Paul B. Yu
Paul B. Yu
Harvard Medical School, Brigham and Women’s Hospital
Verified email at
TitleCited byYear
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
BY Paul, CC Hong, C Sachidanandan, JL Babitt, DY Deng, SA Hoyng, ...
Nature chemical biology 4 (1), 33, 2008
BMP type I receptor inhibition reduces heterotopic ossification
BY Paul, DY Deng, CS Lai, CC Hong, GD Cuny, ML Bouxsein, DW Hong, ...
Nature medicine 14 (12), 1363, 2008
Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
GD Cuny, BY Paul, JK Laha, X Xing, JF Liu, CS Lai, DY Deng, ...
Bioorganic & medicinal chemistry letters 18 (15), 4388-4392, 2008
Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells
J Hao, MA Daleo, CK Murphy, BY Paul, JN Ho, J Hu, RT Peterson, ...
PloS one 3 (8), e2904, 2008
BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
H Beppu, F Ichinose, N Kawai, RC Jones, PB Yu, WM Zapol, K Miyazono, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 287 (6 …, 2004
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
L Long, ML Ormiston, X Yang, M Southwood, S Gräf, RD Machado, ...
Nature medicine 21 (7), 777, 2015
Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells.
PB Yu, H Beppu, N Kawai, E Li, KD Bloch
The Journal of biological chemistry 280 (26), 24443-24450, 2005
ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A
SJ Hatsell, V Idone, DMA Wolken, L Huang, HJ Kim, L Wang, X Wen, ...
Science translational medicine 7 (303), 303ra137-303ra137, 2015
Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis
M Derwall, R Malhotra, CS Lai, Y Beppu, E Aikawa, JS Seehra, WM Zapol, ...
Arteriosclerosis, thrombosis, and vascular biology 32 (3), 613-622, 2012
Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts
N Kamiya, T Kobayashi, Y Mochida, PB Yu, M Yamauchi, HM Kronenberg, ...
Journal of Bone and Mineral Research 25 (2), 200-210, 2010
Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice
AU Steinbicker, TB Bartnikas, LK Lohmeyer, P Leyton, C Mayeur, SM Kao, ...
Blood 118 (15), 4224-4230, 2011
Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation
AU Steinbicker, C Sachidanandan, AJ Vonner, RZ Yusuf, DY Deng, ...
Blood 117 (18), 4915-4923, 2011
Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva
T Fukuda, M Kohda, K Kanomata, J Nojima, A Nakamura, J Kamizono, ...
Journal of Biological Chemistry 284 (11), 7149-7156, 2009
Transforming growth factor β can stimulate Smad1 phosphorylation independently of bone morphogenic protein receptors
KH Wrighton, X Lin, BY Paul, XH Feng
Journal of Biological Chemistry 284 (15), 9755-9763, 2009
A new class of small molecule inhibitor of BMP signaling
CE Sanvitale, G Kerr, A Chaikuad, MC Ramel, AH Mohedas, S Reichert, ...
PloS one 8 (4), e62721, 2013
Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells
JH Boergermann, J Kopf, PB Yu, P Knaus
The international journal of biochemistry & cell biology 42 (11), 1802-1807, 2010
Applications of small molecule BMP inhibitors in physiology and disease
CC Hong, BY Paul
Cytokine & growth factor reviews 20 (5-6), 409-418, 2009
Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4
Y Xia, BY Paul, Y Sidis, H Beppu, KD Bloch, AL Schneyer, HY Lin
Journal of Biological Chemistry 282 (25), 18129-18140, 2007
Brief report: chimeric pigs produced from induced pluripotent stem cells demonstrate germline transmission and no evidence of tumor formation in young pigs
FD West, EW Uhl, Y Liu, H Stowe, Y Lu, P Yu, A Gallegos‐Cardenas, ...
Stem cells 29 (10), 1640-1643, 2011
Modulation of natural IgM binding and complement activation by natural IgG antibodies: a role for IgG anti-Gal alpha1-3Gal antibodies.
PB Yu, ZE Holzknecht, D Bruno, W Parker, JL Platt
The Journal of Immunology 157 (11), 5163-5168, 1996
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