Sajid Khan
Sajid Khan
Assistant Professor/Research at the University of Texas Health Science Center San Antonio
Verified email at
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A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
S Khan, X Zhang, D Lv, Q Zhang, Y He, P Zhang, X Liu, D Thummuri, ...
Nature medicine 25 (12), 1938-1947, 2019
Role of adipokines and cytokines in obesity-associated breast cancer: therapeutic targets
S Khan, S Shukla, S Sinha, SM Meeran
Cytokine & growth factor reviews 24 (6), 503-513, 2013
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
Y He, X Zhang, J Chang, HN Kim, P Zhang, Y Wang, S Khan, X Liu, ...
Nature communications 11 (1), 1996, 2020
PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics
S Khan, Y He, X Zhang, Y Yuan, S Pu, Q Kong, G Zheng, D Zhou
Oncogene 39 (26), 4909-4924, 2020
Synthesis of β-Carboline-Based N-Heterocyclic Carbenes and Their Antiproliferative and Antimetastatic Activities against Human Breast Cancer Cells
SU Dighe, S Khan, I Soni, P Jain, S Shukla, R Yadav, P Sen, SM Meeran, ...
Journal of Medicinal Chemistry 58 (8), 3485-3499, 2015
Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis
S Shukla, S Sinha, S Khan, S Kumar, K Singh, K Mitra, R Maurya, ...
Scientific reports 6 (1), 1-17, 2016
Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity
X Zhang, D Thummuri, X Liu, W Hu, P Zhang, S Khan, Y Yuan, D Zhou, ...
European journal of medicinal chemistry 192, 112186, 2020
Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis
S Sinha, S Khan, S Shukla, AD Lakra, S Kumar, G Das, R Maurya, ...
The international journal of biochemistry & cell biology 77, 41-56, 2016
DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas
Y He, R Koch, V Budamagunta, P Zhang, X Zhang, S Khan, D Thummuri, ...
Journal of hematology & oncology 13 (1), 1-13, 2020
Cucurbitacin B alters the expression of tumor-related genes by epigenetic modifications in NSCLC and inhibits NNK-induced lung tumorigenesis
S Shukla, S Khan, S Kumar, S Sinha, M Farhan, HK Bora, R Maurya, ...
Cancer prevention research 8 (6), 552-562, 2015
Centchroman suppresses breast cancer metastasis by reversing epithelial–mesenchymal transition via downregulation of HER2/ERK1/2/MMP-9 signaling
S Khan, S Shukla, S Sinha, AD Lakra, HK Bora, SM Meeran
The International Journal of Biochemistry & Cell Biology 58, 1-16, 2015
Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies
Y He, S Khan, Z Huo, D Lv, X Zhang, X Liu, Y Yuan, R Hromas, M Xu, ...
Journal of hematology & oncology 13 (1), 1-24, 2020
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity
D Lv, P Pal, X Liu, Y Jia, D Thummuri, P Zhang, W Hu, J Pei, Q Zhang, ...
Nature communications 12 (1), 6896, 2021
Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells
S Sinha, S Shukla, S Khan, TO Tollefsbol, SM Meeran
Molecular and cellular endocrinology 406, 102-114, 2015
Inhibition of Inositol 1, 4, 5‐Trisphosphate Receptor Induce Breast Cancer Cell Death Through Deregulated Autophagy and Cellular Bioenergetics
A Singh, M Chagtoo, S Tiwari, N George, B Chakravarti, S Khan, ...
Journal of cellular biochemistry 118 (8), 2333-2346, 2017
Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
R Kolb, U De, S Khan, Y Luo, MC Kim, H Yu, C Wu, J Mo, X Zhang, ...
Nature communications 12 (1), 1281, 2021
Epigenetic targets in cancer and aging: dietary and therapeutic interventions
S Khan, S Shukla, S Sinha, SM Meeran
Expert opinion on therapeutic targets 20 (6), 689-703, 2016
Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition
P Pal, D Thummuri, D Lv, X Liu, P Zhang, W Hu, SK Poddar, N Hua, ...
Journal of Medicinal Chemistry 64 (19), 14230-14246, 2021
Centchroman prevents metastatic colonization of breast cancer cells and disrupts angiogenesis via inhibition of RAC1/PAK1/β-catenin signaling axis
S Khan, S Shukla, M Farhan, S Sinha, AD Lakra, D Penta, A Kannan, ...
Life Sciences 256, 117976, 2020
Telomeric repeat containing RNA (TERRA): aging and cancer
S Sinha, S Shukla, S Khan, M Farhan, MA Kamal, S Musthapa Meeran
CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS …, 2015
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