| Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design A Friberg, D Vigil, B Zhao, RN Daniels, JP Burke, PM Garcia-Barrantes, ... Journal of medicinal chemistry 56 (1), 15-30, 2013 | 313 | 2013 |
| Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3 (2) B Zhao, X Lin, L Lei, DC Lamb, SL Kelly, MR Waterman, DE Cane Journal of Biological Chemistry 283 (13), 8183-8189, 2008 | 202 | 2008 |
| Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3 (2) cytochrome P450 158A2 B Zhao, FP Guengerich, A Bellamine, DC Lamb, M Izumikawa, L Lei, ... Journal of Biological Chemistry 280 (12), 11599-11607, 2005 | 175 | 2005 |
| Discovery of 2-indole-acylsulfonamide myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods NF Pelz, Z Bian, B Zhao, S Shaw, JC Tarr, J Belmar, C Gregg, ... Journal of medicinal chemistry 59 (5), 2054-2066, 2016 | 148 | 2016 |
| Electron transport pathway for a Streptomyces cytochrome P450: cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3 (2) YJ Chun, T Shimada, R Sanchez-Ponce, MV Martin, L Lei, B Zhao, ... Journal of Biological Chemistry 282 (24), 17486-17500, 2007 | 107 | 2007 |
| Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design JP Burke, Z Bian, S Shaw, B Zhao, CM Goodwin, J Belmar, CF Browning, ... Journal of medicinal chemistry 58 (9), 3794-3805, 2015 | 104 | 2015 |
| Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site B Zhao, L Lei, DG Vassylyev, X Lin, DE Cane, SL Kelly, H Yuan, DC Lamb, ... Journal of Biological Chemistry 284 (52), 36711-36719, 2009 | 97 | 2009 |
| Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer B Zhao, FP Guengerich, M Voehler, MR Waterman Journal of Biological Chemistry 280 (51), 42188-42197, 2005 | 96 | 2005 |
| Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants B Zhao, L Lei, N Kagawa, M Sundaramoorthy, S Banerjee, LD Nagy, ... Journal of Biological Chemistry 287 (13), 10613-10622, 2012 | 88 | 2012 |
| Displacement of WDR5 from chromatin by a WIN site inhibitor with picomolar affinity ER Aho, J Wang, RD Gogliotti, GC Howard, J Phan, P Acharya, ... Cell reports 26 (11), 2916-2928. e13, 2019 | 81 | 2019 |
| The cytochrome P450 gene family CYP157 does not contain EXXR in the K-helix reducing the absolute conserved P450 residues to a single cysteine S Rupasinghe, MA Schuler, N Kagawa, H Yuan, L Lei, B Zhao, SL Kelly, ... FEBS letters 580 (27), 6338-6342, 2006 | 70 | 2006 |
| Discovery and biological characterization of potent myeloid cell leukemia‐1 inhibitors T Lee, Z Bian, B Zhao, LJ Hogdal, JL Sensintaffar, CM Goodwin, J Belmar, ... FEBS letters 591 (1), 240-251, 2017 | 63 | 2017 |
| Discovery of WD repeat-containing protein 5 (WDR5)–MYC inhibitors using fragment-based methods and structure-based design S Chacón Simon, F Wang, LR Thomas, J Phan, B Zhao, ET Olejniczak, ... Journal of medicinal chemistry 63 (8), 4315-4333, 2020 | 59 | 2020 |
| Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes SC Moody, B Zhao, L Lei, DR Nelson, JGL Mullins, MR Waterman, ... The FEBS Journal 279 (9), 1640-1649, 2012 | 57 | 2012 |
| Different Binding Modes of Two Flaviolin Substrate Molecules in Cytochrome P450 158A1 (CYP158A1) Compared to CYP158A2, B Zhao, DC Lamb, L Lei, SL Kelly, H Yuan, DL Hachey, MR Waterman Biochemistry 46 (30), 8725-8733, 2007 | 57 | 2007 |
| Optimization of potent and selective tricyclic indole diazepinone myeloid cell leukemia-1 inhibitors using structure-based design S Shaw, Z Bian, B Zhao, JC Tarr, N Veerasamy, KO Jeon, J Belmar, ... Journal of medicinal chemistry 61 (6), 2410-2421, 2018 | 55 | 2018 |
| Three New Triterpenoids from Fuscoporia Obliqua J He, XZ Feng, Y Lu, B Zhao Journal of Asian Natural Products Research 3 (1), 55-61, 2001 | 53 | 2001 |
| Discovery of potent myeloid cell leukemia-1 (Mcl-1) inhibitors that demonstrate in vivo activity in mouse xenograft models of human cancer T Lee, PP Christov, S Shaw, JC Tarr, B Zhao, N Veerasamy, KO Jeon, ... Journal of medicinal chemistry 62 (8), 3971-3988, 2019 | 47 | 2019 |
| Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution JV Goldstone, M Sundaramoorthy, B Zhao, MR Waterman, JJ Stegeman, ... Molecular phylogenetics and evolution 94, 676-687, 2016 | 47 | 2016 |
| Fragment-based screening of programmed death ligand 1 (PD-L1) E Perry, JJ Mills, B Zhao, F Wang, Q Sun, PP Christov, JC Tarr, TA Rietz, ... Bioorganic & medicinal chemistry letters 29 (6), 786-790, 2019 | 45 | 2019 |
edward olejniczakprofessor biochemistry vanderbilt universityVerified email at vanderbilt.edu
