Manolis Roulis
Manolis Roulis
Associate Research Scientist, Yale School of Medicine
Verified email at
Cited by
Cited by
Pleiotropic functions of TNF-α in the regulation of the intestinal epithelial response to inflammation
M Leppkes, M Roulis, MF Neurath, G Kollias, C Becker
International immunology 26 (9), 509-515, 2014
Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology
M Roulis, M Armaka, M Manoloukos, M Apostolaki, G Kollias
Proceedings of the National Academy of Sciences 108 (13), 5396-5401, 2011
Fibroblasts and myofibroblasts of the intestinal lamina propria in physiology and disease
M Roulis, RA Flavell
Differentiation 92 (3), 116-131, 2016
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche
M Roulis, A Kaklamanos, M Schernthanner, P Bielecki, J Zhao, E Kaffe, ...
Nature 580 (7804), 524-529, 2020
Role of β7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease
M Apostolaki, M Manoloukos, M Roulis, MA Wurbel, W Müller, ...
Gastroenterology 134 (7), 2025-2035, 2008
Enteric nervous system-derived IL-18 orchestrates mucosal barrier immunity
A Jarret, R Jackson, C Duizer, ME Healy, J Zhao, JM Rone, P Bielecki, ...
Cell 180 (1), 50-63. e12, 2020
Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis
M Roulis, C Nikolaou, E Kotsaki, E Kaffe, N Karagianni, V Koliaraki, ...
Proceedings of the National Academy of Sciences 111 (43), E4658-E4667, 2014
Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis
V Koliaraki, M Roulis, G Kollias
The Journal of clinical investigation 122 (11), 4231-4242, 2012
Host and microbiota interactions are critical for development of murine Crohn’s-like ileitis
M Roulis, G Bongers, M Armaka, T Salviano, Z He, A Singh, U Seidler, ...
Mucosal immunology 9 (3), 787-797, 2016
MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche
N Wu, H Sun, X Zhao, Y Zhang, J Tan, Y Qi, Q Wang, M Ng, Z Liu, L He, ...
Nature 592 (7855), 606-610, 2021
Zero-preserving imputation of single-cell RNA-seq data
GC Linderman, J Zhao, M Roulis, P Bielecki, RA Flavell, B Nadler, ...
Nature communications 13 (1), 1-11, 2022
m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway
T Zhang, C Ding, H Chen, J Zhao, Z Chen, B Chen, K Mao, Y Hao, ...
Science advances 8 (12), eabl5723, 2022
Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression
A Kaklamanos, J Rozman, M Roulis, N Karagianni, M Armaka, M Wu, ...
Scientific reports 7 (1), 1-15, 2017
RNA m6A demethylase ALKBH5 regulates the development of γδ T cells
C Ding, H Xu, Z Yu, M Roulis, R Qu, J Zhou, J Oh, J Crawford, Y Gao, ...
Proceedings of the National Academy of Sciences 119 (33), e2203318119, 2022
Map3k2-regulated intestinal stromal cells (MRISC) Define a distinct sub-cryptic stem cell niche for damage induced Wnt agonist R-spondin1 production
N Wu, H Sun, X Zhao, L Chen, Y Qi, Y Han, X Liu, C Gao, Q Wang, L He, ...
bioRxiv, 723221, 2019
RNA m6A demethylase ALKBH5 regulates the development of γδ T cells
R Flavell, C Ding, Z Yu, H Xu, M Roulis, R Qu, J Zhou, A Jarret, R Jackson, ...
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