| Evaluation of 2 ‘-modified oligonucleotides containing 2 ‘-deoxy gaps as antisense inhibitors of gene expression BP Monia, EA Lesnik, C Gonzalez, WF Lima, D McGee, CJ Guinosso, ... Journal of Biological Chemistry 268 (19), 14514-14522, 1993 | 1023 | 1993 |
| Sugar modified oligonucleotides that detect and modulate gene expression PD Cook, AM Kawasaki US Patent 5,670,633, 1997 | 872 | 1997 |
| Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets AM Kawasaki, MD Casper, SM Freier, EA Lesnik, MC Zounes, ... Journal of medicinal chemistry 36 (7), 831-841, 1993 | 606 | 1993 |
| 2'-modified oligonucleotides PD Cook, AM Kawasaki US Patent 6,005,087, 1999 | 334 | 1999 |
| Oligodeoxynucleotides containing 2'-O-modified adenosine: synthesis and effects on stability of DNA: RNA duplexes EA Lesnik, CJ Guinosso, AM Kawasaki, H Sasmor, M Zounes, ... Biochemistry 32 (30), 7832-7838, 1993 | 288 | 1993 |
| 2'-modified oligonucleotides PD Cook, AM Kawasaki US Patent 5,859,221, 1999 | 253 | 1999 |
| 2'modified oligonucleotides PD Cook, AM Kawasaki US Patent 6,531,584, 2003 | 250 | 2003 |
| 2'-O-acetamido modified monomers and oligomers M Manoharan, AM Kawasaki, PD Cook, AS Fraser, TP Prakash US Patent 6,147,200, 2000 | 242 | 2000 |
| Aminooxy-modified oligonucleotides and methods for making same M Manoharan, PD Cook, TP Prakash, AM Kawasaki US Patent 6,172,209, 2001 | 166 | 2001 |
| 2'-O-aminooxy-modified oligonucleotides PD Cook, M Manoharan, AM Kawasaki US Patent 6,127,533, 2000 | 164 | 2000 |
| Compound for detecting and modulating RNA activity and gene expression PD Cook, DJ Ecker, CJ Guinosso, OL Acevedo, A Kawasaki, ... US Patent 6,262,241, 2001 | 128 | 2001 |
| Sugar modified oligonucleotides that detect and modulate gene expression PD Cook, AM Kawasaki US Patent 6,307,040, 2001 | 126 | 2001 |
| 2'-O-modified oligonucleotides PD Cook, AM Kawasaki US Patent 5,872,232, 1999 | 121 | 1999 |
| Compositions for inhibiting RNA activity PD Cook, T Bruice, CJ Guinosso, AM Kawasaki US Patent 5,514,786, 1996 | 89 | 1996 |
| Sugar modified oligonucleotides PD Cook, AM Kawasaki US Patent 7,138,517, 2006 | 88 | 2006 |
| Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom M Manoharan, PD Cook, TP Prakash, AM Kawasaki US Patent 6,639,062, 2003 | 80 | 2003 |
| Compositions and methods for modulating RNA PD Cook, T Bruice, CJ Guinosso, AM Kawasaki, R Griffey US Patent 6,358,931, 2002 | 67 | 2002 |
| Regioselective synthesis of 2′-O-modified nucleosides AM Kawasaki, AS Fraser, M Manoharan, PD Cook, TP Prakash US Patent 6,403,779, 2002 | 64 | 2002 |
| Comparing In Vitro and In Vivo Activity of 2′-O-[2-(Methylamino)-2-oxoethyl]- and 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides TP Prakash, AM Kawasaki, EV Wancewicz, L Shen, BP Monia, BS Ross, ... Journal of medicinal chemistry 51 (9), 2766-2776, 2008 | 63 | 2008 |
| 2‘-O-[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analogue of 2‘-O-[2-(Methoxy)-ethyl]-Modified Oligonucleotide with Improved Protein Binding Properties … TP Prakash, M Manoharan, AM Kawasaki, AS Fraser, EA Lesnik, N Sioufi, ... Biochemistry 41 (39), 11642-11648, 2002 | 61 | 2002 |
