Liam Keegan
Liam Keegan
Central European Institute of Technology (CEITEC), Masaryk University Brno, Czech Republic
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Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein
L Keegan, G Gill, M Ptashne
Science 231 (4739), 699-704, 1986
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature
GI Rice, PR Kasher, GMA Forte, NM Mannion, SM Greenwood, ...
Nature genetics 44 (11), 1243-1248, 2012
The RNA-editing enzyme ADAR1 controls innate immune responses to RNA
NM Mannion, SM Greenwood, R Young, S Cox, J Brindle, D Read, ...
Cell reports 9 (4), 1482-1494, 2014
Dynamic landscape and regulation of RNA editing in mammals
MH Tan, Q Li, R Shanmugam, R Piskol, J Kohler, AN Young, KI Liu, ...
Nature 550 (7675), 249-254, 2017
A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity
MJ Palladino, LP Keegan, MA O'Connell, RA Reenan
Cell 102 (4), 437-449, 2000
Identifying RNA editing sites using RNA sequencing data alone
G Ramaswami, R Zhang, R Piskol, LP Keegan, P Deng, MA O'connell, ...
Nature methods 10 (2), 128-132, 2013
Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization.
PA Silver, LP Keegan, M Ptashine
Proceedings of the National Academy of Sciences 81 (19), 5951-5955, 1984
The many roles of an RNA editor
LP Keegan, A Gallo, MA O'Connell
Nature Reviews Genetics 2 (11), 869-878, 2001
Dynamic association of RNA-editing enzymes with the nucleolus
JMP Desterro, LP Keegan, M Lafarga, MT Berciano, M O'Connell, ...
Journal of cell science 116 (9), 1805-1818, 2003
dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing
MJ Palladino, LP Keegan, MA O'CONNELL, RA Reenan
Rna 6 (7), 1004-1018, 2000
Editing independent effects of ADARs on the miRNA/siRNA pathways
BSE Heale, LP Keegan, L McGurk, G Michlewski, J Brindle, CM Stanton, ...
The EMBO journal 28 (20), 3145-3156, 2009
Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes
LP Keegan, A Leroy, D Sproul, MA O'Connell
Genome biology 5, 1-10, 2004
Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects
R Marcucci, J Brindle, S Paro, A Casadio, S Hempel, N Morrice, A Bisso, ...
The EMBO journal 30 (20), 4211-4222, 2011
An ADAR that edits transcripts encoding ion channel subunits functions as a dimer
A Gallo, LP Keegan, GM Ring, MA O'Connell
The EMBO journal 22 (13), 3421-3430, 2003
SUMO-1 modification alters ADAR1 editing activity
JMP Desterro, LP Keegan, E Jaffray, RT Hay, MA O'Connell, ...
Molecular biology of the cell 16 (11), 5115-5126, 2005
ADAR RNA editing in human disease; more to it than meets the I
A Gallo, D Vukic, D Michalík, MA O’connell, LP Keegan
Human genetics 136, 1265-1278, 2017
RNA editing by mammalian ADARs
M Hogg, S Paro, LP Keegan, MA O'Connell
Advances in genetics 73, 87-120, 2011
Tuning of RNA editing by ADAR is required in Drosophila
LP Keegan, J Brindle, A Gallo, A Leroy, RA Reenan, MA O'Connell
The EMBO journal 24 (12), 2183-2193, 2005
Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
LP Keegan, L McGurk, JP Palavicini, J Brindle, S Paro, X Li, ...
Nucleic acids research 39 (16), 7249-7262, 2011
ADAR RNA modifications, the epitranscriptome and innate immunity
J Quin, J Sedmík, D Vukić, A Khan, LP Keegan, MA O’Connell
Trends in biochemical sciences 46 (9), 758-771, 2021
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