Thomas Durek
Thomas Durek
Senior Research Officer
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Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase
A Rak, O Pylypenko, T Durek, A Watzke, S Kushnir, L Brunsveld, ...
Science 302 (5645), 646-650, 2003
Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme
T Durek, VY Torbeev, SBH Kent
Proceedings of the National Academy of Sciences 104 (12), 4846-4851, 2007
Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase
KS Harris, T Durek, Q Kaas, AG Poth, EK Gilding, BF Conlan, I Saska, ...
Nature communications 6 (1), 1-10, 2015
Structure of doubly prenylated Ypt1: GDI complex and the mechanism of GDI‐mediated Rab recycling
O Pylypenko, A Rak, T Durek, S Kushnir, BE Dursina, NH Thomae, ...
The EMBO journal 25 (1), 13-23, 2006
Disulfide-rich macrocyclic peptides as templates in drug design
SE Northfield, CK Wang, CI Schroeder, T Durek, MW Kan, JE Swedberg, ...
European journal of medicinal chemistry 77, 248-257, 2014
Preformed selenoesters enable rapid native chemical ligation at intractable sites
T Durek, PF Alewood
Angewandte Chemie International Edition 50 (50), 12042-12045, 2011
Fmoc-based synthesis of disulfide-rich cyclic peptides
O Cheneval, CI Schroeder, T Durek, P Walsh, YH Huang, S Liras, ...
The Journal of organic chemistry 79 (12), 5538-5544, 2014
Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1. 7-mediated pain
JR Deuis, JS Wingerd, Z Winter, T Durek, Z Dekan, SR Sousa, ...
Toxins 8 (3), 78, 2016
Protein semi-synthesis: new proteins for functional and structural studies
T Durek, CFW Becker
Biomolecular engineering 22 (5-6), 153-172, 2005
Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin‐2
CI Schroeder, LD Rash, X Vila‐Farrés, KJ Rosengren, M Mobli, GF King, ...
Angewandte Chemie International Edition 53 (4), 1017-1020, 2014
Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro
K Alexandrov, I Heinemann, T Durek, V Sidorovitch, RS Goody, ...
Journal of the American Chemical Society 124 (20), 5648-5649, 2002
Synthesis of fluorescently labeled mono-and diprenylated Rab7 GTPase
T Durek, K Alexandrov, RS Goody, A Hildebrand, I Heinemann, ...
Journal of the American Chemical Society 126 (50), 16368-16378, 2004
Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases
MA Jackson, EK Gilding, T Shafee, KS Harris, Q Kaas, S Poon, K Yap, ...
Nature communications 9 (1), 1-12, 2018
Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells
I Vetter, CA Mozar, T Durek, JS Wingerd, PF Alewood, MJ Christie, ...
Biochemical pharmacology 83 (11), 1562-1571, 2012
Total chemical synthesis, folding, and assay of a small protein on a water‐compatible solid support
ECB Johnson, T Durek, SBH Kent
Angewandte Chemie 118 (20), 3361-3365, 2006
Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1
T Durek, I Vetter, CIA Wang, L Motin, O Knapp, DJ Adams, RJ Lewis, ...
ACS chemical biology 8 (6), 1215-1222, 2013
Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization
AC Conibear, S Chaousis, T Durek, K Johan Rosengren, DJ Craik, ...
Peptide Science 106 (1), 89-100, 2016
Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3
JE Jensen, T Durek, PF Alewood, DJ Adams, GF King, LD Rash
Toxicon 54 (1), 56-61, 2009
Synthesis of functionalized Rab GTPases by a combination of solution‐or solid‐phase lipopeptide synthesis with expressed protein ligation
L Brunsveld, A Watzke, T Durek, K Alexandrov, RS Goody, H Waldmann
Chemistry–A European Journal 11 (9), 2756-2772, 2005
Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta
S Poon, KS Harris, MA Jackson, OC McCorkelle, EK Gilding, T Durek, ...
Journal of experimental botany 69 (3), 633-641, 2018
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