|CpG island methylator phenotype in colorectal cancer|
M Toyota, N Ahuja, M Ohe-Toyota, JG Herman, SB Baylin, JPJ Issa
Proceedings of the National Academy of Sciences 96 (15), 8681-8686, 1999
|Alterations in DNA methylation: a fundamental aspect of neoplasia|
SB Baylln, JG Herman, JR Graff, PM Vertino, JP Issa
Advances in cancer research 72, 141-196, 1997
|Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma|
JG Herman, A Umar, K Polyak, JR Graff, N Ahuja, JPJ Issa, S Markowitz, ...
Proceedings of the National Academy of Sciences 95 (12), 6870-6875, 1998
|Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers|
JG Herman, A Merlo, LI Mao, RG Lapidus, JPJ Issa, NE Davidson, ...
Cancer research 55 (20), 4525-4530, 1995
|Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study|
H Kantarjian, JPJ Issa, CS Rosenfeld, JM Bennett, M Albitar, J DiPersio, ...
Cancer: Interdisciplinary International Journal of the American Cancerá…, 2006
|Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon|
JPJ Issa, YL Ottaviano, P Celano, SR Hamilton, NE Davidson, SB Baylin
Nature genetics 7 (4), 536-540, 1994
|CpG island methylator phenotype in cancer|
Nature Reviews Cancer 4 (12), 988-993, 2004
|A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements|
AS Yang, MRH EstÚcio, K Doshi, Y Kondo, EH Tajara, JPJ Issa
Nucleic acids research 32 (3), e38-e38, 2004
|Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies|
JPJ Issa, G Garcia-Manero, FJ Giles, R Mannari, D Thomas, S Faderl, ...
Blood 103 (5), 1635-1640, 2004
|Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia|
H Kantarjian, Y Oki, G Garcia-Manero, X Huang, S O'Brien, J Cortes, ...
Blood 109 (1), 52-57, 2007
|Dnmt3a is essential for hematopoietic stem cell differentiation|
GA Challen, D Sun, M Jeong, M Luo, J Jelinek, JS Berg, C Bock, ...
Nature genetics 44 (1), 23, 2012
|Aging and DNA methylation in colorectal mucosa and cancer|
N Ahuja, Q Li, AL Mohan, SB Baylin, JPJ Issa
Cancer research 58 (23), 5489-5494, 1998
|Accelerated age-related CpG island methylation in ulcerative colitis|
JPJ Issa, N Ahuja, M Toyota, MP Bronner, TA Brentnall
Cancer research 61 (9), 3573-3577, 2001
|Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation|
Y Kondo, L Shen, AS Cheng, S Ahmed, Y Boumber, C Charo, T Yamochi, ...
Nature genetics 40 (6), 741, 2008
|Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis|
M Esteller, M Toyota, M Sanchez-Cespedes, G Capella, MA Peinado, ...
Cancer research 60 (9), 2368-2371, 2000
|Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification|
M Toyota, C Ho, N Ahuja, KW Jair, Q Li, M Ohe-Toyota, SB Baylin, ...
Cancer research 59 (10), 2307-2312, 1999
|Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype|
M Toyota, N Ahuja, H Suzuki, F Itoh, M Ohe-Toyota, K Imai, SB Baylin, ...
Cancer research 59 (21), 5438-5442, 1999
|Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer|
L Shen, M Toyota, Y Kondo, E Lin, L Zhang, Y Guo, NS Hernandez, ...
Proceedings of the National Academy of Sciences 104 (47), 18654-18659, 2007
|Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells|
YL Ottaviano, JP Issa, FF Parl, HS Smith, SB Baylin, NE Davidson
Cancer research 54 (10), 2552-2555, 1994
|Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia|
G Garcia-Manero, HM Kantarjian, B Sanchez-Gonzalez, H Yang, ...
Blood 108 (10), 3271-3279, 2006