David C Wedge

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Ludmil B. AlexandrovAssociate Professor, University of California San DiegoVerified email at ucsd.edu
Peter CampbellWellcome Sanger InstituteVerified email at sanger.ac.uk
Inigo MartincorenaWellcome Sanger InstituteVerified email at sanger.ac.uk
Moritz GerstungDivision Head, German Cancer Research Centre DKFZVerified email at dkfz.de
Douglas KellUniversity of LiverpoolVerified email at liv.ac.uk
Niccolo BolliUniversity of MilanVerified email at unimi.it
Roy GoodacreDepartment of Biochemistry and Systems Biology, ISMIB, University of LiverpoolVerified email at liverpool.ac.uk
Rebecca FitzgeraldProfessor of Cancer Prevention, Cambridge UniversityVerified email at cam.ac.uk
Sam BehjatiVerified email at sanger.ac.uk
Dan J WoodcockUniversity of OxfordVerified email at well.ox.ac.uk
Naser Ansari-PourSenior Scientist in Cancer Genomics/ Member of Congregation/ DPhil Supervisor University of OxfordVerified email at ndorms.ox.ac.uk
Daniel Simon BrewerProfessor of Medical Bioinformatics and Genomics, Norwich Medical School, University of East AngliaVerified email at uea.ac.uk
Tongwu ZhangEarl Stadtman Investigator, National Cancer Institute, National Institutes of HealthVerified email at mail.nih.gov
Stefan C DentroDKFZVerified email at sanger.ac.uk
Máire Ní LeathlobhairSchool of Genetics and Microbiology, Trinity College DublinVerified email at tcd.ie
Andreas J. GruberUniversity of KonstanzVerified email at uni-konstanz.de
G Maria JakobsdottirUniversity of ManchesterVerified email at manchester.ac.uk
Avraam TapinosThe University of ManchesterVerified email at manchester.ac.uk
Christopher WirthUniversity of ManchesterVerified email at manchester.ac.uk
Aliah HawariComputational Biologist, University of ManchesterVerified email at manchester.ac.uk

David C Wedge

Professor of Cancer Genomics and Data Science, University of Manchester

Verified email at manchester.ac.uk - Homepage

Cancer Genomics Cancer Evolution Data Science Multiomics Equality Diversity and Inclusion


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Signatures of mutational processes in human cancer LB Alexandrov, S Nik-Zainal, DC Wedge, SAJR Aparicio, S Behjati, ... Nature 500 (7463), 415-421, 2013	9828	2013
Landscape of somatic mutations in 560 breast cancer whole-genome sequences S Nik-Zainal, H Davies, J Staaf, M Ramakrishna, D Glodzik, X Zou, ... Nature 534 (7605), 47-54, 2016	2160	2016
Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2 J Nangalia, CE Massie, EJ Baxter, FL Nice, G Gundem, DC Wedge, ... New England Journal of Medicine 369 (25), 2391-2405, 2013	2117	2013
Mutational processes molding the genomes of 21 breast cancers S Nik-Zainal, LB Alexandrov, DC Wedge, P Van Loo, CD Greenman, ... Cell 149 (5), 979-993, 2012	2054	2012
Clinical and biological implications of driver mutations in myelodysplastic syndromes E Papaemmanuil, M Gerstung, L Malcovati, S Tauro, G Gundem, ... Blood, The Journal of the American Society of Hematology 122 (22), 3616-3627, 2013	1978	2013
The landscape of cancer genes and mutational processes in breast cancer PJ Stephens, PS Tarpey, H Davies, P Van Loo, C Greenman, DC Wedge, ... Nature 486 (7403), 400-404, 2012	1972	2012
High burden and pervasive positive selection of somatic mutations in normal human skin I Martincorena, A Roshan, M Gerstung, P Ellis, P Van Loo, S McLaren, ... Science 348 (6237), 880-886, 2015	1697	2015
Pan-cancer analysis of whole genomes Nature 578 (7793), 82-93, 2020	1650*	2020
The life history of 21 breast cancers S Nik-Zainal, P Van Loo, DC Wedge, LB Alexandrov, CD Greenman, ... Cell 149 (5), 994-1007, 2012	1545	2012
The evolutionary history of lethal metastatic prostate cancer G Gundem, P Van Loo, B Kremeyer, LB Alexandrov, JMC Tubio, ... Nature 520 (7547), 353-357, 2015	1426	2015
Deciphering signatures of mutational processes operative in human cancer LB Alexandrov, S Nik-Zainal, DC Wedge, PJ Campbell, MR Stratton Cell reports 3 (1), 246-259, 2013	1245	2013
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution EC De Bruin, N McGranahan, R Mitter, M Salm, DC Wedge, L Yates, ... Science 346 (6206), 251-256, 2014	1237	2014
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing J Zhang, J Fujimoto, J Zhang, DC Wedge, X Song, J Zhang, S Seth, ... Science 346 (6206), 256-259, 2014	1012	2014
Clock-like mutational processes in human somatic cells LB Alexandrov, PH Jones, DC Wedge, JE Sale, PJ Campbell, ... Nature genetics 47 (12), 1402-1407, 2015	972	2015
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma N Bolli, H Avet-Loiseau, DC Wedge, P Van Loo, LB Alexandrov, ... Nature communications 5 (1), 2997, 2014	948	2014
The evolutionary history of 2,658 cancers M Gerstung, C Jolly, I Leshchiner, SC Dentro, S Gonzalez, D Rosebrock, ... Nature 578 (7793), 122-128, 2020	849	2020
Subclonal diversification of primary breast cancer revealed by multiregion sequencing LR Yates, M Gerstung, S Knappskog, C Desmedt, G Gundem, P Van Loo, ... Nature medicine 21 (7), 751-759, 2015	834	2015
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone S Behjati, PS Tarpey, N Presneau, S Scheipl, N Pillay, P Van Loo, ... Nature genetics 45 (12), 1479-1482, 2013	780	2013
Genomic evolution of breast cancer metastasis and relapse LR Yates, S Knappskog, D Wedge, JHR Farmery, S Gonzalez, ... Cancer cell 32 (2), 169-184. e7, 2017	648	2017
Effect of mutation order on myeloproliferative neoplasms CA Ortmann, DG Kent, J Nangalia, Y Silber, DC Wedge, J Grinfeld, ... New England Journal of Medicine 372 (7), 601-612, 2015	589	2015

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