Arun K. Shukla
Arun K. Shukla
EMBO Young Investigator and Senior Fellow of India Alliance
Verified email at - Homepage
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Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors
E Reiter, S Ahn, AK Shukla, RJ Lefkowitz
Annual review of pharmacology and toxicology 52, 179-197, 2012
Distinct phosphorylation sites on the β2-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin
KN Nobles, K Xiao, S Ahn, AK Shukla, CM Lam, S Rajagopal, ...
Science signaling 4 (185), ra51-ra51, 2011
GPCR-G protein-β-arrestin super-complex mediates sustained G protein signaling
ARB Thomsen, B Plouffe, TJ Cahill, AK Shukla, JT Tarrasch, AM Dosey, ...
Cell 166 (4), 907-919, 2016
Visualization of arrestin recruitment by a G-protein-coupled receptor
AK Shukla, GH Westfield, K Xiao, RI Reis, LY Huang, P Tripathi-Shukla, ...
Nature 512 (7513), 218-222, 2014
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
AK Shukla, K Xiao, RJ Lefkowitz
Trends in biochemical sciences 36 (9), 457-469, 2011
Functional specialization of β-arrestin interactions revealed by proteomic analysis
K Xiao, DB McClatchy, AK Shukla, Y Zhao, M Chen, SK Shenoy, ...
Proceedings of the National Academy of Sciences 104 (29), 12011-12016, 2007
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide
AK Shukla, A Manglik, AC Kruse, K Xiao, RI Reis, WC Tseng, DP Staus, ...
Nature 497 (7447), 137-141, 2013
Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
TJ Cahill III, ARB Thomsen, JT Tarrasch, B Plouffe, AH Nguyen, F Yang, ...
Proceedings of the National Academy of Sciences 114 (10), 2562-2567, 2017
Multiple ligand-specific conformations of the β2-adrenergic receptor
AW Kahsai, K Xiao, S Rajagopal, S Ahn, AK Shukla, J Sun, TG Oas, ...
Nature chemical biology 7 (10), 692-700, 2011
Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors
AK Shukla, JD Violin, EJ Whalen, D Gesty-Palmer, SK Shenoy, ...
Proceedings of the National Academy of Sciences 105 (29), 9988-9993, 2008
β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice
RW Walters, AK Shukla, JJ Kovacs, JD Violin, SM DeWire, CM Lam, ...
The Journal of clinical investigation 119 (5), 1312-1321, 2009
Methodological advances: the unsung heroes of the GPCR structural revolution
E Ghosh, P Kumari, D Jaiman, AK Shukla
Nature Reviews Molecular Cell Biology 16 (2), 69-81, 2015
Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)
K Xiao, J Sun, J Kim, S Rajagopal, B Zhai, J Villén, W Haas, JJ Kovacs, ...
Proceedings of the National Academy of Sciences 107 (34), 15299-15304, 2010
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
SK Shenoy, AS Modi, AK Shukla, K Xiao, M Berthouze, S Ahn, ...
Proceedings of the National Academy of Sciences 106 (16), 6650-6655, 2009
β-Arrestin–dependent activation of Ca2+/calmodulin kinase II after β1–adrenergic receptor stimulation
S Mangmool, AK Shukla, HA Rockman
Journal of Cell Biology 189 (3), 573-587, 2010
Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor
Y Lee, T Warne, R Nehmé, S Pandey, H Dwivedi-Agnihotri, M Chaturvedi, ...
Nature 583 (7818), 862-866, 2020
Functional competence of a partially engaged GPCR–β-arrestin complex
P Kumari, A Srivastava, R Banerjee, E Ghosh, P Gupta, R Ranjan, X Chen, ...
Nature communications 7 (1), 13416, 2016
Ubiquitination of β-arrestin links seven-transmembrane receptor endocytosis and ERK activation
SK Shenoy, LS Barak, K Xiao, S Ahn, M Berthouze, AK Shukla, LM Luttrell, ...
Journal of Biological Chemistry 282 (40), 29549-29562, 2007
Emerging functional divergence of β-arrestin isoforms in GPCR function
A Srivastava, B Gupta, C Gupta, AK Shukla
Trends in Endocrinology & Metabolism 26 (11), 628-642, 2015
Emerging structural insights into biased GPCR signaling
AK Shukla, G Singh, E Ghosh
Trends in biochemical sciences 39 (12), 594-602, 2014
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