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Marcus Fischer
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Tripartite ATP-independent periplasmic (TRAP) transporters in bacteria and archaea
C Mulligan, M Fischer, GH Thomas
FEMS microbiology reviews 35 (1), 68-86, 2011
2102011
Conformation-independent structural comparison of macromolecules with ProSMART
RA Nicholls, M Fischer, S McNicholas, GN Murshudov
Acta Crystallographica Section D: Biological Crystallography 70 (9), 2487-2499, 2014
1622014
Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery
M Fischer, RG Coleman, JS Fraser, BK Shoichet
Nature chemistry 6 (7), 575-583, 2014
1422014
Water networks can determine the affinity of ligand binding to proteins
JF Darby, AP Hopkins, S Shimizu, SM Roberts, JA Brannigan, ...
Journal of the American Chemical Society 141 (40), 15818-15826, 2019
1032019
One crystal, two temperatures: Cryocooling penalties alter ligand binding to transient protein sites
M Fischer, BK Shoichet, JS Fraser
ChemBioChem 16 (11), 1560-1564, 2015
762015
Testing inhomogeneous solvation theory in structure-based ligand discovery
TE Balius, M Fischer, RM Stein, TB Adler, CN Nguyen, A Cruz, MK Gilson, ...
Proceedings of the National Academy of Sciences 114 (33), E6839-E6846, 2017
752017
Caught in a TRAP: substrate-binding proteins in secondary transport
M Fischer, QY Zhang, RE Hubbard, GH Thomas
Trends in microbiology 18 (10), 471-478, 2010
722010
Fragment-based ligand discovery
M Fischer, RE Hubbard
Molecular interventions 9 (1), 22, 2009
672009
Hydrogen bonding of 1, 2-azaborines in the binding cavity of T4 lysozyme mutants: Structures and thermodynamics
H Lee, M Fischer, BK Shoichet, SY Liu
Journal of the American Chemical Society 138 (37), 12021-12024, 2016
662016
Blind prediction of charged ligand binding affinities in a model binding site
GJ Rocklin, SE Boyce, M Fischer, I Fish, DL Mobley, BK Shoichet, KA Dill
Journal of molecular biology 425 (22), 4569-4583, 2013
612013
Comparative assessment of different histidine-tags for immobilization of protein onto surface plasmon resonance sensorchips
M Fischer, AP Leech, RE Hubbard
Analytical chemistry 83 (5), 1800-1807, 2011
572011
Macromolecular room temperature crystallography
M Fischer
Quarterly Reviews of Biophysics 54, e1, 2021
562021
Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs
J Min, A Mayasundari, F Keramatnia, B Jonchere, SW Yang, J Jarusiewicz, ...
Angewandte Chemie International Edition 60 (51), 26663-26670, 2021
542021
Identification of potent, selective, and orally bioavailable small-molecule GSPT1/2 degraders from a focused library of cereblon modulators
G Nishiguchi, F Keramatnia, J Min, Y Chang, B Jonchere, S Das, M Actis, ...
Journal of medicinal chemistry 64 (11), 7296-7311, 2021
542021
Diagnostic accuracy for major depression in multiple sclerosis using self‐report questionnaires
A Fischer, M Fischer, RA Nicholls, S Lau, J Poettgen, K Patas, C Heesen, ...
Brain and behavior 5 (9), e00365, 2015
502015
Homologous ligands accommodated by discrete conformations of a buried cavity
M Merski, M Fischer, TE Balius, O Eidam, BK Shoichet
Proceedings of the National Academy of Sciences 112 (16), 5039-5044, 2015
492015
Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia
Y Chang, J Min, JA Jarusiewicz, M Actis, S Yu-Chen Bradford, ...
Blood, The Journal of the American Society of Hematology 138 (23), 2313-2326, 2021
372021
Tripartite ATP-independent periplasmic (TRAP) transporters use an arginine-mediated selectivity filter for high affinity substrate binding
M Fischer, AP Hopkins, E Severi, J Hawkhead, D Bawdon, AG Watts, ...
Journal of Biological Chemistry 290 (45), 27113-27123, 2015
372015
Roles for ordered and bulk solvent in ligand recognition and docking in two related cavities
S Barelier, SE Boyce, I Fish, M Fischer, DB Goodin, BK Shoichet
PLoS One 8 (7), e69153, 2013
292013
Temperature artifacts in protein structures bias ligand-binding predictions
SYC Bradford, L El Khoury, Y Ge, M Osato, DL Mobley, M Fischer
Chemical Science 12 (34), 11275-11293, 2021
242021
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Articles 1–20