| A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding PF Lin, W Blair, T Wang, T Spicer, Q Guo, N Zhou, YF Gong, HGH Wang, ... Proceedings of the National Academy of Sciences 100 (19), 11013-11018, 2003 | 481 | 2003 |
| Discovery of 4-Benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): A Novel HIV-1 Attachment Inhibitor That … T Wang, Z Zhang, OB Wallace, M Deshpande, H Fang, Z Yang, ... Journal of medicinal chemistry 46 (20), 4236-4239, 2003 | 286 | 2003 |
| Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation L Plate, CB Cooley, JJ Chen, RJ Paxman, CM Gallagher, F Madoux, ... elife 5, e15550, 2016 | 209 | 2016 |
| In vitro resistance profile of the human immunodeficiency virus type 1 protease inhibitor BMS-232632 YF Gong, BS Robinson, RE Rose, C Deminie, TP Spicer, D Stock, ... Antimicrobial agents and chemotherapy 44 (9), 2319-2326, 2000 | 169 | 2000 |
| Advanced development of primary pancreatic organoid tumor models for high-throughput phenotypic drug screening S Hou, H Tiriac, BP Sridharan, L Scampavia, F Madoux, J Seldin, ... SLAS DISCOVERY: Advancing Life Sciences R&D 23 (6), 574-584, 2018 | 139 | 2018 |
| Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes A Adibekian, BR Martin, JW Chang, KL Hsu, K Tsuboi, DA Bachovchin, ... Journal of the American Chemical Society 134 (25), 10345-10348, 2012 | 137 | 2012 |
| Reverse transcription takes place within extracellular HIV-1 virions: potential biological significance HUI ZHANG, Y ZHANG, TP SPICER, LZ ABBOTT, M ABBOTT, BJ POIESZ AIDS research and human retroviruses 9 (12), 1287-1296, 1993 | 126 | 1993 |
| Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors DA Bachovchin, JT Mohr, AE Speers, C Wang, JM Berlin, TP Spicer, ... Proceedings of the National Academy of Sciences 108 (17), 6811-6816, 2011 | 123 | 2011 |
| Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents YE Karapetyan, GF Sferrazza, M Zhou, G Ottenberg, T Spicer, P Chase, ... Proceedings of the National Academy of Sciences 110 (17), 7044-7049, 2013 | 120 | 2013 |
| Ebselen, a small-molecule capsid inhibitor of HIV-1 replication S Thenin-Houssier, IMS De Vera, L Pedro-Rosa, A Brady, A Richard, ... Antimicrobial agents and chemotherapy 60 (4), 2195-2208, 2016 | 111 | 2016 |
| NH-1, 2, 3-triazole inhibitors of the VIM-2 metallo-β-lactamase T Weide, SA Saldanha, D Minond, TP Spicer, JR Fotsing, M Spaargaren, ... ACS medicinal chemistry letters 1 (4), 150-154, 2010 | 106 | 2010 |
| Genetic heterogeneity in human T-cell leukemia/lymphoma virus type II DK Dube, MP Sherman, NK Saksena, V Bryz-Gornia, J Mendelson, ... Journal of virology 67 (3), 1175-1184, 1993 | 106 | 1993 |
| Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming JMD Grandjean, A Madhavan, L Cech, BO Seguinot, RJ Paxman, E Smith, ... Nature chemical biology 16 (10), 1052-1061, 2020 | 103 | 2020 |
| Potent and Selective Inhibitors of Glutathione S-Transferase Omega 1 That Impair Cancer Drug Resistance K Tsuboi, DA Bachovchin, AE Speers, TP Spicer, V Fernandez-Vega, ... Journal of the American Chemical Society 133 (41), 16605-16616, 2011 | 98 | 2011 |
| Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening SP Brothers, SA Saldanha, TP Spicer, M Cameron, BA Mercer, P Chase, ... Molecular pharmacology 77 (1), 46-57, 2010 | 76 | 2010 |
| A 1536-well 3D viability assay to assess the cytotoxic effect of drugs on spheroids F Madoux, A Tanner, M Vessels, L Willetts, S Hou, L Scampavia, ... SLAS DISCOVERY: Advancing Life Sciences R&D 22 (5), 516-524, 2017 | 74 | 2017 |
| A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes CL Peatey, TP Spicer, PS Hodder, KR Trenholme, DL Gardiner Molecular and biochemical parasitology 180 (2), 127-131, 2011 | 74 | 2011 |
| Antiviral indoleoxoacetyl piperazine derivatives WS Blair, M Deshpande, H Fang, PF Lin, TP Spicer, OB Wallace, H Wang, ... US Patent 6,469,006, 2002 | 73 | 2002 |
| HIV type 1 isolate Z321, the strain used to make a therapeutic HIV type 1 immunogen, is intersubtype recombinant DJ CHOI, S DUBE, TP SPICER, HB SLADE, FC JENSEN, BJ POIESZ AIDS research and human retroviruses 13 (4), 357-361, 1997 | 69 | 1997 |
| Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker DJ Richard, R Lena, T Bannister, N Blake, WE Pierceall, NE Carlson, ... Bioorganic & medicinal chemistry 21 (21), 6642-6649, 2013 | 67 | 2013 |
