Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1–dependent mechanism that is up-regulated by interleukin-13 SL Highfill, PC Rodriguez, Q Zhou, CA Goetz, BH Koehn, R Veenstra, ... Blood, The Journal of the American Society of Hematology 116 (25), 5738-5747, 2010 | 508 | 2010 |
Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality A Saha, K Aoyama, PA Taylor, BH Koehn, RG Veenstra, ... Blood, The Journal of the American Society of Hematology 122 (17), 3062-3073, 2013 | 185 | 2013 |
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance MA ElTanbouly, Y Zhao, E Nowak, J Li, E Schaafsma, I Le Mercier, ... Science 367 (6475), eaay0524, 2020 | 181 | 2020 |
The IL-33/ST2 axis augments effector T-cell responses during acute GVHD DK Reichenbach, V Schwarze, BM Matta, V Tkachev, E Lieberknecht, ... Blood, The Journal of the American Society of Hematology 125 (20), 3183-3192, 2015 | 175 | 2015 |
Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation ML Ford, BH Koehn, ME Wagener, W Jiang, S Gangappa, TC Pearson, ... The Journal of experimental medicine 204 (2), 299-309, 2007 | 152 | 2007 |
GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells BH Koehn, P Apostolova, JM Haverkamp, JS Miller, V McCullar, J Tolar, ... Blood, The Journal of the American Society of Hematology 126 (13), 1621-1628, 2015 | 139 | 2015 |
Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD BM Matta, DK Reichenbach, X Zhang, L Mathews, BH Koehn, GK Dwyer, ... Blood, The Journal of the American Society of Hematology 128 (3), 427-439, 2016 | 115 | 2016 |
Activation of p53 in immature myeloid precursor cells controls differentiation into Ly6c+ CD103+ monocytic antigen-presenting cells in tumors MD Sharma, PC Rodriguez, BH Koehn, B Baban, Y Cui, G Guo, ... Immunity 48 (1), 91-106. e6, 2018 | 113 | 2018 |
NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation LS Kean, K Hamby, B Koehn, E Lee, S Coley, L Stempora, AB Adams, ... American journal of transplantation 6 (2), 292-304, 2006 | 92 | 2006 |
PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue BH Koehn, ML Ford, IR Ferrer, K Borom, S Gangappa, AD Kirk, CP Larsen The Journal of Immunology 181 (8), 5313-5322, 2008 | 66 | 2008 |
A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter MA McGargill, D Mayerova, HE Stefanski, B Koehn, EA Parke, ... The Journal of Immunology 169 (4), 2141-2147, 2002 | 61 | 2002 |
Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD BH Koehn, A Saha, C McDonald-Hyman, M Loschi, G Thangavelu, L Ma, ... Blood, The Journal of the American Society of Hematology 134 (19), 1670-1682, 2019 | 58 | 2019 |
CD40/CD154 blockade inhibits dendritic cell expression of inflammatory cytokines but not costimulatory molecules IR Ferrer, D Liu, DF Pinelli, BH Koehn, LL Stempora, ML Ford The Journal of Immunology 189 (9), 4387-4395, 2012 | 41 | 2012 |
The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease C McDonald-Hyman, JT Muller, M Loschi, G Thangavelu, A Saha, ... The Journal of clinical investigation 128 (10), 4604-4621, 2018 | 40 | 2018 |
Limiting the amount and duration of antigen exposure during priming increases memory T cell requirement for costimulation during recall TL Floyd, BH Koehn, WH Kitchens, JM Robertson, JA Cheeseman, ... The Journal of Immunology 186 (4), 2033-2041, 2011 | 38 | 2011 |
Role of myeloid-derived suppressor cells in allogeneic hematopoietic cell transplantation BH Koehn, BR Blazar Journal of Leukocyte Biology 102 (2), 335-341, 2017 | 32 | 2017 |
Patients, pathogens, and protective immunity: the relevance of virus-induced alloreactivity in transplantation B Koehn, S Gangappa, JD Miller, R Ahmed, CP Larsen The Journal of Immunology 176 (5), 2691-2696, 2006 | 31 | 2006 |
Bystander activation and anti-tumor effects of CD8+ T cells following Interleukin-2 based immunotherapy is independent of CD4+ T cell help AM Monjazeb, JK Tietze, SK Grossenbacher, HH Hsiao, AE Zamora, ... PloS one 9 (8), e102709, 2014 | 28 | 2014 |
Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections BH Koehn, MA Williams, K Borom, S Gangappa, TC Pearson, R Ahmed, ... The Journal of Immunology 179 (4), 2616-2626, 2007 | 17 | 2007 |
Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo TL Ramos, S Bolivar-Wagers, S Jin, G Thangavelu, F Simonetta, PY Lin, ... Blood 141 (11), 1337-1352, 2023 | 14 | 2023 |