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Edwin A. Saada
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Independent analysis of the flagellum surface and matrix proteomes provides insight into flagellum signaling in mammalian-infectious Trypanosoma brucei
M Oberholzer, G Langousis, HKT Nguyen, EA Saada, MM Shimogawa, ...
Molecular & Cellular Proteomics 10 (10), 2011
1492011
Insect stage-specific receptor adenylate cyclases are localized to distinct subdomains of the Trypanosoma brucei flagellar membrane
EA Saada, ZP Kabututu, M Lopez, MM Shimogawa, G Langousis, ...
Eukaryotic Cell 13 (8), 1064-1076, 2014
812014
Insect stage-specific adenylate cyclases regulate social motility in African trypanosomes
MA Lopez, EA Saada, KL Hill
Eukaryotic Cell 14 (1), 104-112, 2015
712015
Engineering of monosized lipid-coated mesoporous silica nanoparticles for CRISPR delivery
A Noureddine, A Maestas-Olguin, EA Saada, AE LaBauve, JO Agola, ...
Acta Biomaterialia 114, 358-368, 2020
682020
Cell surface proteomics provides insight into stage-specific remodeling of the host-parasite interface in Trypanosoma brucei
MM Shimogawa, EA Saada, AA Vashisht, WD Barshop, JA Wohlschlegel, ...
Molecular & cellular proteomics 14 (7), 1977-1988, 2015
652015
eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei
ER Freire, AA Vashisht, AM Malvezzi, J Zuberek, G Langousis, EA Saada, ...
RNA 20 (8), 1272-1286, 2014
632014
Trypanosoma brucei Translation Initiation Factor Homolog EIF4E6 Forms a Tripartite Cytosolic Complex with EIF4G5 and a Capping Enzyme Homolog
ER Freire, AM Malvezzi, AA Vashisht, J Zuberek, EA Saada, G Langousis, ...
Eukaryotic Cell 13 (7), 896-908, 2014
572014
Cyclic AMP regulates social behavior in African trypanosomes
M Oberholzer, EA Saada, KL Hill
MBio 6 (3), 10.1128/mbio. 01954-14, 2015
492015
Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei
G Langousis, MM Shimogawa, EA Saada, AA Vashisht, R Spreafico, ...
Proceedings of the National Academy of Sciences 113 (3), 632-637, 2016
402016
Use of anti-CRISPR protein AcrIIA4 as a capture ligand for CRISPR/Cas9 detection
RK Johnston, KJ Seamon, EA Saada, JD Podlevsky, SS Branda, ...
Biosensors and Bioelectronics 141, 111361, 2019
312019
Versatile high-throughput fluorescence assay for monitoring Cas9 activity
KJ Seamon, YK Light, EA Saada, JS Schoeniger, B Harmon
Analytical chemistry 90 (11), 6913-6921, 2018
272018
Discovery of small-molecule inhibitors of SARS-CoV-2 proteins using a computational and experimental pipeline
EY Lau, OA Negrete, WFD Bennett, BJ Bennion, M Borucki, F Bourguet, ...
Frontiers in Molecular Biosciences 8, 678701, 2021
222021
Timescale separation of positive and negative signaling creates history-dependent responses to IgE receptor stimulation
B Harmon, LA Chylek, Y Liu, ED Mitra, A Mahajan, EA Saada, ...
Scientific reports 7 (1), 15586, 2017
182017
"With a Little Help from My Friends"—Social Motility in Trypanosoma brucei
EA Saada, SF DeMarco, MM Shimogawa, KL Hill
PLOS Pathog 11 (12), e1005272, 2015
182015
Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies
MA Stefan, YK Light, JL Schwedler, PR McIlroy, CM Courtney, EA Saada, ...
MAbs 13 (1), 1958663, 2021
152021
Identification of positive chemotaxis in the protozoan pathogen Trypanosoma brucei
SF DeMarco, EA Saada, MA Lopez, KL Hill
Msphere 5 (4), 10.1128/msphere. 00685-20, 2020
132020
High-throughput virtual screening of small molecule inhibitors for SARS-CoV-2 protein targets with deep fusion models
GA Stevenson, D Jones, H Kim, WFD Bennett, BJ Bennion, M Borucki, ...
Proceedings of the International Conference for High Performance Computing …, 2021
122021
Cyclic AMP regulates social behavior in African trypanosomes. mBio 6: e01954-14
M Oberholzer, EA Saada, KL Hill, S Hajduk, TE Wellems
112015
Lipid-coated mesoporous silica nanoparticles for anti-viral applications via delivery of CRISPR-Cas9 ribonucleoproteins
AE LaBauve, EA Saada, IKA Jones, R Mosesso, A Noureddine, J Techel, ...
Scientific reports 13 (1), 6873, 2023
62023
Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants
TA Desautels, KT Arrildt, AT Zemla, EY Lau, F Zhu, D Ricci, S Cronin, ...
bioRxiv, 2022
22022
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