Total synthesis of bryostatin 1 GE Keck, YB Poudel, TJ Cummins, A Rudra, JA Covel Journal of the American Chemical Society 133 (4), 744-747, 2011 | 178 | 2011 |
A Pd (0)-mediated indole (macro) cyclization reaction SP Breazzano, YB Poudel, DL Boger Journal of the American Chemical Society 135 (4), 1600-1606, 2013 | 107 | 2013 |
Streamlined total synthesis of uncialamycin and its application to the synthesis of designed analogues for biological investigations KC Nicolaou, Y Wang, M Lu, D Mandal, MR Pattanayak, R Yu, AA Shah, ... Journal of the American Chemical Society 138 (26), 8235-8246, 2016 | 81 | 2016 |
Molecular modeling, total synthesis, and biological evaluations of C9‐deoxy bryostatin 1 GE Keck, YB Poudel, A Rudra, JC Stephens, N Kedei, NE Lewin, ... Angewandte Chemie International Edition 49 (27), 4580-4584, 2010 | 63 | 2010 |
Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters GE Keck, YB Poudel, DS Welch, MB Kraft, AP Truong, JC Stephens, ... Organic letters 11 (3), 593-596, 2009 | 58 | 2009 |
Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs K Lee, YB Poudel, CM Glinkerman, DL Boger Tetrahedron 71 (35), 5897–5905, 2015 | 43 | 2015 |
Synthetic studies toward bryostatin 1: preparation of a C1–C16 fragment by pyran annulation GE Keck, DS Welch, YB Poudel Tetrahedron letters 47 (47), 8267-8270, 2006 | 37 | 2006 |
Synthesis of a des-B-Ring Bryostatin Analogue Leads to an Unexpected Ring Expansion of the Bryolactone Core MB Kraft, YB Poudel, N Kedei, NE Lewin, ML Peach, PM Blumberg, ... Journal of the American Chemical Society 136 (38), 13202-13208, 2014 | 32 | 2014 |
Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity GE Keck, YB Poudel, A Rudra, JC Stephens, N Kedei, NE Lewin, ... Bioorganic & medicinal chemistry letters 22 (12), 4084-4088, 2012 | 29 | 2012 |
Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1 N Kedei, NE Lewin, T Geczy, J Selezneva, DC Braun, J Chen, ... ACS chemical biology 8 (4), 767-777, 2013 | 28 | 2013 |
Chemical modification of linkers provides stable linker–payloads for the generation of antibody–drug conjugates YB Poudel, NS Chowdari, H Cheng, CI Iwuagwu, HD King, S Kotapati, ... ACS Medicinal Chemistry Letters 11 (11), 2190-2194, 2020 | 23 | 2020 |
Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates YB Poudel, C Rao, S Kotapati, M Deshpande, L Thevanayagam, C Pan, ... Bioorganic & Medicinal Chemistry Letters 30 (1), 126782, 2020 | 23 | 2020 |
Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential … N Kedei, A Telek, AM Michalowski, MB Kraft, W Li, YB Poudel, A Rudra, ... Biochemical pharmacology 85 (3), 313-324, 2013 | 23 | 2013 |
Universal affinity capture liquid chromatography-mass spectrometry assay for evaluation of biotransformation of site-specific antibody drug conjugates in preclinical studies S Kotapati, D Passmore, S Yamazoe, RKK Sanku, Q Cong, YB Poudel, ... Analytical chemistry 92 (2), 2065-2073, 2019 | 18 | 2019 |
Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor L He, S Gangwar, YB Poudel, P Sivaprakasam US Patent 10,508,115, 2019 | 17 | 2019 |
Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor IS Young, S Gangwar, YB POUDEL, P SIVAPRAKASAM | 16 | 2021 |
Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor L He, S Gangwar, SL Posy, YB Poudel, P Sivaprakasam US Patent 10,487,084, 2019 | 16 | 2019 |
Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor YB Poudel, L He, S Gangwar, SL Posy, P Sivaprakasam US Patent 10,494,370, 2019 | 14 | 2019 |
Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor YB Poudel, S Gangwar, P Sivaprakasam, SL Posy US Patent 10,472,361, 2019 | 14 | 2019 |
1H-pyrazolo [4, 3-d] pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor YB Poudel, S Gangwar, L He, P Sivaprakasam, M Broekema, M Cox, ... US Patent 11,554,120, 2023 | 12 | 2023 |