Jason Dyck
Jason Dyck
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Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
TR Koves, JR Ussher, RC Noland, D Slentz, M Mosedale, O Ilkayeva, ...
Cell metabolism 7 (1), 45-56, 2008
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
MD Fullerton, S Galic, K Marcinko, S Sikkema, T Pulinilkunnil, ZP Chen, ...
Nature medicine 19 (12), 1649-1654, 2013
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
J Nagendran, SL Archer, D Soliman, V Gurtu, R Moudgil, A Haromy, ...
Circulation 116 (3), 238-248, 2007
Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury
W Wang, CJ Schulze, WL Suarez-Pinzon, JRB Dyck, G Sawicki, R Schulz
Circulation 106 (12), 1543-1549, 2002
Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity
DPY Koonen, RL Jacobs, M Febbraio, ME Young, CLM Soltys, H Ong, ...
diabetes 56 (12), 2863-2871, 2007
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
MS McMurtry, S Bonnet, X Wu, JRB Dyck, A Haromy, K Hashimoto, ...
Circulation research 95 (8), 830-840, 2004
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice
R Dentin, F Benhamed, I Hainault, V Fauveau, F Foufelle, JRB Dyck, ...
Diabetes 55 (8), 2159-2170, 2006
Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart
S Kovacic, CLM Soltys, AJ Barr, I Shiojima, K Walsh, JRB Dyck
Journal of Biological Chemistry 278 (41), 39422-39427, 2003
Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis
JD Crane, R Palanivel, EP Mottillo, AL Bujak, H Wang, RJ Ford, A Collins, ...
Nature medicine 21 (2), 166-172, 2015
AMPK alterations in cardiac physiology and pathology: enemy or ally?
JRB Dyck, GD Lopaschuk
The Journal of physiology 574 (1), 95-112, 2006
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated …
ED Michelakis, MS McMurtry, XC Wu, JRB Dyck, R Moudgil, TA Hopkins, ...
Circulation 105 (2), 244-250, 2002
A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
M Xie, D Zhang, JRB Dyck, Y Li, H Zhang, M Morishima, DL Mann, ...
Proceedings of the National Academy of Sciences 103 (46), 17378-17383, 2006
Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target
SL Archer, G Marsboom, GH Kim, HJ Zhang, PT Toth, EC Svensson, ...
Circulation 121 (24), 2661-2671, 2010
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte
AYM Chan, CLM Soltys, ME Young, CG Proud, JRB Dyck
Journal of Biological Chemistry 279 (31), 32771-32779, 2004
Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression
MS Bray, CA Shaw, MWS Moore, RAP Garcia, MM Zanquetta, DJ Durgan, ...
American Journal of Physiology-Heart and Circulatory Physiology 294 (2 …, 2008
Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases
BNM Zordoky, IM Robertson, JRB Dyck
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852 (6 …, 2015
In Vivo Gene Transfer of the O2-Sensitive Potassium Channel Kv1.5 Reduces Pulmonary Hypertension and Restores Hypoxic Pulmonary Vasoconstriction in …
ZI Pozeg, ED Michelakis, MS McMurtry, B Thébaud, XC Wu, JRB Dyck, ...
Circulation 107 (15), 2037-2044, 2003
Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a …
GD Lopaschuk, R Barr, PD Thomas, JRB Dyck
Circulation research 93 (3), e33-e37, 2003
The emerging role of metabolomics in the diagnosis and prognosis of cardiovascular disease
JR Ussher, S Elmariah, RE Gerszten, JRB Dyck
Journal of the American College of Cardiology 68 (25), 2850-2870, 2016
A role for peroxisome proliferator-activated receptor α (PPARα) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation …
FM Campbell, R Kozak, A Wagner, JY Altarejos, JRB Dyck, DD Belke, ...
Journal of Biological Chemistry 277 (6), 4098-4103, 2002
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