Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors N Khan, M Jeffers, S Kumar, C Hackett, F Boldog, N Khramtsov, X Qian, ... Biochemical Journal 409 (2), 581-589, 2008 | 813 | 2008 |
Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101 JA Plumb, PW Finn, RJ Williams, MJ Bandara, MR Romero, CJ Watkins, ... Molecular cancer therapeutics 2 (8), 721-728, 2003 | 432 | 2003 |
Quantitative proteomic analysis of post-translational modifications of human histones HC Beck, EC Nielsen, R Matthiesen, LH Jensen, M Sehested, P Finn, ... Molecular & Cellular Proteomics 5 (7), 1314-1325, 2006 | 221 | 2006 |
Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo N Steele, P Finn, R Brown, JA Plumb British journal of cancer 100 (5), 758-763, 2009 | 176 | 2009 |
Pharmacophore discovery using the inductive logic programming system Progol P Finn, S Muggleton, D Page, A Srinivasan Machine Learning 30, 241-270, 1998 | 169 | 1998 |
Carbamic acid compounds comprising an amide linkage as HDAC inhibitors A Amolins, V Andrianov, RM Bokaldere, K Dikovska, JES Duffy, PW Finn, ... US Patent 7,880,020, 2011 | 113* | 2011 |
Carbamic acid compounds comprising an amide linkage as hdac inhibitors A Amolins, V Andrianov, RM Bokaldere, K Dikovska, JES Duffy, PW Finn, ... US Patent App. 12/983,971, 2011 | 105* | 2011 |
ElectroShape: fast molecular similarity calculations incorporating shape, chirality and electrostatics MS Armstrong, GM Morris, PW Finn, R Sharma, L Moretti, RI Cooper, ... Journal of computer-aided molecular design 24, 789-801, 2010 | 103 | 2010 |
Carbamic acid compounds comprising an amide linkage as HDAC inhibitors A Amolins, V Andrianov, RM Bokaldere, K Dikovska, JES Duffy, PW Finn, ... US Patent 7,569,724, 2009 | 103* | 2009 |
RAPID: Randomized pharmacophore identification for drug design PW Finn, LE Kavraki, JC Latombe, M R, C Shelton, ... Computational Geometry: Theory and Applications 4 (10), 263-272, 1998 | 95 | 1998 |
Rapid: Randomized pharmacophore identification for drug design PW Finn, LE Kavraki, JC Latombe, R Motwani, C Shelton, ... Proceedings of the thirteenth annual symposium on Computational geometry …, 1997 | 95 | 1997 |
Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors CJ Watkins, MR Romero-Martin, KG Moore, J Ritchie, PW Finn, I Kalvinsh, ... US Patent 6,888,027, 2005 | 94 | 2005 |
Ultrafast shape recognition: evaluating a new ligand-based virtual screening technology PJ Ballester, PW Finn, WG Richards Journal of Molecular Graphics and Modelling 27 (7), 836-845, 2009 | 93 | 2009 |
The cell cycle, chromatin and cancer: mechanism-based therapeutics come of age F McLaughlin, P Finn, NB La Thangue Drug discovery today 8 (17), 793-802, 2003 | 86 | 2003 |
Carbamic acid compounds comprising an ether linkage as HDAC inhibitors CJ Watkins, MR Romero-Martin, PW Finn, I Kalvinsh, E Loza, D Lolya, ... US Patent 6,960,685, 2005 | 83 | 2005 |
Carbamic acid compounds comprising an ether linkage as HDAC inhibitors RM Bokaldere, JES Duffy, PW Finn, CJ Harris, I Kalvinsh, D Lolya, E Loza, ... US Patent 6,960,685, 2005 | 83* | 2005 |
Computational approaches to drug design PW Finn, LE Kavraki Algorithmica 25, 347-371, 1999 | 79 | 1999 |
Carbamic acid compounds comprising an amide linkage as HDAC inhibitors CJ Watkins, MR Romero-Martin, KG Moore, J Ritchie, PW Finn, I Kalvinsh, ... US Patent 7,569,724, 2009 | 77 | 2009 |
Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors CJ Watkins, MR Romero-Martin, KG Moore, J Ritchie, PW Finn, I Kalvinsh, ... US Patent 6,888,027, 2005 | 74 | 2005 |
Carbamic acid compounds comprising an amide linkage as HDAC inhibitors CJ Watkins, MR Romero-Martin, KG Moore, J Ritchie, PW Finn, I Kalvinsh, ... US Patent 7,569,724, 2009 | 72 | 2009 |