| Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression IS Harris, AE Treloar, S Inoue, M Sasaki, C Gorrini, KC Lee, KY Yung, ... Cancer cell 27 (2), 211-222, 2015 | 915 | 2015 |
| The development of inflammatory TH-17 cells requires interferon-regulatory factor 4 A Brüstle, S Heink, M Huber, C Rosenplänter, C Stadelmann, P Yu, ... Nature immunology 8 (9), 958-966, 2007 | 887 | 2007 |
| IDH1 (R132H) mutation increases murine haematopoietic progenitors and alters epigenetics M Sasaki, CB Knobbe, JC Munger, EF Lind, D Brenner, A Brüstle, ... Nature 488 (7413), 656-659, 2012 | 603 | 2012 |
| Glutathione Primes T Cell Metabolism for Inflammation TW Mak, M Grusdat, GS Duncan, C Dostert, Y Nonnenmacher, M Cox, ... Immunity 46 (4), 675-689, 2017 | 440 | 2017 |
| Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity PA Lang, KS Lang, HC Xu, M Grusdat, IA Parish, M Recher, AR Elford, ... Proceedings of the National Academy of Sciences 109 (4), 1210-1215, 2012 | 365 | 2012 |
| IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype M Huber, A Brüstle, K Reinhard, A Guralnik, G Walter, A Mahiny, ... Proceedings of the National Academy of Sciences 105 (52), 20846-20851, 2008 | 359 | 2008 |
| A Th17‐like developmental process leads to CD8+ Tc17 cells with reduced cytotoxic activity M Huber, S Heink, H Grothe, A Guralnik, K Reinhard, K Elflein, T Hünig, ... European journal of immunology 39 (7), 1716-1725, 2009 | 322 | 2009 |
| IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis M Huber, S Heink, A Pagenstecher, K Reinhard, J Ritter, A Visekruna, ... The Journal of Clinical Investigation 123 (1), 247, 2013 | 307 | 2013 |
| IL-27 inhibits the development of regulatory T cells via STAT3 M Huber, V Steinwald, A Guralnik, A Brüstle, P Kleemann, ... International immunology 20 (2), 223-234, 2008 | 230 | 2008 |
| Lymphocyte-derived ACh regulates local innate but not adaptive immunity C Reardon, GS Duncan, A Brüstle, D Brenner, MW Tusche, P Olofsson, ... Proceedings of the National Academy of Sciences 110 (4), 1410-1415, 2013 | 220 | 2013 |
| Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation N Bollig, A Brüstle, K Kellner, W Ackermann, E Abass, H Raifer, B Camara, ... Proceedings of the National Academy of Sciences 109 (22), 8664-8669, 2012 | 217 | 2012 |
| The transcription factor IFN regulatory factor–4 controls experimental colitis in mice via T cell–derived IL-6 J Mudter, L Amoussina, M Schenk, J Yu, A Brüstle, B Weigmann, R Atreya, ... The Journal of clinical investigation 118 (7), 2415-2426, 2008 | 143 | 2008 |
| Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation F Bornancin, F Renner, R Touil, H Sic, Y Kolb, I Touil-Allaoui, JS Rush, ... The Journal of Immunology 194 (8), 3723-3734, 2015 | 137 | 2015 |
| The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells A Brüstle, D Brenner, CB Knobbe, PA Lang, C Virtanen, BM Hershenfield, ... The Journal of clinical investigation 122 (12), 4698-4709, 2012 | 137 | 2012 |
| Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation C Reardon, M Lechmann, A Brüstle, MG Gareau, N Shuman, D Philpott, ... Immunity 35 (2), 223-235, 2011 | 130 | 2011 |
| The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk E Arpaia, H Blaser, M Quintela-Fandino, G Duncan, HS Leong, A Ablack, ... Oncogene 31 (7), 884-896, 2012 | 129 | 2012 |
| IRF4 regulates IL‐17A promoter activity and controls RORγt‐dependent Th17 colitis in vivo J Mudter, J Yu, C Zufferey, A Brüstle, S Wirtz, B Weigmann, A Hoffman, ... Inflammatory bowel diseases 17 (6), 1343-1358, 2011 | 123 | 2011 |
| IL-17-producing γδ T cells switch migratory patterns between resting and activated states DR McKenzie, EE Kara, CR Bastow, TS Tyllis, KA Fenix, CE Gregor, ... Nature Communications 8 (1), 15632, 2017 | 117 | 2017 |
| Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 IA Parish, HD Marshall, MM Staron, PA Lang, A Brüstle, JH Chen, W Cui, ... The Journal of clinical investigation 124 (8), 3455-3468, 2014 | 108 | 2014 |
| TAp73 is required for spermatogenesis and the maintenance of male fertility S Inoue, R Tomasini, A Rufini, AJ Elia, M Agostini, I Amelio, D Cescon, ... Proceedings of the National Academy of Sciences 111 (5), 1843-1848, 2014 | 100 | 2014 |
Dirk BrennerProfessor of Immunology & Genetics, Luxembourg Institute of Health (LIH) & University of LuxembourgVerified email at lih.lu
