducible factor-1α in the regulation of the cancer-specific variant of organic anion transporting polypeptide 1B3 (OATP1B3), in colon and pancreatic cancer S Han, K Kim, N Thakkar, D Kim, W Lee Biochemical pharmacology 86 (6), 816-823, 2013 | 37 | 2013 |
The N-terminal region of organic anion transporting polypeptide 1B3 (OATP1B3) plays an essential role in regulating its plasma membrane trafficking SE Chun, N Thakkar, Y Oh, JE Park, S Han, G Ryoo, H Hahn, SH Maeng, ... Biochemical pharmacology 131, 98-105, 2017 | 24 | 2017 |
Differential expression of OATP1B3 mediates unconjugated testosterone influx TM Sissung, AM Ley, JD Strope, EM McCrea, S Beedie, CJ Peer, ... Molecular Cancer Research 15 (8), 1096-1105, 2017 | 21 | 2017 |
Population pharmacokinetics of tafenoquine, a novel antimalarial N Thakkar, JA Green, GCKW Koh, S Duparc, D Tenero, N Goyal Antimicrobial Agents and Chemotherapy 62 (11), 10.1128/aac. 00711-18, 2018 | 19 | 2018 |
Population pharmacokinetics/pharmacodynamics of 3, 4‐diaminopyridine free base in patients with Lambert‐Eaton myasthenia N Thakkar, JT Guptill, K Aleš, D Jacobus, L Jacobus, C Peloquin, ... CPT: Pharmacometrics & Systems Pharmacology 6 (9), 625-634, 2017 | 18 | 2017 |
An opportunistic study evaluating pharmacokinetics of sildenafil for the treatment of pulmonary hypertension in infants N Thakkar, D Gonzalez, M Cohen-Wolkowiez, MM Massaro, J Bernhardt, ... Journal of Perinatology, 2016 | 12 | 2016 |
Thymidylate synthase genotype-directed chemotherapy for patients with gastric and gastroesophageal junction cancers LW Goff, N Thakkar, L Du, E Chan, BR Tan, DB Cardin, HL McLeod, ... Plos one 9 (9), e107424, 2014 | 8 | 2014 |
Pharmacokinetics of temsavir, the active moiety of the HIV-1 attachment inhibitor prodrug, fostemsavir, coadministered with cobicistat, etravirine, darunavir/cobicistat, or … K Moore, N Thakkar, M Magee, H Sevinsky, B Vakkalagadda, S Lubin, ... Antimicrobial Agents and Chemotherapy 66 (4), e02251-21, 2022 | 7 | 2022 |
A phase I study of pegylated liposomal doxorubicin and temsirolimus in patients with refractory solid malignancies A Wang-Gillam, N Thakkar, AC Lockhart, K Williams, M Baggstrom, ... Cancer chemotherapy and pharmacology 74, 419-426, 2014 | 6 | 2014 |
Transporter-targeted Drug Delivery to the Retina S Hariharan, NR Thakkar, AK Mitra Retina Today 4, 57-62, 2009 | 5 | 2009 |
Molecular and Functional Investigation of Cancer-type and Liver-type Variants of Organic Anion Transporting Polypeptide 1B3 N Thakkar | 1 | 2015 |
Development of a physiologically based pharmacokinetic model of fostemsavir and its pivotal application to support dosing in pregnancy F Salem, D Nguyen, M Bush, KP Moore, J Mudunuru, K Stamatopoulos, ... CPT: Pharmacometrics & Systems Pharmacology, 2024 | | 2024 |
Survey of pharmaceutical industry's best practices around in vitro transporter assessment and Implications for Drug Development: Considerations from the IQ Transporter Working … HE Rollison, P Mitra, H Chanteux, Z Fang, X Liang, SH Park, C Costales, ... Drug Metabolism and Disposition, 2024 | | 2024 |
Model‐Based Dose Selection of Fostemsavir for Pediatric Populations With Multidrug‐Resistant HIV‐1 and Relative Bioavailability Assessment in Healthy Adults N Thakkar, M Magee, N Goyal, J Abberbock, C Jones, J Taylor, S Chabria, ... Clinical Pharmacology in Drug Development 12 (10), 991-1000, 2023 | | 2023 |
Model-based approach of dose selection and optimal pharmacokinetics sampling of fostemsavir for pediatric patients with multidrug resistant HIV-1 infection N Thakkar, M Magee, K Moore, P Ackerman, S Chabria, C Llamoso, ... JOURNAL OF THE INTERNATIONAL AIDS SOCIETY 23, 32-32, 2020 | | 2020 |
PK/PD MODELING AND SIMULATION OF 3, 4-DIAMINOPYRIDINE BASE IN PATIENTS WITH LAMBERT-EATON MYASTHENIA SYNDROME J Guptill, N Thakkar, C Peloquin, K Ales, D Jacobus, L Jacobus, ... MUSCLE & NERVE 54 (3), 528-528, 2016 | | 2016 |