leeanne McGurk
leeanne McGurk
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Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
HJ Kim, AR Raphael, ES LaDow, L McGurk, RA Weber, JQ Trojanowski, ...
Nature genetics 46 (2), 152-160, 2014
Drosophila as an In Vivo Model for Human Neurodegenerative Disease
L McGurk, A Berson, NM Bonini
Genetics 201 (2), 377-402, 2015
Poly (ADP-ribose) prevents pathological phase separation of TDP-43 by promoting liquid Demixing and stress granule localization
L McGurk, E Gomes, L Guo, J Mojsilovic-Petrovic, V Tran, RG Kalb, ...
Molecular cell 71 (5), 703-717. e9, 2018
Editing independent effects of ADARs on the miRNA/siRNA pathways
BSE Heale, LP Keegan, L McGurk, G Michlewski, J Brindle, CM Stanton, ...
The EMBO journal 28 (20), 3145-3156, 2009
Nuclear poly (ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis
L McGurk, J Mojsilovic-Petrovic, VM Van Deerlin, J Shorter, RG Kalb, ...
Acta neuropathologica communications 6 (1), 1-15, 2018
Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
LP Keegan, L McGurk, JP Palavicini, J Brindle, S Paro, X Li, ...
Nucleic Acids Research 39 (16), 7249-7262, 2011
Three-dimensional imaging of Drosophila melanogaster
L McGurk, H Morrison, LP Keegan, J Sharpe, MA O'Connell
PLoS One 2 (9), e834, 2007
Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System
Y Hayashi, LK Ford, L Fioriti, L McGurk, M Zhang
Journal of Neuroscience 41 (5), 834-844, 2021
Adar RNA editing-dependent and-independent effects are required for brain and innate immune functions in Drosophila
P Deng, A Khan, D Jacobson, N Sambrani, L McGurk, X Li, A Jayasree, ...
Nature Communications 11 (1), 1-13, 2020
Poly-A Binding Protein-1 Localization to a Subset of TDP-43 Inclusions in Amyotrophic Lateral Sclerosis Occurs More Frequently in Patients Harboring an Expansion in C9orf72
L McGurk, VM Lee, JQ Trojanowksi, VM Van Deerlin, EB Lee, NM Bonini
Journal of Neuropathology & Experimental Neurology 73 (9), 837-845, 2014
Poly (ADP-ribose) engages the TDP-43 nuclear-localization sequence to regulate granulo-filamentous aggregation
L McGurk, E Gomes, L Guo, J Shorter, NM Bonini
Biochemistry 57 (51), 6923-6926, 2018
Poly (ADP-Ribosylation) in Age-Related Neurological Disease
L McGurk, OM Rifai, NM Bonini
Trends in Genetics 35 (8), 601-613, 2019
Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila
L McGurk, NM Bonini
Human molecular genetics 21 (1), 76-84, 2012
Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy
A Khan, S Paro, L McGurk, N Sambrani, MC Hogg, J Brindle, G Pennetta, ...
BMC Biology 18 (1), 1-16, 2020
TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and-2
L McGurk, OM Rifai, NM Bonini
Journal of cell science 133 (12), jcs245811, 2020
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology
L François-Moutal, DD Scott, AJ Ambrose, CJ Zerio, ...
Scientific Reports 12 (1), 1-14, 2022
Yeast Informs Alzheimer's Disease
L McGurk, NM Bonini
Science 334 (6060), 1212-1213, 2011
The temporal and spatial expression pattern of myosin Va, Vb and VI in the mouse ovary
L McGurk, G Tzolovsky, N Spears, M Bownes
Gene expression patterns 6 (8), 900-907, 2006
Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence
L McGurk, OM Rifai, O Shcherbakova, AE Perlegos, CN Byrns, ...
Human Molecular Genetics 30 (19), 1797-1810, 2021
Ecdysteroid action in insect reproduction
AS Raikhel, L McGurk, M Bownes
Academic Press, 2003
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