Mahadev Kalyankar Ph.D.
Mahadev Kalyankar Ph.D.
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The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H2O2 and Plays an Integral Role in Insulin Signal Transduction
K Mahadev, H Motoshima, X Wu, JM Ruddy, RS Arnold, G Cheng, ...
Molecular and cellular biology 24 (5), 1844-1854, 2004
Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes
X Wu, H Motoshima, K Mahadev, TJ Stalker, R Scalia, BJ Goldstein
Diabetes 52 (6), 1355-1363, 2003
Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade
K Mahadev, A Zilbering, L Zhu, BJ Goldstein
Journal of Biological Chemistry 276 (24), 21938-21942, 2001
Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL
H Motoshima, X Wu, K Mahadev, BJ Goldstein
Biochemical and biophysical research communications 315 (2), 264-271, 2004
Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets
BJ Goldstein, K Mahadev, X Wu
Diabetes 54 (2), 311-321, 2005
Adiponectin suppression of high-glucose–induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway
R Ouedraogo, X Wu, SQ Xu, L Fuchsel, H Motoshima, K Mahadev, ...
Diabetes 55 (6), 1840-1846, 2006
Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo
R Ouedraogo, Y Gong, B Berzins, X Wu, K Mahadev, K Hough, L Chan, ...
The Journal of clinical investigation 117 (6), 1718-1726, 2007
Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes
K Mahadev, X Wu, A Zilbering, L Zhu, JTR Lawrence, BJ Goldstein
Journal of Biological Chemistry 276 (52), 48662-48669, 2001
Role of insulin-induced reactive oxygen species in the insulin signaling pathway
BJ Goldstein, K Mahadev, X Wu, L Zhu, H Motoshima
Antioxidants & redox signaling 7 (7-8), 1021-1031, 2005
Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell–cell adhesions in endothelial cells
Y Nakamura, N Patrushev, H Inomata, D Mehta, N Urao, HW Kim, M Razvi, ...
Circulation research 102 (10), 1182-1191, 2008
Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice …
J Li, JJ Wang, Q Yu, K Chen, K Mahadev, SX Zhang
Diabetes 59 (6), 1528-1538, 2010
Reactive oxygen species production via NADPH oxidase mediates TGF-β-induced cytoskeletal alterations in endothelial cells
T Hu, SP RamachandraRao, S Siva, C Valancius, Y Zhu, K Mahadev, ...
American Journal of Physiology-Renal Physiology 289 (4), F816-F825, 2005
Important role of Nox4 type NADPH oxidase in angiogenic responses in human microvascular endothelial cells in vitro
SR Datla, H Peshavariya, GJ Dusting, K Mahadev, BJ Goldstein, F Jiang
Arteriosclerosis, thrombosis, and vascular biology 27 (11), 2319-2324, 2007
Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation
CC Mandal, S Ganapathy, Y Gorin, K Mahadev, K Block, HE Abboud, ...
Biochemical Journal 433 (2), 393-402, 2011
Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells
K Mahadev, X Wu, S Donnelly, R Ouedraogo, AD Eckhart, BJ Goldstein
Cardiovascular Research 78 (2), 376-384, 2008
Adiponectin suppresses IκB kinase activation induced by tumor necrosis factor-α or high glucose in endothelial cells: role of cAMP and AMP kinase signaling
X Wu, K Mahadev, L Fuchsel, R Ouedraogo, S Xu, BJ Goldstein
American Journal of Physiology-Endocrinology and Metabolism 293 (6), E1836-E1844, 2007
Suppression of the transformed phenotype of breast cancer by tropomyosin-1
K Mahadev, G Raval, S Bharadwaj, MC Willingham, EM Lange, ...
Experimental cell research 279 (1), 40-51, 2002
Adiponectin Protects Against Angiotensin II or Tumor Necrosis Factor α–Induced Endothelial Cell Monolayer Hyperpermeability: Role of cAMP/PKA Signaling
SQ Xu, K Mahadev, X Wu, L Fuchsel, S Donnelly, RG Scalia, BJ Goldstein
Arteriosclerosis, Thrombosis, and Vascular Biology 28 (5), 899-905, 2008
Hyperglycemia Potentiates H2O2 Production in Adipocytes and Enhances Insulin Signal Transduction: Potential Role for Oxidative Inhibition of Thiol-Sensitive …
X Wu, LI Zhu, A Zilbering, K Mahadev, H Motoshima, J Yao, BJ Goldstein
Antioxidants & Redox Signaling 7 (5-6), 526-537, 2005
Integration of multiple downstream signals determines the net effect of insulin on MAP kinase vs. PI 3′-kinase activation: potential role of insulin-stimulated H2O2
K Mahadev, X Wu, H Motoshima, BJ Goldstein
Cellular signalling 16 (3), 323-331, 2004
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