Robert F. Siliciano
Robert F. Siliciano
Professor of Medicine, Johns Hopkins University School of Medicine
Verified email at
Cited by
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Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
D Finzi, M Hermankova, T Pierson, LM Carruth, C Buck, RE Chaisson, ...
Science 278 (5341), 1295-1300, 1997
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
D Finzi, J Blankson, JD Siliciano, JB Margolick, K Chadwick, T Pierson, ...
Nature medicine 5 (5), 512-517, 1999
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
TW Chun, L Carruth, D Finzi, X Shen, JA DiGiuseppe, H Taylor, ...
Nature 387 (6629), 183-188, 1997
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
JD Siliciano, J Kajdas, D Finzi, TC Quinn, K Chadwick, JB Margolick, ...
Nature medicine 9 (6), 727-728, 2003
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
YC Ho, L Shan, NN Hosmane, J Wang, SB Laskey, DIS Rosenbloom, ...
Cell 155 (3), 540-551, 2013
In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency
TW Chun, D Finzi, J Margolick, K Chadwick, D Schwartz, RF Siliciano
Nature medicine 1 (12), 1284-1290, 1995
The challenge of viral reservoirs in HIV-1 infection
JN Blankson, D Persaud, RF Siliciano
Annual review of medicine 53 (1), 557-593, 2002
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
L Shan, K Deng, NS Shroff, CM Durand, SA Rabi, HC Yang, H Zhang, ...
Immunity 36 (3), 491-501, 2012
HIV latency
RF Siliciano, WC Greene
Cold Spring Harbor perspectives in medicine 1 (1), a007096, 2011
Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy
T Pierson, J McArthur, RF Siliciano
Annual review of immunology 18 (1), 665-708, 2000
Defective proviruses rapidly accumulate during acute HIV-1 infection
KM Bruner, AJ Murray, RA Pollack, MG Soliman, SB Laskey, AA Capoferri, ...
Nature medicine 22 (9), 1043-1049, 2016
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
S Eriksson, EH Graf, V Dahl, MC Strain, SA Yukl, ES Lysenko, RJ Bosch, ...
PLoS pathogens 9 (2), e1003174, 2013
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
KM Bruner, Z Wang, FR Simonetti, AM Bender, KJ Kwon, S Sengupta, ...
Nature 566 (7742), 120-125, 2019
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
K Deng, M Pertea, A Rongvaux, L Wang, CM Durand, G Ghiaur, J Lai, ...
Nature 517 (7534), 381-385, 2015
Redefining the viral reservoirs that prevent HIV-1 eradication
E Eisele, RF Siliciano
Immunity 37 (3), 377-388, 2012
New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo
CK Bullen, GM Laird, CM Durand, JD Siliciano, RF Siliciano
Nature medicine 20 (4), 425-429, 2014
A soluble CD4 protein selectively inhibits HIV replication and syncytium formation
RE Hussey, NE Richardson, M Kowalski, NR Brown, HC Chang, ...
Nature 331 (6151), 78-81, 1988
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
JB Dinoso, SY Kim, AM Wiegand, SE Palmer, SJ Gange, L Cranmer, ...
Proceedings of the National Academy of Sciences 106 (23), 9403-9408, 2009
Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating …
JR Bailey, AR Sedaghat, T Kieffer, T Brennan, PK Lee, M Wind-Rotolo, ...
Journal of virology 80 (13), 6441-6457, 2006
HIV-1 integration landscape during latent and active infection
LB Cohn, IT Silva, TY Oliveira, RA Rosales, EH Parrish, GH Learn, ...
Cell 160 (3), 420-432, 2015
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