| 4-phenylpiperidines, their preparation and use K Petrukhin, C Cioffi, G Johnson, N Dobri, E Freeman, P Chen, M Conlon, ... US Patent 10,273,243, 2019 | 73 | 2019 |
| Generation of 3-pyridyl biaryl systems via palladium-catalyzed Suzuki cross-couplings of aryl halides with 3-pyridylboroxin CL Cioffi, WT Spencer, JJ Richards, RJ Herr The Journal of organic chemistry 69 (6), 2210-2212, 2004 | 73 | 2004 |
| Synthesis of 24. xi.-squalamine, an anti-infective steroidal polyamine AD Pechulis, FH Bellevue III, CL Cioffi, SG Trapp, JP Fojtik, AA McKitty, ... The Journal of Organic Chemistry 60 (16), 5121-5126, 1995 | 68 | 1995 |
| Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt … CL Cioffi, N Dobri, EE Freeman, MP Conlon, P Chen, DG Stafford, ... Journal of Medicinal Chemistry 57 (18), 7731-7757, 2014 | 52 | 2014 |
| 8-Aminocyclazocine analogues: Synthesis and structure–activity relationships MP Wentland, G Xu, CL Cioffi, Y Ye, W Duan, DJ Cohen, AM Colasurdo, ... Bioorganic & medicinal chemistry letters 10 (2), 183-187, 2000 | 51 | 2000 |
| Modulation of NMDA receptor function as a treatment for schizophrenia CL Cioffi Bioorganic & medicinal chemistry letters 23 (18), 5034-5044, 2013 | 47 | 2013 |
| Modulation of glycine-mediated spinal neurotransmission for the treatment of chronic pain CL Cioffi Journal of medicinal chemistry 61 (7), 2652-2679, 2017 | 45 | 2017 |
| Synthesis of 2-aminobenzoxazoles using tetramethyl orthocarbonate or 1, 1-dichlorodiphenoxymethane CL Cioffi, JJ Lansing, H Yüksel The Journal of Organic Chemistry 75 (22), 7942-7945, 2010 | 45 | 2010 |
| Syntheses and opioid receptor binding affinities of 8-amino-2, 6-methano-3-benzazocines MP Wentland, Y Ye, CL Cioffi, R Lou, Q Zhou, G Xu, W Duan, ... Journal of medicinal chemistry 46 (5), 838-849, 2003 | 45 | 2003 |
| Novel Qualitative Structure-Activity Relationships for the Antinociceptive Actions of H2 Antagonists, H3Antagonists and Derivatives LB Hough, JW Nalwalk, BY Li, R Leurs, W Menge, H Timmerman, ... Journal of Pharmacology and Experimental Therapeutics 283 (3), 1534-1543, 1997 | 37 | 1997 |
| A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle B Racz, A Varadi, J Kong, R Allikmets, PG Pearson, G Johnson, CL Cioffi, ... Journal of Biological Chemistry 293 (29), 11574-11588, 2018 | 35 | 2018 |
| Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and … CL Cioffi, B Racz, EE Freeman, MP Conlon, P Chen, DG Stafford, ... Journal of medicinal chemistry 58 (15), 5863-5888, 2015 | 32 | 2015 |
| Convenient palladium-catalyzed preparation of primary anilines using a fluorous benzophenone imine reagent CL Cioffi, ML Berlin, RJ Herr Synlett 2004 (05), 0841-0845, 2004 | 32 | 2004 |
| Discovery of 2-substituted benzoxazole carboxamides as 5-HT3 receptor antagonists Z Yang, DJ Fairfax, JH Maeng, L Masih, A Usyatinsky, C Hassler, ... Bioorganic & medicinal chemistry letters 20 (22), 6538-6541, 2010 | 28 | 2010 |
| Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis Z Ma, K King, M Alqahtani, M Worden, P Muthuraman, CL Cioffi, ... PloS one 14 (10), e0224094, 2019 | 25 | 2019 |
| Design, synthesis, and preclinical efficacy of novel nonretinoid antagonists of retinol-binding protein 4 in the mouse model of hepatic steatosis CL Cioffi, B Racz, A Varadi, EE Freeman, MP Conlon, P Chen, L Zhu, ... Journal of medicinal chemistry 62 (11), 5470-5500, 2019 | 23 | 2019 |
| Glycine transporter-1 inhibitors, methods of making them, and uses thereof CL Cioffi, MA Wolf, PR Guzzo, S Liu, K Sadalapure US Patent 9,045,445, 2015 | 22 | 2015 |
| A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration Y Shin, G Moiseyev, K Petrukhin, CL Cioffi, P Muthuraman, Y Takahashi, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1864 (7 …, 2018 | 21 | 2018 |
| Substituted 4-phenylpiperidines, their preparation and use K Petrukhin, C Cioffi, G Johnson, R Allikmets, E Freeman, P Chen, ... US Patent 9,434,727, 2016 | 20 | 2016 |
| Octahydrocyclopentapyrroles, their preparation and use K Petrukhin, C Cioffi, G Johnson, N Dobri, E Freeman, P Chen, M Conlon, ... US Patent 9,637,450, 2017 | 18 | 2017 |
