James Hardwick
James Hardwick
Verified email at pfizer.com
TitleCited byYear
Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
JS Hardwick, FG Kuruvilla, JK Tong, AF Shamji, SL Schreiber
Proceedings of the National Academy of Sciences 96 (26), 14866-14870, 1999
6001999
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
J O'Neil, J Grim, P Strack, S Rao, D Tibbitts, C Winter, J Hardwick, ...
Journal of Experimental Medicine 204 (8), 1813-1824, 2007
5882007
Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes
R Cristescu, J Lee, M Nebozhyn, KM Kim, JC Ting, SS Wong, J Liu, ...
Nature medicine 21 (5), 449, 2015
5842015
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
WK Sung, H Zheng, S Li, R Chen, X Liu, Y Li, NP Lee, WH Lee, ...
Nature genetics 44 (7), 765, 2012
5612012
Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12–rapamycinassociated protein
RT Peterson, BN Desai, JS Hardwick, SL Schreiber
Proceedings of the National Academy of Sciences 96 (8), 4438-4442, 1999
5231999
Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
G Garcia-Manero, H Yang, C Bueso-Ramos, A Ferrajoli, J Cortes, ...
Blood 111 (3), 1060-1066, 2008
4622008
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
Z Kan, H Zheng, X Liu, S Li, TD Barber, Z Gong, H Gao, K Hao, ...
Genome research 23 (9), 1422-1433, 2013
3672013
Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study
E Galanis, KA Jaeckle, MJ Maurer, JM Reid, MM Ames, JS Hardwick, ...
Journal of clinical oncology 27 (12), 2052, 2009
2892009
Aprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with a broad range of moderately emetogenic chemotherapies and tumor types: a randomized …
BL Rapoport, K Jordan, JA Boice, A Taylor, C Brown, JS Hardwick, ...
Supportive Care in Cancer 18 (4), 423-431, 2010
2542010
Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394
JS Hardwick, BM Sefton
Proceedings of the National Academy of Sciences 92 (10), 4527-4531, 1995
1901995
Single-dose fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with cisplatin therapy: randomized, double-blind study protocol—EASE
S Grunberg, D Chua, A Maru, J Dinis, S DeVandry, JA Boice, JS Hardwick, ...
Journal of Clinical Oncology 29 (11), 1495-1501, 2011
1822011
Development of vorinostat: current applications and future perspectives for cancer therapy
VM Richon, J Garcia-Vargas, JS Hardwick
Cancer letters 280 (2), 201-210, 2009
1512009
Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers
A Saadi, NB Shannon, P Lao-Sirieix, M O’Donovan, E Walker, ...
Proceedings of the National Academy of Sciences 107 (5), 2177-2182, 2010
1302010
Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells
SS Rao, J O'Neil, CD Liberator, JS Hardwick, X Dai, T Zhang, E Tyminski, ...
Cancer research 69 (7), 3060-3068, 2009
1212009
A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia
CJ Peters, JRE Rees, RH Hardwick, JS Hardwick, SL Vowler, CAJ Ong, ...
Gastroenterology 139 (6), 1995-2004. e15, 2010
1142010
A phase I pharmacokinetic and pharmacodynamic study of dalotuzumab (MK-0646), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in patients with advanced solid …
F Atzori, J Tabernero, A Cervantes, L Prudkin, J Andreu, ...
Clinical Cancer Research 17 (19), 6304-6312, 2011
1022011
Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing
SS Wong, KM Kim, JC Ting, K Yu, J Fu, S Liu, R Cristescu, M Nebozhyn, ...
Nature communications 5, 5477, 2014
912014
The activated form of the Lck tyrosine protein kinase in cells exposed to hydrogen peroxide is phosphorylated at both Tyr-394 and Tyr-505
JS Hardwick, BM Sefton
Journal of Biological Chemistry 272 (41), 25429-25432, 1997
871997
Down‐regulation of the Notch pathway mediated by a γ‐secretase inhibitor induces anti‐tumour effects in mouse models of T‐cell leukaemia
J Tammam, C Ware, C Efferson, J O'neil, S Rao, X Qu, J Gorenstein, ...
British journal of pharmacology 158 (5), 1183-1195, 2009
752009
Patterns of Metastatic Spread and Mechanisms of Resistance to Crizotinib in ROS1-Positive Non–Small-Cell Lung Cancer
JF Gainor, D Tseng, S Yoda, I Dagogo-Jack, L Friboulet, JJ Lin, ...
JCO precision oncology 1, 1-13, 2017
612017
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