|Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins|
JS Hardwick, FG Kuruvilla, JK Tong, AF Shamji, SL Schreiber
Proceedings of the National Academy of Sciences 96 (26), 14866-14870, 1999
|FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors|
J O'Neil, J Grim, P Strack, S Rao, D Tibbitts, C Winter, J Hardwick, ...
Journal of Experimental Medicine 204 (8), 1813-1824, 2007
|Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes|
R Cristescu, J Lee, M Nebozhyn, KM Kim, JC Ting, SS Wong, J Liu, ...
Nature medicine 21 (5), 449, 2015
|Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma|
WK Sung, H Zheng, S Li, R Chen, X Liu, Y Li, NP Lee, WH Lee, ...
Nature genetics 44 (7), 765, 2012
|Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12–rapamycinassociated protein|
RT Peterson, BN Desai, JS Hardwick, SL Schreiber
Proceedings of the National Academy of Sciences 96 (8), 4438-4442, 1999
|Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes|
G Garcia-Manero, H Yang, C Bueso-Ramos, A Ferrajoli, J Cortes, ...
Blood 111 (3), 1060-1066, 2008
|Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma|
Z Kan, H Zheng, X Liu, S Li, TD Barber, Z Gong, H Gao, K Hao, ...
Genome research 23 (9), 1422-1433, 2013
|Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study|
E Galanis, KA Jaeckle, MJ Maurer, JM Reid, MM Ames, JS Hardwick, ...
Journal of clinical oncology 27 (12), 2052, 2009
|Aprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with a broad range of moderately emetogenic chemotherapies and tumor types: a randomized …|
BL Rapoport, K Jordan, JA Boice, A Taylor, C Brown, JS Hardwick, ...
Supportive Care in Cancer 18 (4), 423-431, 2010
|Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394|
JS Hardwick, BM Sefton
Proceedings of the National Academy of Sciences 92 (10), 4527-4531, 1995
|Single-dose fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with cisplatin therapy: randomized, double-blind study protocol—EASE|
S Grunberg, D Chua, A Maru, J Dinis, S DeVandry, JA Boice, JS Hardwick, ...
Journal of Clinical Oncology 29 (11), 1495-1501, 2011
|Development of vorinostat: current applications and future perspectives for cancer therapy|
VM Richon, J Garcia-Vargas, JS Hardwick
Cancer letters 280 (2), 201-210, 2009
|Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers|
A Saadi, NB Shannon, P Lao-Sirieix, M O’Donovan, E Walker, ...
Proceedings of the National Academy of Sciences 107 (5), 2177-2182, 2010
|Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells|
SS Rao, J O'Neil, CD Liberator, JS Hardwick, X Dai, T Zhang, E Tyminski, ...
Cancer research 69 (7), 3060-3068, 2009
|A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia|
CJ Peters, JRE Rees, RH Hardwick, JS Hardwick, SL Vowler, CAJ Ong, ...
Gastroenterology 139 (6), 1995-2004. e15, 2010
|A phase I pharmacokinetic and pharmacodynamic study of dalotuzumab (MK-0646), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in patients with advanced solid …|
F Atzori, J Tabernero, A Cervantes, L Prudkin, J Andreu, ...
Clinical Cancer Research 17 (19), 6304-6312, 2011
|Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing|
SS Wong, KM Kim, JC Ting, K Yu, J Fu, S Liu, R Cristescu, M Nebozhyn, ...
Nature communications 5, 5477, 2014
|The activated form of the Lck tyrosine protein kinase in cells exposed to hydrogen peroxide is phosphorylated at both Tyr-394 and Tyr-505|
JS Hardwick, BM Sefton
Journal of Biological Chemistry 272 (41), 25429-25432, 1997
|Down‐regulation of the Notch pathway mediated by a γ‐secretase inhibitor induces anti‐tumour effects in mouse models of T‐cell leukaemia|
J Tammam, C Ware, C Efferson, J O'neil, S Rao, X Qu, J Gorenstein, ...
British journal of pharmacology 158 (5), 1183-1195, 2009
|Patterns of Metastatic Spread and Mechanisms of Resistance to Crizotinib in ROS1-Positive Non–Small-Cell Lung Cancer|
JF Gainor, D Tseng, S Yoda, I Dagogo-Jack, L Friboulet, JJ Lin, ...
JCO precision oncology 1, 1-13, 2017