Jean-Pierre Issa
Jean-Pierre Issa
Coriell Institute for Medical Research
Verified email at coriell.org - Homepage
TitleCited byYear
CpG island methylator phenotype in colorectal cancer
M Toyota, N Ahuja, M Ohe-Toyota, JG Herman, SB Baylin, JPJ Issa
Proceedings of the National Academy of Sciences 96 (15), 8681-8686, 1999
25231999
Alterations in DNA methylation: a fundamental aspect of neoplasia
SB Baylln, JG Herman, JR Graff, PM Vertino, JP Issa
Advances in cancer research 72, 141-196, 1997
23771997
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
JG Herman, A Umar, K Polyak, JR Graff, N Ahuja, JPJ Issa, S Markowitz, ...
Proceedings of the National Academy of Sciences 95 (12), 6870-6875, 1998
21061998
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
JG Herman, A Merlo, LI Mao, RG Lapidus, JPJ Issa, NE Davidson, ...
Cancer research 55 (20), 4525-4530, 1995
17651995
Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
H Kantarjian, JPJ Issa, CS Rosenfeld, JM Bennett, M Albitar, J DiPersio, ...
Cancer: Interdisciplinary International Journal of the American Cancer …, 2006
14602006
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
JPJ Issa, YL Ottaviano, P Celano, SR Hamilton, NE Davidson, SB Baylin
Nature genetics 7 (4), 536-540, 1994
12821994
CpG island methylator phenotype in cancer
JP Issa
Nature Reviews Cancer 4 (12), 988-993, 2004
11272004
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
AS Yang, MRH Estécio, K Doshi, Y Kondo, EH Tajara, JPJ Issa
Nucleic acids research 32 (3), e38-e38, 2004
9312004
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
JPJ Issa, G Garcia-Manero, FJ Giles, R Mannari, D Thomas, S Faderl, ...
Blood 103 (5), 1635-1640, 2004
8552004
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
H Kantarjian, Y Oki, G Garcia-Manero, X Huang, S O'Brien, J Cortes, ...
Blood 109 (1), 52-57, 2007
8022007
Dnmt3a is essential for hematopoietic stem cell differentiation
GA Challen, D Sun, M Jeong, M Luo, J Jelinek, JS Berg, C Bock, ...
Nature genetics 44 (1), 23, 2012
7662012
Aging and DNA methylation in colorectal mucosa and cancer
N Ahuja, Q Li, AL Mohan, SB Baylin, JPJ Issa
Cancer research 58 (23), 5489-5494, 1998
6791998
Accelerated age-related CpG island methylation in ulcerative colitis
JPJ Issa, N Ahuja, M Toyota, MP Bronner, TA Brentnall
Cancer research 61 (9), 3573-3577, 2001
6612001
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
Y Kondo, L Shen, AS Cheng, S Ahmed, Y Boumber, C Charo, T Yamochi, ...
Nature genetics 40 (6), 741, 2008
6202008
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis
M Esteller, M Toyota, M Sanchez-Cespedes, G Capella, MA Peinado, ...
Cancer research 60 (9), 2368-2371, 2000
6092000
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification
M Toyota, C Ho, N Ahuja, KW Jair, Q Li, M Ohe-Toyota, SB Baylin, ...
Cancer research 59 (10), 2307-2312, 1999
5961999
Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
M Toyota, N Ahuja, H Suzuki, F Itoh, M Ohe-Toyota, K Imai, SB Baylin, ...
Cancer research 59 (21), 5438-5442, 1999
5931999
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
L Shen, M Toyota, Y Kondo, E Lin, L Zhang, Y Guo, NS Hernandez, ...
Proceedings of the National Academy of Sciences 104 (47), 18654-18659, 2007
5772007
Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells
YL Ottaviano, JP Issa, FF Parl, HS Smith, SB Baylin, NE Davidson
Cancer research 54 (10), 2552-2555, 1994
5641994
Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia
G Garcia-Manero, HM Kantarjian, B Sanchez-Gonzalez, H Yang, ...
Blood 108 (10), 3271-3279, 2006
5432006
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