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Eva Hyde
Eva Hyde
School of Biosciences, University of Birmingham, UK
Verified email at bham.ac.uk
Title
Cited by
Cited by
Year
Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone: Reversed binding orientations in different redox states of the enzyme
PR Race, AL Lovering, RM Green, A Ossor, SA White, PF Searle, ...
Journal of Biological Chemistry 280 (14), 13256-13264, 2005
2392005
Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.
PF Searle, MJ Chen, L Hu, PR Race, AL Lovering, JI Grove, C Guise, ...
Clinical & Experimental Pharmacology & Physiology 31 (11), 2004
1422004
The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 Å, 1.8 Å and 2.4 Å resolution
AL Lovering, EI Hyde, PF Searle, SA White
Journal of molecular biology 309 (1), 203-213, 2001
1372001
Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy
L Hu, C Yu, Y Jiang, J Han, Z Li, P Browne, PR Race, RJ Knox, PF Searle, ...
Journal of medicinal chemistry 46 (23), 4818-4821, 2003
952003
Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954
PR Race, AL Lovering, SA White, JI Grove, PF Searle, CW Wrighton, ...
Journal of molecular biology 368 (2), 481-492, 2007
932007
Generation of Escherichia Coli Nitroreductase Mutants Conferring Improved Cell Sensitization to the Prodrug CB1954
JI Grove, AL Lovering, C Guise, PR Race, CJ Wrighton, SA White, EI Hyde, ...
Cancer research 63 (17), 5532-5537, 2003
922003
Proton nuclear magnetic resonance saturation transfer studies of coenzyme binding to Lactobacillus casei dihydrofolate reductase
EI Hyde, B Birdsall, GCK Roberts, J Feeney, ASV Burgen
Biochemistry 19 (16), 3738-3746, 1980
85*1980
A simple mechanism for co‐dependence on two activators at an Escherichia coli promoter
JT Wade, TA Belyaeva, EI Hyde, SJW Busby
The EMBO Journal, 2001
822001
E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954
SO Vass, D Jarrom, WR Wilson, EI Hyde, PF Searle
British journal of cancer 100 (12), 1903-1911, 2009
772009
Proton NMR studies of the glucocorticoid receptor DNA-binding domain: sequential assignments and identification of secondary structure elements
T Härd, E Kellenbach, R Boelens, K Dahlman, J Carlstedt-Duke, ...
Biochemistry 29 (38), 9015-9023, 1990
741990
Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin
MJ Sutcliffe, M Jaseja, EI Hyde, X Lu, JA Williams
Nature Structural Biology 1 (11), 802-807, 1994
701994
Three‐dimensional structure of the RGD‐containing snake toxin albolabrin in solution, based on 1H NMR spectroscopy and simulated annealing calculations
KJ SMITH, M JASEJA, X LU, JA WILLIAMS, EVAI HYDE, IANP TRAYER
International Journal of Peptide and Protein Research 48 (3), 220-228, 1996
601996
1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the …
KJ Smith, GS Baillie, EI Hyde, X Li, TM Houslay, A McCahill, AJ Dunlop, ...
Cellular signalling 19 (12), 2612-2624, 2007
572007
Transcription activation at the Escherichia coli melAB promoter: the role of MelR and the cyclic AMP receptor protein
TA Belyaeva, JT Wade, CL Webster, VJ Howard, MS Thomas, EI Hyde, ...
Molecular Microbiology 36 (1), 211-222, 2000
562000
Steady-State and Stopped-Flow Kinetic Studies of Three Escherichia coli NfsB Mutants with Enhanced Activity for the Prodrug CB1954
D Jarrom, M Jaberipour, CP Guise, S Daff, SA White, PF Searle, EI Hyde
Biochemistry 48 (32), 7665-7672, 2009
532009
Negative cooperativity between folinic acid and coenzyme in their binding to L. casei dihydrofolate reductase
B Birdsall, ASV Burgen, EI Hyde, GCK Roberts, J Feeney
Biochemistry 20 (25), 7186-7195, 1981
461981
Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations
M Jaberipour, SO Vass, CP Guise, JI Grove, RJ Knox, L Hu, EI Hyde, ...
Biochemical pharmacology 79 (2), 102-111, 2010
432010
Transcription activation at the Escherichia coli melAB promoter: interactions of MelR with its DNA target site and with domain 4 of the RNA polymerase σ subunit
DC Grainger, CL Webster, TA Belyaeva, EI Hyde, SJW Busby
Molecular microbiology 51 (5), 1297-1309, 2004
412004
1H and 31P NMR characterization of two conformations of the trimethoprim-NADP+-dihydrofolate reductase complex
A GRONENBORN, B BIRDSALL, EVA HYDE, G ROBERTS, J FEENEY, ...
Molecular Pharmacology 20 (1), 145-153, 1981
411981
DNA binding and DNA bending by the MelR transcription activator protein from Escherichia coli
SJ Bourgerie, CM Michán, SJW Busby, EI Hyde, MS Thomas
Nucleic acids research 25 (9), 1685-1693, 1997
391997
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