Joshua A. Bittker
Joshua A. Bittker
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A next generation connectivity map: L1000 platform and the first 1,000,000 profiles
A Subramanian, R Narayan, SM Corsello, DD Peck, TE Natoli, X Lu, ...
Cell 171 (6), 1437-1452. e17, 2017
Genetic and transcriptional evolution alters cancer cell line drug response
U Ben-David, B Siranosian, G Ha, H Tang, Y Oren, K Hinohara, ...
Nature 560 (7718), 325-330, 2018
The Drug Repurposing Hub: a next-generation drug library and information resource
SM Corsello, JA Bittker, Z Liu, J Gould, P McCarren, JE Hirschman, ...
Nature medicine 23 (4), 405-408, 2017
An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules
A Basu, NE Bodycombe, JH Cheah, EV Price, K Liu, GI Schaefer, ...
Cell 154 (5), 1151-1161, 2013
Correlating chemical sensitivity and basal gene expression reveals mechanism of action
MG Rees, B Seashore-Ludlow, JH Cheah, DJ Adams, EV Price, S Gill, ...
Nature chemical biology 12 (2), 109-116, 2016
Harnessing connectivity in a large-scale small-molecule sensitivity dataset
B Seashore-Ludlow, MG Rees, JH Cheah, M Cokol, EV Price, ME Coletti, ...
Cancer discovery 5 (11), 1210-1223, 2015
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling
SM Corsello, RT Nagari, RD Spangler, J Rossen, M Kocak, JG Bryan, ...
Nature cancer 1 (2), 235-248, 2020
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
N Kato, E Comer, T Sakata-Kato, A Sharma, M Sharma, M Maetani, ...
Nature 538 (7625), 344-349, 2016
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling
MJ Wawer, K Li, SM Gustafsdottir, V Ljosa, NE Bodycombe, MA Marton, ...
Proceedings of the National Academy of Sciences 111 (30), 10911-10916, 2014
Development of small-molecule probes that selectively kill cells induced to express mutant RAS
M Weïwer, JA Bittker, TA Lewis, K Shimada, WS Yang, L MacPherson, ...
Bioorganic & medicinal chemistry letters 22 (4), 1822-1826, 2012
Selective chemical inhibition of PGC-1α gluconeogenic activity ameliorates type 2 diabetes
K Sharabi, H Lin, CDJ Tavares, JE Dominy, JP Camporez, RJ Perry, ...
Cell 169 (1), 148-160. e15, 2017
Advancing biological understanding and therapeutics discovery with small-molecule probes
SL Schreiber, JD Kotz, M Li, J Aubé, CP Austin, JC Reed, H Rosen, ...
Cell 161 (6), 1252-1265, 2015
Nucleic acid evolution and minimization by nonhomologous random recombination
JA Bittker, BV Le, DR Liu
Nature biotechnology 20 (10), 1024-1029, 2002
A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay
MA Bray, SM Gustafsdottir, MH Rohban, S Singh, V Ljosa, KL Sokolnicki, ...
Gigascience 6 (12), giw014, 2017
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells
KA Hartwell, PG Miller, S Mukherjee, AR Kahn, AL Stewart, DJ Logan, ...
Nature chemical biology 9 (12), 840-848, 2013
Evolving BioAssay Ontology (BAO): modularization, integration and applications
S Abeyruwan, UD Vempati, H Küçük-McGinty, U Visser, A Koleti, A Mir, ...
Journal of biomedical semantics 5, 1-22, 2014
Recent advances in the in vitro evolution of nucleic acids
JA Bittker, KJ Phillips, DR Liu
Current opinion in chemical biology 6 (3), 367-374, 2002
Small-molecule inducers of insulin expression in pancreatic α-cells
D Fomina-Yadlin, S Kubicek, D Walpita, V Dančik, J Hecksher-Sĝrensen, ...
Proceedings of the National Academy of Sciences 107 (34), 15099-15104, 2010
Directed evolution of protein enzymes using nonhomologous random recombination
JA Bittker, BV Le, JM Liu, DR Liu
Proceedings of the National Academy of Sciences 101 (18), 7011-7016, 2004
High-throughput screens to identify autophagy inducers that function by disrupting Beclin 1/Bcl-2 binding
WC Chiang, Y Wei, YC Kuo, S Wei, A Zhou, Z Zou, J Yehl, MJ Ranaghan, ...
ACS chemical biology 13 (8), 2247-2260, 2018
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