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Shikha kumari, PhD
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Amide bond bioisosteres: Strategies, synthesis, and successes
S Kumari, AV Carmona, AK Tiwari, PC Trippier
Journal of medicinal chemistry 63 (21), 12290-12358, 2020
3022020
Thiazole: A promising heterocycle for the development of potent CNS active agents
CB Mishra, S Kumari, M Tiwari
European journal of medicinal chemistry 92, 1-34, 2015
1852015
Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease
CB Mishra, S Kumari, A Manral, A Prakash, V Saini, AM Lynn, M Tiwari
European journal of medicinal chemistry 125, 736-750, 2017
1012017
Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and …
CB Mishra, A Manral, S Kumari, V Saini, M Tiwari
Bioorganic & medicinal chemistry 24 (16), 3829-3841, 2016
522016
Discovery of benzenesulfonamides with potent human carbonic anhydrase inhibitory and effective anticonvulsant action: design, synthesis, and pharmacological assessment
CB Mishra, S Kumari, A Angeli, SM Monti, M Buonanno, M Tiwari, ...
Journal of Medicinal Chemistry 60 (6), 2456-2469, 2017
502017
Synthesis, in vitro and in vivo anticancer activity of novel 1-(4-imino-1-substituted-1 H-pyrazolo [3, 4-d] pyrimidin-5 (4 H)-yl) urea derivatives
CB Mishra, RK Mongre, S Kumari, DK Jeong, M Tiwari
RSC advances 6 (29), 24491-24500, 2016
352016
Design and synthesis of a novel class of carbonic anhydrase-IX inhibitor 1-(3-(phenyl/4-fluorophenyl)-7-imino-3H-[1, 2, 3] triazolo [4, 5d] pyrimidin 6 (7H) yl) urea
S Kumari, D Idrees, CB Mishra, A Prakash, F Ahmad, MI Hassan, M Tiwari
Journal of Molecular Graphics and Modelling 64, 101-109, 2016
342016
Discovery of novel Methylsulfonyl phenyl derivatives as potent human Cyclooxygenase-2 inhibitors with effective anticonvulsant action: Design, synthesis, in-silico, in-vitro …
CB Mishra, S Kumari, A Prakash, R Yadav, AK Tiwari, P Pandey, M Tiwari
European journal of medicinal chemistry 151, 520-532, 2018
332018
Novel carbazole-piperazine hybrid small molecule induces apoptosis by targeting BCL-2 and inhibits tumor progression in lung adenocarcinoma in vitro and xenograft mice model
RK Mongre, CB Mishra, A Prakash, S Jung, BS Lee, S Kumari, JT Hong, ...
Cancers 11 (9), 1245, 2019
322019
Discovery of benzenesulfonamide derivatives as carbonic anhydrase inhibitors with effective anticonvulsant action: design, synthesis, and pharmacological evaluation
CB Mishra, S Kumari, A Angeli, S Bua, M Tiwari, CT Supuran
Journal of Medicinal Chemistry 61 (7), 3151-3165, 2018
302018
Novel Triazole-Piperazine Hybrid Molecules Induce Apoptosis via Activation of the Mitochondrial Pathway and Exhibit Antitumor Efficacy in Osteosarcoma …
CB Mishra, RK Mongre, S Kumari, DK Jeong, M Tiwari
ACS chemical biology 12 (3), 753-768, 2017
282017
Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents
S Kumari, CB Mishra, M Tiwari
Bioorganic & Medicinal Chemistry Letters 25 (5), 1092-1099, 2015
282015
Development of novel carbazole derivatives with effective multifunctional action against Alzheimer’s diseases: design, synthesis, in silico, in vitro and in vivo investigation
CB Mishra, S Gusain, S Shalini, S Kumari, A Prakash, N Kumari, ...
Bioorganic chemistry 95, 103524, 2020
232020
Design, synthesis and biological evaluation of N-(5-methyl-isoxazol-3-yl/1,3,4-thiadiazol-2-yl)-4-(3-substitutedphenylureido) benzenesulfonamides as human …
CB Mishra, S Kumari, A Angeli, SM Monti, M Buonanno, A Prakash, ...
Journal of Enzyme Inhibition and Medicinal Chemistry 31 (sup2), 174-179, 2016
232016
Discovery of potent anti-convulsant carbonic anhydrase inhibitors: design, synthesis, in vitro and in vivo appraisal
CB Mishra, S Kumari, A Angeli, S Bua, M Buonanno, SM Monti, M Tiwari, ...
European Journal of Medicinal Chemistry 156, 430-443, 2018
222018
Design and synthesis of some new 1-phenyl-3/4-[4-(aryl/heteroaryl/alkyl-piperazine1-yl)-phenyl-ureas as potent anticonvulsant and antidepressant agents
CB Mishra, S Kumari, M Tiwari
Archives of pharmacal research 39, 603-617, 2016
222016
Pharmacological evaluation of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea as potent anticonvulsant and antidepressant agent
S Kumari, CB Mishra, M Tiwari
Pharmacological Reports 68 (2), 250-258, 2016
222016
Discovery of potent carbonic anhydrase inhibitors as effective anticonvulsant agents: drug design, synthesis, and in vitro and in vivo investigations
CB Mishra, S Kumari, A Angeli, S Bua, RK Mongre, M Tiwari, CT Supuran
Journal of Medicinal Chemistry 64 (6), 3100-3114, 2021
192021
Pivotal role of nitrogen heterocycles in Alzheimer’s disease drug discovery
S Kumari, K Maddeboina, RD Bachu, SHS Boddu, PC Trippier, AK Tiwari
Drug Discovery Today 27 (10), 103322, 2022
182022
Polypharmacological drugs in the treatment of epilepsy: the comprehensive review of marketed and new emerging molecules
S Kumari, C Bhushan Mishra, M Tiwari
Current pharmaceutical design 22 (21), 3212-3225, 2016
172016
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