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Simon James Hedley
Simon James Hedley
Head of Process Research and Development, Quotient Sciences
Verified email at quotientsciences.com
Title
Cited by
Cited by
Year
Intermolecular reactions of electron-rich heterocycles with copper and rhodium carbenoids
HML Davies, SJ Hedley
Chemical Society Reviews 36 (7), 1109-1119, 2007
2802007
Investigation into Factors Influencing Stereoselectivity in the Reactions of Heterocycles with Donor− Acceptor-Substituted Rhodium Carbenoids
SJ Hedley, DL Ventura, PM Dominiak, CL Nygren, HML Davies
The Journal of Organic Chemistry 71 (14), 5349-5356, 2006
1022006
Development of a [3+ 3] cycloaddition strategy toward functionalized piperidines
SJ Hedley, WJ Moran, DA Price, JPA Harrity
The Journal of Organic Chemistry 68 (11), 4286-4292, 2003
91*2003
Asymmetric Intermolecular C− H Functionalization of Benzyl Silyl Ethers Mediated by Chiral Auxiliary-Based Aryldiazoacetates and Chiral Dirhodium Catalysts
HML Davies, SJ Hedley, BR Bohall
The Journal of Organic Chemistry 70 (26), 10737-10742, 2005
602005
Metal-free blue-light-mediated cyclopropanation of indoles by aryl (diazo) acetates
X Zhang, C Du, H Zhang, XC Li, YL Wang, JL Niu, MP Song
Synthesis 51 (04), 889-898, 2019
482019
Synthesis of functionalised piperidines through a [3+ 3] cycloaddition strategy
SJ Hedley, WJ Moran, AHGP Prenzel, DA Price, JPA Harrity
Synlett 2001 (10), 1596-1598, 2001
472001
Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors
RP Wurz, LH Pettus, K Ashton, J Brown, JJ Chen, B Herberich, FT Hong, ...
ACS Medicinal Chemistry Letters 6 (9), 987-992, 2015
302015
Formal synthesis of (±)-perhydrohistrionicotoxin via a stepwise [3+ 3] annelation strategy
OY Provoost, SJ Hedley, AJ Hazelwood, JPA Harrity
Tetrahedron letters 47 (3), 331-333, 2006
272006
Development of a practical synthesis of a pyrazolopyridinone-based p38 MAP kinase inhibitor
RR Milburn, OR Thiel, M Achmatowicz, X Wang, J Zigterman, C Bernard, ...
Organic Process Research & Development 15 (1), 31-43, 2011
232011
Vinyl Sulfoxonium Ylide: A New Vinyl Carbenoid Transfer Reagent for the Synthesis of Heterocycles
J Vaitla, A Bayer, KH Hopmann
Synlett 30 (12), 1377-1383, 2019
172019
Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor
L Zhang, DJ Griffin, MG Beaver, LE Blue, CJ Borths, DB Brown, S Caille, ...
Organic Process Research & Development 26 (11), 3115-3125, 2022
152022
Xantphos as a Branch-Selective Ligand for the Acyclic sec-Alkyl Negishi Cross-Coupling of Heteroaryl Halides
AH Cherney, SJ Hedley, SM Mennen, JS Tedrow
Organometallics 38 (1), 97-102, 2018
152018
Triazole agonists of the APJ receptor
N Chen, X Chen, Y Chen, AC Cheng, RV Connors, J Deignan, ...
US Patent 9,868,721, 2018
142018
Triazole agonists of the APJ receptor
N Chen, X Chen, Y Chen, AC Cheng, RV Connors, J Deignan, ...
US Patent 9,573,936, 2017
142017
Untitled
N Chen, X Chen, Y Chen, AC Cheng, RV Connors, J Deignan, ...
WO Patent 2016187308:A1, 2016
14*2016
Heterocyclic triazole compounds as agonists of the APJ receptor
X Chen, Y Chen, AC Cheng, RV Connors, MV DeBenedetto, ...
US Patent 9,988,369, 2018
132018
Intermediates for preparing triazole agonists of the APJ receptor
N Chen, X Chen, AC Cheng, RV Connors, J Deignan, PJ Dransfield, X Du, ...
US Patent 9,845,310, 2017
132017
Methods for preparing triazole agonists of the APJ receptor
N Chen, X Chen, RV Connors, J Deignan, PJ Dransfield, X Du, Z Fu, ...
US Patent 9,751,864, 2017
132017
Triazole agonists of the APJ receptor
N Chen, X Chen, Y Chen, AC Cheng, RV Connors, J Deignan, ...
US Patent 9,745,286, 2017
132017
Triazole agonists of the APJ receptor
N Chen, X Chen, AC Cheng, RV Connors, J Deignan, PJ Dransfield, X Du, ...
US Patent 9,656,997, 2017
132017
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