Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease A Goate, MC Chartier-Harlin, M Mullan, J Brown, F Crawford, L Fidani, ... Nature 349 (6311), 704-706, 1991 | 6411 | 1991 |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ... Nature genetics 45 (12), 1452-1458, 2013 | 4602 | 2013 |
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 M Hutton, CL Lendon, P Rizzu, M Baker, S Froelich, H Houlden, ... Nature 393 (6686), 702-705, 1998 | 4336 | 1998 |
Clinical and biomarker changes in dominantly inherited Alzheimer's disease RJ Bateman, C Xiong, TLS Benzinger, AM Fagan, A Goate, NC Fox, ... New England Journal of Medicine 367 (9), 795-804, 2012 | 4257 | 2012 |
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease D Harold, R Abraham, P Hollingworth, R Sims, A Gerrish, ML Hamshere, ... Nature genetics 41 (10), 1088-1093, 2009 | 3412 | 2009 |
TREM2 variants in Alzheimer's disease R Guerreiro, A Wojtas, J Bras, M Carrasquillo, E Rogaeva, E Majounie, ... New England Journal of Medicine 368 (2), 117-127, 2013 | 3263 | 2013 |
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, JS Mumm, ... Nature 398 (6727), 518-522, 1999 | 2751 | 1999 |
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ... Nature genetics 51 (3), 414-430, 2019 | 2482 | 2019 |
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, ... Nature genetics 43 (5), 429-435, 2011 | 2255 | 2011 |
Genome-wide association study reveals genetic risk underlying Parkinson's disease J Simon-Sanchez, C Schulte, JM Bras, M Sharma, JR Gibbs, D Berg, ... Nature genetics 41 (12), 1308-1312, 2009 | 2244 | 2009 |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ... Nature genetics 43 (5), 436-441, 2011 | 2223 | 2011 |
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease MA Nalls, N Pankratz, CM Lill, CB Do, DG Hernandez, M Saad, ... Nature genetics 46 (9), 989-993, 2014 | 2064 | 2014 |
Alzheimer’s disease: the challenge of the second century DM Holtzman, JC Morris, AM Goate Science translational medicine 3 (77), 77sr1-77sr1, 2011 | 1791 | 2011 |
Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene MC Chartier-Harlin, F Crawford, H Houlden, A Warren, D Hughes, ... Nature 353 (6347), 844-846, 1991 | 1786 | 1991 |
Alzheimer’s disease risk genes and mechanisms of disease pathogenesis CM Karch, AM Goate Biological psychiatry 77 (1), 43-51, 2015 | 1505 | 2015 |
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance JM Castellano, J Kim, FR Stewart, H Jiang, RB DeMattos, BW Patterson, ... Science translational medicine 3 (89), 89ra57-89ra57, 2011 | 1460 | 2011 |
Analysis of shared heritability in common disorders of the brain Brainstorm Consortium, V Anttila, B Bulik-Sullivan, HK Finucane, ... Science 360 (6395), eaap8757, 2018 | 1458 | 2018 |
New insights into the genetic etiology of Alzheimer’s disease and related dementias C Bellenguez, F Küçükali, IE Jansen, L Kleineidam, S Moreno-Grau, ... Nature genetics 54 (4), 412-436, 2022 | 1359 | 2022 |
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17 M Hong, V Zhukareva, V Vogelsberg-Ragaglia, Z Wszolek, L Reed, ... Science 282 (5395), 1914-1917, 1998 | 1226 | 1998 |
APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging JC Morris, CM Roe, C Xiong, AM Fagan, AM Goate, DM Holtzman, ... Annals of neurology 67 (1), 122-131, 2010 | 1008 | 2010 |