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Jessica L. Thomaston
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Packing of apolar side chains enables accurate design of highly stable membrane proteins
M Mravic, JL Thomaston, M Tucker, PE Solomon, L Liu, WF DeGrado
Science 363 (6434), 1418-1423, 2019
1082019
Inhibitors of the M2 proton channel engage and disrupt transmembrane networks of hydrogen-bonded waters
JL Thomaston, NF Polizzi, A Konstantinidi, J Wang, A Kolocouris, ...
Journal of the American Chemical Society 140 (45), 15219-15226, 2018
1082018
High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction
JL Thomaston, M Alfonso-Prieto, RA Woldeyes, JS Fraser, ML Klein, ...
Proceedings of the National Academy of Sciences 112 (46), 14260-14265, 2015
1052015
XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction
JL Thomaston, RA Woldeyes, T Nakane, A Yamashita, T Tanaka, ...
Proceedings of the National Academy of Sciences 114 (51), 13357-13362, 2017
752017
High-density grids for efficient data collection from multiple crystals
EL Baxter, L Aguila, R Alonso-Mori, CO Barnes, CA Bonagura, ...
Acta Crystallographica Section D: Structural Biology 72 (1), 2-11, 2016
752016
Crystal structure of the drug‐resistant S31N influenza M2 proton channel
JL Thomaston, WF DeGrado
Protein Science 25 (8), 1551-1554, 2016
452016
X-ray crystal structures of the influenza M2 proton channel drug-resistant V27A mutant bound to a spiro-adamantyl amine inhibitor reveal the mechanism of adamantane resistance
JL Thomaston, A Konstantinidi, L Liu, G Lambrinidis, J Tan, M Caffrey, ...
Biochemistry 59 (4), 627-634, 2020
322020
Detection of drug‐induced conformational change of a transmembrane protein in lipid bilayers using site‐directed spin labeling
JL Thomaston, PA Nguyen, EC Brown, MA Upshur, J Wang, WF DeGrado, ...
Protein Science 22 (1), 65-73, 2013
242013
X-ray crystal structure of the influenza A M2 proton channel S31N mutant in two conformational states: an open and shut case
JL Thomaston, Y Wu, N Polizzi, L Liu, J Wang, WF DeGrado
Journal of the American Chemical Society 141 (29), 11481-11488, 2019
232019
C‐terminal juxtamembrane region of full‐length M2 protein forms a membrane surface associated amphipathic helix
S Huang, B Green, M Thompson, R Chen, J Thomaston, WF DeGrado, ...
Protein Science 24 (3), 426-429, 2015
212015
Rimantadine binds to and inhibits the influenza A M2 proton channel without enantiomeric specificity
JL Thomaston, ML Samways, A Konstantinidi, C Ma, Y Hu, ...
Biochemistry 60 (32), 2471-2482, 2021
162021
Transient water wires mediate selective proton transport in designed channel proteins
HT Kratochvil, LC Watkins, M Mravic, JL Thomaston, JM Nicoludis, ...
Nature chemistry 15 (7), 1012-1021, 2023
72023
Transient water wires mediate selective proton conduction in designed channel proteins
HT Kratochvil, LC Watkins, M Mravic, JL Thomaston, L Liu, GA Voth, ...
bioRxiv, 2022
22022
XFEL structures of the influenza M2 proton channel at 1.4 Å: room temperature water networks and insights into proton conduction
JL Thomaston, RA Woldeyes, T Nakane, K Koiwai, A Yamashita, ...
Acta Crystallographica Section A: Foundations and Advances 73, a40-a40, 2017
12017
Correction for Thomaston et al., High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction.
JL Thomaston, M Alfonso-Prieto, RA Woldeyes, JS Fraser, ML Klein, ...
Proceedings of the National Academy of Sciences of the United States of …, 2016
12016
Structural basis of adamantane resistance in the influenza A M2 proton channel
J Thomaston, Y Wu, L Liu, J Wang, W DeGrado
Acta Crystallographica Section A: Foundations and Advances 75, e140-e140, 2019
2019
Structural characterization of adamantane-resistant mutants of the influenza M2 proton channel
JL Thomaston, WF DeGrado
Acta Crystallographica Section A: Foundations and Advances 74, a187-a187, 2018
2018
Proton Stabilization and Conduction Pathway in the Matrix Protein M2
HT Kratochvil, JL Thomaston, F Gai, WF DeGrado
Biophysical Journal 114 (3), 240a-241a, 2018
2018
Molecular Design and X-Ray Crystal Structure of Engineered Phospholamban Transmembrane Variant
M Mravic, J Thomaston, WF DeGrado
Biophysical Journal 114 (3), 36a, 2018
2018
X-Ray Crystal Structures of the Influenza a M2 Proton Channel Bound to Amantadine, Rimantadine, and Inhibiting Compounds
JL Thomaston, WF DeGrado
Biophysical Journal 114 (3), 204a, 2018
2018
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