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Yam Poudel
Yam Poudel
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Title
Cited by
Cited by
Year
Total synthesis of bryostatin 1
GE Keck, YB Poudel, TJ Cummins, A Rudra, JA Covel
Journal of the American Chemical Society 133 (4), 744-747, 2011
1782011
A Pd (0)-mediated indole (macro) cyclization reaction
SP Breazzano, YB Poudel, DL Boger
Journal of the American Chemical Society 135 (4), 1600-1606, 2013
1072013
Streamlined total synthesis of uncialamycin and its application to the synthesis of designed analogues for biological investigations
KC Nicolaou, Y Wang, M Lu, D Mandal, MR Pattanayak, R Yu, AA Shah, ...
Journal of the American Chemical Society 138 (26), 8235-8246, 2016
812016
Molecular modeling, total synthesis, and biological evaluations of C9‐deoxy bryostatin 1
GE Keck, YB Poudel, A Rudra, JC Stephens, N Kedei, NE Lewin, ...
Angewandte Chemie International Edition 49 (27), 4580-4584, 2010
632010
Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters
GE Keck, YB Poudel, DS Welch, MB Kraft, AP Truong, JC Stephens, ...
Organic letters 11 (3), 593-596, 2009
582009
Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs
K Lee, YB Poudel, CM Glinkerman, DL Boger
Tetrahedron 71 (35), 5897–5905, 2015
432015
Synthetic studies toward bryostatin 1: preparation of a C1–C16 fragment by pyran annulation
GE Keck, DS Welch, YB Poudel
Tetrahedron letters 47 (47), 8267-8270, 2006
372006
Synthesis of a des-B-Ring Bryostatin Analogue Leads to an Unexpected Ring Expansion of the Bryolactone Core
MB Kraft, YB Poudel, N Kedei, NE Lewin, ML Peach, PM Blumberg, ...
Journal of the American Chemical Society 136 (38), 13202-13208, 2014
322014
Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity
GE Keck, YB Poudel, A Rudra, JC Stephens, N Kedei, NE Lewin, ...
Bioorganic & medicinal chemistry letters 22 (12), 4084-4088, 2012
292012
Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1
N Kedei, NE Lewin, T Geczy, J Selezneva, DC Braun, J Chen, ...
ACS chemical biology 8 (4), 767-777, 2013
282013
Chemical modification of linkers provides stable linker–payloads for the generation of antibody–drug conjugates
YB Poudel, NS Chowdari, H Cheng, CI Iwuagwu, HD King, S Kotapati, ...
ACS Medicinal Chemistry Letters 11 (11), 2190-2194, 2020
232020
Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates
YB Poudel, C Rao, S Kotapati, M Deshpande, L Thevanayagam, C Pan, ...
Bioorganic & Medicinal Chemistry Letters 30 (1), 126782, 2020
232020
Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential …
N Kedei, A Telek, AM Michalowski, MB Kraft, W Li, YB Poudel, A Rudra, ...
Biochemical pharmacology 85 (3), 313-324, 2013
232013
Universal affinity capture liquid chromatography-mass spectrometry assay for evaluation of biotransformation of site-specific antibody drug conjugates in preclinical studies
S Kotapati, D Passmore, S Yamazoe, RKK Sanku, Q Cong, YB Poudel, ...
Analytical chemistry 92 (2), 2065-2073, 2019
182019
Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
L He, S Gangwar, YB Poudel, P Sivaprakasam
US Patent 10,508,115, 2019
172019
Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
IS Young, S Gangwar, YB POUDEL, P SIVAPRAKASAM
162021
Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
L He, S Gangwar, SL Posy, YB Poudel, P Sivaprakasam
US Patent 10,487,084, 2019
162019
Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
YB Poudel, L He, S Gangwar, SL Posy, P Sivaprakasam
US Patent 10,494,370, 2019
142019
Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor
YB Poudel, S Gangwar, P Sivaprakasam, SL Posy
US Patent 10,472,361, 2019
142019
1H-pyrazolo [4, 3-d] pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
YB Poudel, S Gangwar, L He, P Sivaprakasam, M Broekema, M Cox, ...
US Patent 11,554,120, 2023
122023
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