Melanie Königshoff
Melanie Königshoff
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WNT1-inducible signaling protein–1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
M Königshoff, M Kramer, N Balsara, J Wilhelm, OV Amarie, A Jahn, ...
The Journal of clinical investigation 119 (4), 772-787, 2009
Functional Wnt signaling is increased in idiopathic pulmonary fibrosis
M Königshoff, N Balsara, EM Pfaff, M Kramer, I Chrobak, W Seeger, ...
PloS one 3 (5), e2142, 2008
Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury
CJ Scotton, MA Krupiczojc, M Königshoff, PF Mercer, YCG Lee, ...
The Journal of clinical investigation 119 (9), 2550-2563, 2009
WNT signaling in lung disease: a failure or a regeneration signal?
M Königshoff, O Eickelberg
American journal of respiratory cell and molecular biology 42 (1), 21-31, 2010
Hallmarks of the ageing lung
S Meiners, O Eickelberg, M Königshoff
European Respiratory Journal 45 (3), 807-827, 2015
Shared and distinct mechanisms of fibrosis
JHW Distler, AH Györfi, M Ramanujam, ML Whitfield, M Königshoff, ...
Nature Reviews Rheumatology 15 (12), 705-730, 2019
Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
M Lehmann, M Korfei, K Mutze, S Klee, W Skronska-Wasek, HN Alsafadi, ...
European Respiratory Journal 50 (2), 2017
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
M Strunz, LM Simon, M Ansari, JJ Kathiriya, I Angelidis, CH Mayr, ...
Nature communications 11 (1), 3559, 2020
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
C Muus, MD Luecken, G Eraslan, L Sikkema, A Waghray, G Heimberg, ...
Nature medicine 27 (3), 546-559, 2021
An official American Thoracic Society workshop report: use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis
RG Jenkins, BB Moore, RC Chambers, O Eickelberg, M Königshoff, ...
American journal of respiratory cell and molecular biology 56 (5), 667-679, 2017
The WNT signaling pathway from ligand secretion to gene transcription: molecular mechanisms and pharmacological targets
HA Baarsma, M Königshoff, R Gosens
Pharmacology & therapeutics 138 (1), 66-83, 2013
Protease-Mediated Release of Chemotherapeutics from Mesoporous Silica Nanoparticles to ex Vivo Human and Mouse Lung Tumors
SH van Rijt, DA Bölükbas, C Argyo, S Datz, M Lindner, O Eickelberg, ...
ACS nano 9 (3), 2377-2389, 2015
Activation of the WNT/β-catenin pathway attenuates experimental emphysema
N Kneidinger, AO Yildirim, J Callegari, S Takenaka, MM Stein, ...
American journal of respiratory and critical care medicine 183 (6), 723-733, 2011
WNT/β-catenin signaling induces IL-1β expression by alveolar epithelial cells in pulmonary fibrosis
V Aumiller, N Balsara, J Wilhelm, A Günther, M Königshoff
American journal of respiratory cell and molecular biology 49 (1), 96-104, 2013
Transgelin is a direct target of TGF‐β/Smad3‐dependent epithelial cell migration in lung fibrosis
H Yu, M Königshoff, A Jayachandran, D Handley, W Seeger, N Kaminski, ...
The FASEB Journal 22 (6), 1778-1789, 2008
Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?
CA Brandsma, M de Vries, R Costa, RR Woldhuis, M Königshoff, ...
European Respiratory Review 26 (146), 2017
Loss of RAGE in pulmonary fibrosis: molecular relations to functional changes in pulmonary cell types
MA Queisser, FM Kouri, M Konigshoff, M Wygrecka, U Schubert, ...
American journal of respiratory cell and molecular biology 39 (3), 337-345, 2008
‘WNT-er is coming’: WNT signalling in chronic lung diseases
HA Baarsma, M Königshoff
Thorax 72 (8), 746-759, 2017
Pulmonary epithelium is a prominent source of proteinase-activated receptor-1–inducible CCL2 in pulmonary fibrosis
PF Mercer, RH Johns, CJ Scotton, MA Krupiczojc, M Königshoff, ...
American journal of respiratory and critical care medicine 179 (5), 414-425, 2009
Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD
HA Baarsma, W Skronska-Wasek, K Mutze, F Ciolek, DE Wagner, ...
Journal of Experimental Medicine 214 (1), 143-163, 2017
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